Institution
AkzoNobel
Company•Amsterdam, Netherlands•
About: AkzoNobel is a company organization based out in Amsterdam, Netherlands. It is known for research contribution in the topics: Alkyl & Coating. The organization has 6377 authors who have published 6017 publications receiving 110560 citations. The organization is also known as: AkzoNobel (Netherlands) & Akzo Nobel N.V..
Topics: Alkyl, Coating, Catalysis, Aqueous solution, Polymer
Papers published on a yearly basis
Papers
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TL;DR: The APC gene was identified in a contig initiated from the MCC gene and was found to encode an unusually large protein, and these two closely spaced genes encode proteins predicted to contain coiled-coil regions, which were also expressed in a wide variety of tissues.
Abstract: Recent studies suggest that one or more genes on chromosome 5q21 are important for the development of colorectal cancers, particularly those associated with familial adenomatous polyposis (FAP). To facilitate the identification of genes from this locus, a portion of the region that is tightly linked to FAP was cloned. Six contiguous stretches of sequence (contigs) containing approximately 5.5 Mb of DNA were isolated. Subclones from these contigs were used to identify and position six genes, all of which were expressed in normal colonic mucosa. Two of these genes (APC and MCC) are likely to contribute to colorectal tumorigenesis. The MCC gene had previously been identified by virtue of its mutation in human colorectal tumors. The APC gene was identified in a contig initiated from the MCC gene and was found to encode an unusually large protein. These two closely spaced genes encode proteins predicted to contain coiled-coil regions. Both genes were also expressed in a wide variety of tissues. Further studies of MCC and APC and their potential interaction should prove useful for understanding colorectal neoplasia.
2,364 citations
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TL;DR: The data suggest that more than one gene on chromosome 5q21 may contribute to colorectal neoplasia, and that mutations of the APC gene can cause both FAP and GS.
Abstract: Previous studies suggested that one or more genes on chromosome 5q21 are responsible for the inheritance of familial adenomatous polyposis (FAP) and Gardner's syndrome (GS), and contribute to tumor development in patients with noninherited forms of colorectal cancer. Two genes on 5q21 that are tightly linked to FAP (MCC and APC) were found to be somatically altered in tumors from sporadic colorectal cancer patients. One of the genes (APC) was also found to be altered by point mutation in the germ line of FAP and GS patients. These data suggest that more than one gene on chromosome 5q21 may contribute to colorectal neoplasia, and that mutations of the APC gene can cause both FAP and GS. The identification of these genes should aid in understanding the pathogenesis of colorectal neoplasia and in the diagnosis and counseling of patients with inherited predispositions to colorectal cancer.
1,882 citations
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15 Mar 2008
TL;DR: In this paper, a general definition and terminology for the Determination of Isotherm Isotherms is defined and a methodology for the determination of the isotherm is presented.
Abstract: The sections in this article are
Introduction
General Definitions and Terminology
Methodology
Methods for the Determination of Adsorption Isotherms
Operational Definitions of Adsorption
Experimental Procedures
Outgassing the Adsorbent
Determination of the Adsorption Isotherm
Evaluation of Adsorption Data
Presentation of Primary Data
Classification of Adsorption Isotherms
Adsorption Hysteresis
Determination of Surface Area
Application of the BET Method
Empirical Procedures for Isotherm Analysis
Assessment of Mesoporosity
Properties of Porous Materials
Application of the Kelvin Equation
Computation of Mesopore Size Distribution
Assessment of Microporosity
Terminology
Concept of Surface Area
Assessment of Micropore Volume
General Conclusions and Recommendations
Keywords:
physisorption data;
IUPAC;
adsorption isotherms;
surface area;
BET isotherm
1,159 citations
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873 citations
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TL;DR: In this paper, it was shown that the amount of char and the incombustible gases that may be formed in thermal decomposition are very important quantitative measures of flame resistance.
855 citations
Authors
Showing all 6377 results
Name | H-index | Papers | Citations |
---|---|---|---|
J. Fraser Stoddart | 147 | 1239 | 96083 |
Eric P. Krenning | 103 | 411 | 34109 |
Oscar P. Kuipers | 101 | 593 | 41168 |
Thomas R. Gingeras | 100 | 249 | 91538 |
Matthias Wessling | 84 | 674 | 26409 |
Jan C. Hummelen | 81 | 278 | 42741 |
William Jones | 75 | 485 | 22558 |
D. W. Goodman | 72 | 319 | 21256 |
Jam Hans Kuipers | 69 | 360 | 18190 |
Frank C. J. M. van Veggel | 68 | 208 | 14331 |
Jaap M. Middeldorp | 68 | 270 | 15114 |
Ronald C. Montelaro | 66 | 287 | 14766 |
Hideaki Hara | 64 | 544 | 17518 |
Ulrich W. Suter | 63 | 286 | 14175 |
Thomas H. Hutchinson | 62 | 176 | 11537 |