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Institution

Alabama School of Fine Arts

EducationBirmingham, Alabama, United States
About: Alabama School of Fine Arts is a education organization based out in Birmingham, Alabama, United States. It is known for research contribution in the topics: Synechococcus & Prochlorococcus. The organization has 10 authors who have published 12 publications receiving 182 citations.

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Journal ArticleDOI
TL;DR: This study illustrates that it has the capability to place a range of antigenic epitopes within Ad5 capsid protein hexon hypervariable regions (HVRs) 2 or 5, thus producing viable Ad virions, and describes antigen placement and optimization within the context of the capsid incorporation approach of Ad vaccine employment, thereby broadening this new methodology.
Abstract: Despite the many potential advantages of Ad vectors for vaccine application, the full utility of current Ad vaccines may be limited by the host anti-vector immune response. Direct incorporation of antigens into the adenovirus capsid offers a new and exciting approach for vaccination strategies; this strategy exploits the inherent antigenicity of the Ad vector. Critical to exploiting Ad in this new context is the placement of antigenic epitopes within the major Ad capsid protein, hexon. In our current study we illustrate that we have the capability to place a range of antigenic epitopes within Ad5 capsid protein hexon hypervariable regions (HVRs) 2 or 5, thus producing viable Ad virions. Our data define the maximal incorporation size at HVR2 or HVR5 as it relates to identical antigenic epitopes. In addition, this data suggests that Ad5 HVR5 is more permissive to a range of insertions. Most importantly, repeated administration of our hexon-modified viruses resulted in a secondary anti-antigen response, whereas minimal secondary effect was present after administration of Ad5 control. Our study describes antigen placement and optimization within the context of the capsid incorporation approach of Ad vaccine employment, thereby broadening this new methodology.

54 citations

Journal ArticleDOI
TL;DR: In this paper, the authors report new geochemical evidence from ten Cretaceous-Tertiary boundary sites in North America and Europe, indicating the presence of a material remnant of a large asteroid or comet that struck the Earth at 65.0 Ma.
Abstract: -We report new geochemical evidence from ten Cretaceous-Tertiary (K-T) boundary sites in North America and Europe, indicating the presence of a material remnant of a large asteroid or comet that struck the Earth at 65.0 Ma. Mossbauer spectroscopic data reveals that a ubiquitous iron- rich nanophase material exists at the uppermost part of the K-T boundary layer in the Western Hemisphere and in Europe marine and continental fine-grained sedimentary rock. The high surface- to-volume ratio of nanophase material suggests that it may be the carrier of the iridium abundance enhancement that marks the K-T boundary. Even more provocative is the possibility that discovered nanophase material is, for the most part, composed of the vaporized impactor after the impact-generated high-temperature vapor plume rose and cooled above the atmosphere. INTRODUCTION In the last two decades, an enormous amount of chemical and physical evidence has been gathered that supports the idea that a large asteroid or comet struck Earth at

52 citations

Journal ArticleDOI
TL;DR: Among hospitalized NH residents, age 85 years or older and several acute conditions, but not chronic morbidities, predicted in-hospital mortality, and Elderly NH residents at risk of developing these acute conditions may benefit from palliative care.

26 citations

Journal ArticleDOI
01 Sep 2011-Carbon
TL;DR: In this article, a single-step synthesis of CNC heterostructures, comprised of carbon nanotubes (CNTs) decorated with nickel (Ni)/nickel oxide (NiO) core/shell nanoparticles through a direct nucleation approach is reported.

23 citations

Journal Article
TL;DR: In this article, a teacher preparation program should not only integrate technology throughout the curriculum, but also provide opportunities for the students to manage problems within the actual school setting as they integrate various tools of technology.
Abstract: Technology has permeated our educational experiences from electronic mail to virtual field trips by way of the Internet. As educators seek viable ways to use technology to enhance teaching and learning experiences, colleges must also prepare future teachers to plan for effective technology use. Teacher preparation programs should not only integrate technology throughout the curriculum, but should also provide opportunities for the students to manage problems within the actual school setting as they integrate various tools of technology.

19 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20211
20201
20182
20151
20111
20101