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Institution

Alberta Hospital Edmonton

HealthcareEdmonton, Alberta, Canada
About: Alberta Hospital Edmonton is a healthcare organization based out in Edmonton, Alberta, Canada. It is known for research contribution in the topics: Poison control & Population. The organization has 174 authors who have published 216 publications receiving 6828 citations.


Papers
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Journal ArticleDOI
TL;DR: The frontotemporal region, (posteroorbital-insulartemporopolar-pyriform-amygdaloid-rostral-hippocampal) was essentially a closed physiological system where discharges induced by electrical or strychnine stimulation tended to be confined to these limbic circuits.
Abstract: Impressed by the fact that rabies, with its predilection for hippocampal structures, presents with prominent mental symptoms: fear, terror, rage, insomnia, struck by the psychological changes accompanying tumors of the corpus callosum which encroached on the mesial aspect of the hemisphere and by the dysphoric states occurring with ischaemic lesions of the anterior cingulum, Papez, in 1937, stated his celebrated hypothesis. The hippocampus, fornix, mamilloanterior thalamic tract, and its projections to the cingulate gyri formed the anatomical substrate for emotion. MacLean in 1949 expanded the Papez circuit, showing that the septal nuclei, their brain stem connections via the medial forebrain bundle, the amygdaloid nuclei, and the insula were all, anatomically and functionally, part of the same complex neurophysiological system. This system he labeled ‘‘the limbic system’’ in 1952, emphasizing that the anterior cingulate and orbital-frontal components had important inhibitory functions as well as being crucial to autonomic regulation. MacLean also separated the amygdaloid subdivision of the limbic system, related to aggression and defense, from the septal subdivision, related to sexuality. Importantly, he stressed that the frontotemporal region, (posteroorbital-insulartemporopolar-pyriform-amygdaloid-rostral-hippocampal) was essentially a closed physiological system where discharges induced by electrical or strychnine stimulation tended to be confined to these limbic circuits. MacLean in 1970, because of the common symptomatology often seen in ‘‘smouldering limbic epilepsy’’

515 citations

Journal ArticleDOI
TL;DR: Olanzapine has some superior cognitive benefits relative to haloperidol and risperidone, and a larger sample replication study is necessary to confirm and generalize the observations of this study.
Abstract: Background The purpose of this investigation was to test the efficacy of novel antipsychotic medications in the treatment of cognitive impairment in early phase schizophrenia. Methods Sixty-five patients in this multicenter double-blind study were randomly assigned to olanzapine (5-20 mg), risperidone (4-10 mg), or haloperidol (5-20 mg). Standard measures of clinical and motor syndromes were administered, as well as a comprehensive battery of tests to assess (1) motor skills, (2) attention span, (3) verbal fluency and reasoning, (4) nonverbal fluency and construction, (5) executive skills, and (6) immediate recall at baseline and after 6, 30, and 54 weeks of treatment. Results The general cognitive index derived from the 6 domain scores revealed a significantly greater benefit from treatment with olanzapine relative to haloperidol and olanzapine relative to risperidone, but no significant difference was shown between risperidone and haloperidol. The improvement related to olanzapine was apparent after 6 weeks and enhanced after 30 and 54 weeks of treatment. Exploratory within-group analyses of the 6 cognitive domains after a conservative Bonferroni adjustment revealed a significant improvement with olanzapine only on the immediate recall domain, and similar analyses of the 17 individual tests revealed a significant improvement with olanzapine only on the Hooper Visual Organization Test. Conclusions These data suggest that olanzapine has some superior cognitive benefits relative to haloperidol and risperidone. A larger sample replication study is necessary to confirm and generalize the observations of this study and begin evaluation of the implications of this change to cerebral function and quality of life for people with schizophrenia.

476 citations

Journal ArticleDOI
TL;DR: The real time RT‐PCR assay is both simple and rapid with advantages including enhanced sensitivity and a lower risk for cross‐contamination making it a useful tool for the detection of rotavirus in various situations including sporadic gastroenteritis, outbreaks, and environmental investigations.
Abstract: Six-hundred and twenty-six stool specimens collected from children with diarrhea over a 12-month period were tested for rotavirus using a real time reverse transcription-polymerase chain reaction (RT-PCR) assay, a conventional nested PCR assay and by electron microscopy (EM) A fragment of 87 bp in a highly-conserved region of non-structural protein 3 (NSP3) in rotavirus genome was amplified by a single-step RT-PCR protocol in a closed-tube system Rotavirus was detected in 123 samples (20%) with the real time RT-PCR assay, 113 samples (18%) with the nested-PCR assay, and 79 samples (13%) with EM Using serial diluted nucleic acid extract, we compared the sensitivity of real time RT-PCR with conventional RT-PCR and conventional nested PCR assays Real time RT-PCR was two to four logs more sensitive than the conventional assays The reaction time required for the RT-PCR assay is about half the time required for the conventional nested-PCR The real time RT-PCR assay is both simple and rapid with advantages including enhanced sensitivity and a lower risk for cross-contamination making it a useful tool for the detection of rotavirus in various situations including sporadic gastroenteritis, outbreaks, and environmental investigations G(1) was the predominant type (89%), followed by G(2) (10%), and G(4) (1%) No rotavirus of G(3), G(8), and G(9) types were found The peak season for rotavirus infection was January to May in northern Alberta

222 citations

Journal ArticleDOI
TL;DR: In this article, the authors presented data stratified by age and sex for 12 neuro-psychological tests from a large neurologically intact, nonpsychiatric adult sample (127 males, 98 females, aged 15-40 years).
Abstract: Normative data stratified by age and sex are presented for 12 neuro-psychological tests from a large neurologically intact, nonpsychiatric adult sample (127 males, 98 females, aged 15–40 years). The tests include Language Modalities Test for Aphasia, Memory-for-Designs, Coloured Progressive Matrices, Symbol-Gestalt, Minute Estimation, Controlled Word Association, Written Word Fluency, Purdue Pegboard, Williams Clinical Memory, Symbol Digit Modalities, L. J. Tactile Recognition, and Wisconsin Card Sorting.

192 citations

Journal ArticleDOI
TL;DR: In this paper, the skeletal muscle cross-sectional area was measured with CT, and sarcopenia was defined with previously published sex- and body mass index-specific cutoffs.

184 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20224
20213
20204
20194
20181
20175