Showing papers by "Albion College published in 2016"

Implementing and innovating marine monitoring approaches for assessing marine environmental status

Abstract: Marine environmental monitoring has tended to focus on site-specific methods of investigation. These traditional methods have low spatial and temporal resolution and are relatively labor intensive per unit area/time that they cover. To implement the Marine Strategy Framework Directive (MSFD), European Member States are required to improve marine monitoring and design monitoring networks. This can be achieved by developing and testing innovative and cost-effective monitoring systems, as well as indicators of environmental status. Here, we present several recently developed methodologies and technologies to improve marine biodiversity indicators and monitoring methods. The innovative tools are discussed concerning the technologies presently utilized as well as the advantages and disadvantages of their use in routine monitoring. In particular, the present analysis focuses on: (i) molecular approaches, including microarray, Real Time quantitative PCR (qPCR), and metagenetic (metabarcoding) tools; (ii) optical (remote) sensing and acoustic methods; and (iii) in situ monitoring instruments. We also discuss their applications in marine monitoring within the MSFD through the analysis of case studies in order to evaluate their potential utilization in future routine marine monitoring. We show that these recently-developed technologies can present clear advantages in accuracy, efficiency and cost.

“Boys Don’t Cry”—or Do They? Adult Attitudes Toward and Beliefs About Transgender Youth

Abstract: The present survey study examined the attitudes of U.S. adults toward transgender children and adolescents, as well as their behavioral intentions, in two hypothetical scenarios involving gender variant youth. Participants recruited online (N = 281) reported generally favorable attitudes toward transgender minors, but expressed some hesitation to allow a transgender child to use the restroom aligned with their gender as opposed to their birth sex or to share a room with same gender peers on a school trip, possibly due to conflating gender identity with sexual orientation in these situations. Attitudes were less positive in respondents who reported a religious affiliation, conservative social political views, and stronger conformity to certain traditional gender norms—particularly in men. Even after controlling for these factors, stronger belief in environmental versus biological causes of transgender identity was linked to more negative attitudes. Participants’ behavioral intentions were driven partly by their attitudes and causal attributions, but also by their age and, at least for women, personal connections to the transgender community. We discuss implications for the discourse surrounding transgender youth and the need for educating the public on the development of gender identity as well as the difference between gender identity and sexual orientation.

When Higher Working Memory Capacity Hinders Insight.

Abstract: Higher working memory capacity (WMC) improves performance on a range of cognitive and academic tasks. However, a greater ability to control attention sometimes leads individuals with higher WMC to persist in using complex, attention-demanding approaches that are suboptimal for a given task. We examined whether higher WMC would hinder insight problem solving, which is thought to rely on associative processes that operate largely outside of close attentional control. In addition, we examined whether characteristics of the insight problems influence whether this negative relationship will be revealed. In Experiment 1, participants completed matchstick arithmetic problems, which require a similar initial problem representation for all problems. Higher WMC was associated with less accurate insight problem solving. In Experiment 2, participants completed insight word problems, which require substantially different representations for each problem. Higher WMC was again negatively associated with insight, but only after statistically controlling for shared variance between insight and incremental problem-solving accuracy. These findings suggest that WMC may benefit performance on fundamental processes common to both incremental and insight problem solving (e.g., initial problem representation), but hinder performance on the processes that are unique to insight (e.g., solution and restructuring). By considering the WMC of the individual, and the nature of the insight task, we may better understand the process of insight and how to best support it. (PsycINFO Database Record

Large Lecture Transformation: Adopting Evidence-Based Practices to Increase Student Engagement and Performance in an Introductory Science Course

Abstract: This study investigated students' attitudes, engagement, satisfaction, and performance in Introduction to Environmental Science after it was transformed from a typical large lecture to a student-centered learning environment. The instructors of the course collaborated with the Office of Teaching, Learning & Technology and radically redesigned the course by adopting evidence-based pedagogical methods and instructional technology to offer a rich active learning environment. Students' engagement, satisfaction, and performance in the transformed course were compared to the students in the same course that was traditionally taught in a previous semester in order to measure the effect of the transformed course on student learning. Four self-reported surveys and a focus group interview were administered during the semester, and performance scores, prior learning data, and demographic information were collected at the end of the semester. The assessment results indicate that the students in the transform...

Scleroderma dermal microvascular endothelial cells exhibit defective response to pro-angiogenic chemokines

Abstract: Objectives Angiogenesis plays a critical role in SSc (scleroderma). The aim of this study was to examine the expression of growth-regulated protein-γ (Gro-γ/CXCL3), granulocyte chemotactic protein 2 (GCP-2/CXCL6) and their receptor CXCR2 in endothelial cells (ECs) isolated from SSc skin and determine whether these cells mount an angiogenic response towards pro-angiogenic chemokines. The downstream signalling pathways as well as the pro-angiogenic transcription factor inhibitor of DNA-binding protein 1 (Id-1) were also examined. Methods Skin biopsies were obtained from patients with dcSSc. ECs were isolated via magnetic positive selection. Angiogenesis was measured by EC chemotaxis assay. Results Gro-γ/CXCL3 and GCP-2/CXCL6 were minimally expressed in both skin types but elevated in SSc serum. Pro-angiogenic chemokine mRNA was greater in SSc ECs than in normal ECs. SSc ECs did not migrate to vascular endothelial growth factor (VEGF), Gro-γ/CXCL3, GCP-2/CXCL6 or CXCL16. The signalling pathways stimulated by these chemokines were also dysregulated. Id-1 mRNA in SSc ECs was lower compared with normal ECs, and overexpression of Id-1 in SSc ECs increased their ability to migrate towards VEGF and CXCL16. Conclusion Our results show that SSc ECs are unable to respond to pro-angiogenic chemokines despite their increased expression in serum and ECs. This might be due to the differences in the signalling pathways activated by these chemokines in normal vs SSc ECs. In addition, the lower expression of Id-1 also decreases the angiogenic response. The inability of pro-angiogenic chemokines to promote EC migration provides an additional mechanism for the impaired angiogenesis that characterizes SSc.

Not all musicians are creative: Creativity requires more than simply playing music

Abstract: Musical training has been found to be associated with increased creativity. However, it is not clear whether increased creativity, particularly divergent thinking, is associated with music expertise due to knowledge and skill, or if increased creativity arises from participation in the creation of music through practices such as improvisation and composition. This study investigated how level of music expertise and engagement in the creation of music relate to divergent thinking in musically trained adults (musicians). Sixty participants of varying music expertise were tested for divergent thinking using a modified version of Guilford’s (1967) alternative uses task, in which participants listed creative uses for two music items and two non-music items. Results indicate that musicians who create music listed more creative uses for music items than non-musicians and musicians who do not create music. For non-music items, participants did not display differences in divergent thinking.

Who’s Who in Introductory Psychology Textbooks A Citation Analysis Redux

Abstract: It is important to assess periodically how introductory textbooks portray our discipline because introductory psychology is the most popular psychology course, almost all teachers use textbooks for it, and textbooks play a major role in defining the course for students. To do so, past studies have used textbook citation analyses. We analyzed current textbooks to update the citation findings of these studies for the most cited articles, books, and psychologists. Many highly cited articles and books have decreased in citation frequency, likely due to a currency bias and authors’ citation preferences. Freud had the highest citation page count, reinforcing students’ misconception of his importance in contemporary scientific psychology. Our findings should help teachers in making choices about course content and emphases.

Professional, Personal, and Relational: Exploring the Salience of Identity in Academic Careers

Abstract: This article explores the role of identity in lived experiences within the professoriate. While scholarship has given some attention to professional identity and personal identity, little in the literature has attempted to present a holistic view of identity and the complex ways that it defines and influences academic careers. The authors present findings from their analysis of interview data from 50 participants across career stages, from doctoral students to full professors. These findings suggest that three distinct but related, and potentially synergistic, components of identity are salient in shaping perceptions of and experiences within academic careers. The authors offer future directions for research centered on a rich conceptualization of identity as critical for understanding faculty development, experiences, and needs.

Drug Synthesis and Analysis on a Dime: A Capstone Medicinal Chemistry Experience for the Undergraduate Biochemistry Laboratory.

Abstract: Integrative, research-based experiences have shown tremendous potential as effective pedagogical approaches. Pharmaceutical development is an exciting field that draws heavily on organic chemistry and biochemistry techniques. A capstone drug synthesis/analysis laboratory is described where biochemistry students synthesize azo-stilbenoid compounds and test the biological activity of those compounds as well as a known inhibitor on mushroom tyrosinase using UV/vis-based kinetic assays. In this paper, three such successful azo-stilbenoid inhibitors of tyrosinase, representative student generated data, technical aspects of the experiments, and an interpretation of student feedback on the project as a whole are presented.

Protruding Features of Viral Capsids Are Clustered on Icosahedral Great Circles

Abstract: Spherical viruses are remarkably well characterized by the Triangulation (T) number developed by Casper and Klug. The T-number specifies how many viral capsid proteins are required to cover the virus, as well as how they are further subdivided into pentamer and hexamer subunits. The T-number however does not constrain the orientations of these proteins within the subunits or dictate where the proteins should place their protruding features. These protrusions often take the form of loops, spires and helices, and are significant because they aid in stability of the capsid as well as recognition by the host organism. Until now there has be no overall understanding of the placement of protrusions for spherical viruses, other than they have icosahedral symmetry. We constructed a set of gauge points based upon the work affine extensions of Keef and Twarock, which have fixed relative angular locations with which to measure the locations of these features. This work adds a new element to our understanding of the geometric arrangement of spherical viral capsid proteins; chiefly that the locations of protruding features are not found stochastically distributed in an icosahedral manner across the viral surface, but instead these features are found only in specific locations along the 15 icosahedral great circles. We have found that this result holds true as the T number and viral capsids size increases, suggesting an underlying geometric constraint on their locations. This is in spite of the fact that the constraints on the pentamers and hexamer orientations change as a function of T-number, as you need to accommodate more hexamers in the same solid angle between pentamers. The existence of this angular constraint of viral capsids suggests that there is a fitness or energetic benefit to the virus placing its protrusions in this manner. This discovery may have profound impacts on identifying and eliminating viral pathogens, understanding evolutionary constraints as well as bioengineering for capsid drug delivery systems. This result also suggests that in addition to biochemical attachment restrictions, there are additional geometric constraints that should be adhered to when modifying protein capsids.

Persistence of Physics and Engineering Students via Peer Mentoring, Active Learning, and Intentional Advising

Abstract: We have developed and implemented a low-cost peer-mentoring program that blends personal and academic support to help students achieve academic success in the introductory courses required for the Physics Major or the Dual-Degree Program in Engineering. As a result of this program, retention has increased among entering science, technology, engineering and mathematics students at Albion College as they move through the introductory classes, as shown by a 20 per cent increase in retention from first-semester to third-semester physics courses compared to years when this program was not in place.

An Economic Alternative to Improve Cybersecurity of E-government and Smart Cities

Abstract: While the rapid progress in smart city technologies are changing cities and the lifestyle of the people, there are increasingly enormous challenges in terms of the safety and security of smart cities. The potential vulnerabilities of e-government products and imminent attacks on smart city infrastructure and services will have catastrophic consequences on the governments and can cause substantial economic and noneconomic losses, even chaos, to the cities and their residents. This paper aims to explore alternative economic solutions ranging from incentive mechanisms to market-based solutions to motivate smart city product vendors, governments, and vulnerability researchers and finders to improve the cybersecurity of smart cities.

Stratigraphy, mammalian paleontology, paleoecology, and age correlation of the Wasatch Formation, Fossil Butte National Monument, Wyoming

Abstract: Fieldwork conducted in the Wasatch Formation in and around Fossil Butte has yielded a diverse assemblage of early Eocene vertebrates. Fossil vertebrates are distributed through three discrete stratigraphic intervals within the uppermost 180 m of the main body of the Wasatch Formation underlying the Green River Formation. These assemblages were derived primarily from fluvial overbank mudstone units overprinted with variably well-developed paleosols. The lowest (20 m) and highest (60 m) sections are characterized by less mature and more hydromorphic paleosols, whereas the middle section (100 m) is typified by more mature paleosols and more abundant channel sandstones. The combined assemblages contain at least 46 species of mammals. Faunal characteristics include high abundances of equid perissodactyls and a relatively high abundance and diversity of notharctines primates, an apparent absence of omomyid primates, relatively high rodent diversity, and relatively diverse and abundant artiodactyls. One new genus (Eoictops new genus) and three new species (Eoictops novaceki new species, Palaeosinopa lacus new species, and ?Notoparamys blochi new species) are included in the Fossil Butte assemblage. Also recorded are late occurrences of two hyopsodontid condylarths and an early occurrence of a rare phenacodontid condylarth. The relatively high abundances of equids and notharctines suggest that vertebrate samples were derived from relatively open paleohabitats that included forested areas along water courses. All three assemblages contain characteristic Lysitean (Wasatchian biochron Wa-6) elements, but the occurrence of the palaeotheriid perissodactyl Lambdotherium in the uppermost horizon indicates a Lostcabinian (Wa-7) age for at least the top of the Wasatch Formation. The overlying predominantly fish-bearing Fossil Butte Member of the Green River Formation also contains Lambdotherium and is therefore Wa-7 in age as well.

Persistence of physics and engineering students via peer mentoring, active learning, and intentional advising

Abstract: Albion College, a private, undergraduate-only, liberal arts college in Michigan, USA, has developed and implemented a low-cost peer-mentoring programme that blends personal and academic support to help students achieve academic success in the introductory courses required for the Physics Major or the Dual-Degree Program in Engineering. This enhanced mentoring programme provides much-needed assistance for undergraduate students to master introductory physics and mathematics coursework, to normalise the struggle of learning hard material, and to accept their identity as physics or engineering students (among other goals). Importantly, this programme has increased retention among entering science, technology, engineering and mathematics students at Albion College as they move through the introductory classes, as shown by a 20% increase in retention from first-semester to third-semester physics courses compared to years when this programme was not in place.

Putting Humpty-Dumpty Together: Clustering the Functional Dynamics of Single Biomolecular Machines Such as the Spliceosome.

Abstract: The spliceosome is a biomolecular machine that, in all eukaryotes, accomplishes site-specific splicing of introns from precursor messenger RNAs (pre-mRNAs) with high fidelity Operating at the nanometer scale, where inertia and friction have lost the dominant role they play in the macroscopic realm, the spliceosome is highly dynamic and assembles its active site around each pre-mRNA anew To understand the structural dynamics underlying the molecular motors, clocks, and ratchets that achieve functional accuracy in the yeast spliceosome (a long-standing model system), we have developed single-molecule fluorescence resonance energy transfer (smFRET) approaches that report changes in intra- and intermolecular interactions in real time Building on our work using hidden Markov models (HMMs) to extract kinetic and conformational state information from smFRET time trajectories, we recognized that HMM analysis of individual state transitions as independent stochastic events is insufficient for a biomolecular machine as complex as the spliceosome In this chapter, we elaborate on the recently developed smFRET-based Single-Molecule Cluster Analysis (SiMCAn) that dissects the intricate conformational dynamics of a pre-mRNA through the splicing cycle in a model-free fashion By leveraging hierarchical clustering techniques developed for Bioinformatics, SiMCAn efficiently analyzes large datasets to first identify common molecular behaviors Through a second level of clustering based on the abundance of dynamic behaviors exhibited by defined functional intermediates that have been stalled by biochemical or genetic tools, SiMCAn then efficiently assigns pre-mRNA FRET states and transitions to specific splicing complexes, with the potential to find heretofore undescribed conformations SiMCAn thus arises as a general tool to analyze dynamic cellular machines more broadly

Influence of zinc on bacterial populations and their proteolytic enzyme activities in freshwater environments: a cross-site comparison

Abstract: Temporal responses of indigenous bacterial populations and proteolytic enzyme (i.e., aminopeptidase) activities in the bacterioplankton assemblages from 3 separate freshwater environments were examined after exposure to various zinc (Zn) concentrations under controlled microcosm conditions. Zn concentrations (ranging from 0 to 10 μmol/L) were added to water samples collected from the Kalamazoo River, Rice Creek, and Huron River and examined for bacterial abundance and aminopeptidase activities at various time intervals over a 48 h incubation period in the dark. The results showed that the Zn concentrations did not significantly influence total bacterial counts directly; however, aminopeptidase activities varied significantly to increasing zinc treatments over time. Also, analysis of variance and linear regression analyses revealed significant positive relationships between bacterial numbers and their hydrolytic enzyme activities, suggesting that both probably co-vary with increasing Zn concentrations in aquatic systems. The results from this study serve as additional evidence of the ecological role of Zn as an extracellular peptidase cofactor on the dynamics of bacterial assemblages in aquatic environments.

On the economics of mobile content pre-staging

Abstract: The explosive demand for data in wireless devices has driven mobile carriers and the research community to seek nearly all intriguing technical and economic solutions to data demand problem. Content pre-staging is the idea to push content as close to the device as possible, either at the network edge or on the device itself in order to reduce bandwidth needs at peak demand times. We posit an interesting twist on this arrangement, namely to explore the economic implications if mobile device storage could be made available either by the user or indirectly by the wireless operator. We model the interplay between the mobile service carrier, the content provider, and end users as a Stackelberg game. Utilizing economic levers, the carrier sets the price for content providers to pre-stage content on mobile device storage, and provides monetary reward to compensate users for the usage of their mobile device storage. Through analyzing the impact of content localization on the economic well-being of all players, we demonstrate the improvement in network efficiency from the social welfare perspective. While the carrier may set prices strategically to retain a larger share of the increased profitability of the business, such practice benefits all the three parties in the game, i.e., users gain QoE and content; the carrier gains in saved capacity and new revenue; and the content provider gains in increased revenue and increased content access.

Running Wheel for Earthworms.

Abstract: We describe the construction and use of a running wheel responsive to the movement of the earthworm. The wheel employs readily available, inexpensive components and is easily constructed. Movement of the wheel can be monitored visually or via standard behavioral laboratory computer interfaces. Examples of data are presented, and possibilities for use in the teaching classroom are discussed.

How to Catch Capone: The Optimal Punishment of Interrelated Crimes

Abstract: This paper characterizes optimal criminal punishments when there are multiple interrelated crimes. Optimal punishments are functions of the extent to which related crimes are complements or substitutes weighted by their relative harms to society. The available empirical evidence on the relationship between index crimes in the United States suggests that tailoring criminal punishments properly to incorporate relationships between crimes could reduce the aggregate harm to victims by 3%, or about $8 billion dollars annually, holding enforcement expenditures fixed. The actual harm reduction of a marginal increase in arrests for an index crime is on average about 1.5-3 times greater than the harm reduction calculated without these effects.

Pigouvian Taxation with Costly Administration and Multiple Externalities

Abstract: This paper generalizes corrective taxation to settings with costly administration and many externalities. If administrative cost varies only with the pollution generating activity, the optimal tax is equal to the externality added to the marginal administrative cost, and the private market fully internalizes the externality and administrative cost. If, due to the nature of enforcement, administrative cost varies with tax rates, then optimal policy leaves some portion of externalities uncorrected. As a result, using taxes to modify complement and substitute activities will be welfare increasing. Optimal policy may include subsidizing some harmful activities in order to reduce levels of even more harmful substitutes. Similarly, if the optimal activity mix changes with the scale of production and if higher scales of production use less harmful activity mixes, subsidizing the output of a harmful production process may be optimal.