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Institution

Aligarh Muslim University

EducationAligarh, Uttar Pradesh, India
About: Aligarh Muslim University is a education organization based out in Aligarh, Uttar Pradesh, India. It is known for research contribution in the topics: Population & Adsorption. The organization has 8218 authors who have published 16416 publications receiving 289068 citations. The organization is also known as: AMU.


Papers
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Journal ArticleDOI
TL;DR: An overview of the various aspects of enzymology, enzyme catalysis, enzyme immobilization and modulation of enzyme activity with special emphasis on modulation through different types of nanoparticles including their synthesis, characterization and applications is given.

116 citations

Journal ArticleDOI
16 Oct 2014-PLOS ONE
TL;DR: The efficacy of naringenin that lead to cell death in epidermoid carcinoma cells via inducing ROS generation, mitochondrial depolarization, nuclear condensation, DNA fragmentation, cell cycle arrest in G0/G1 phase and caspase-3 activation is confirmed.
Abstract: A natural predominant flavanone naringenin, especially abundant in citrus fruits, has a wide range of pharmacological activities. The search for antiproliferative agents that reduce skin carcinoma is a task of great importance. The objective of this study was to analyze the anti-proliferative and apoptotic mechanism of naringenin using MTT assay, DNA fragmentation, nuclear condensation, change in mitochondrial membrane potential, cell cycle kinetics and caspase-3 as biomarkers and to investigate the ability to induce reactive oxygen species (ROS) initiating apoptotic cascade in human epidermoid carcinoma A431 cells. Results showed that naringenin exposure significantly reduced the cell viability of A431 cells (p<0.01) with a concomitant increase in nuclear condensation and DNA fragmentation in a dose dependent manner. The intracellular ROS generation assay showed statistically significant (p<0.001) dose-related increment in ROS production for naringenin. It also caused naringenin-mediated epidermoid carcinoma apoptosis by inducing mitochondrial depolarization. Cell cycle study showed that naringenin induced cell cycle arrest in G0/G1 phase of cell cycle and caspase-3 analysis revealed a dose dependent increment in caspase-3 activity which led to cell apoptosis. This study confirms the efficacy of naringenin that lead to cell death in epidermoid carcinoma cells via inducing ROS generation, mitochondrial depolarization, nuclear condensation, DNA fragmentation, cell cycle arrest in G0/G1 phase and caspase-3 activation.

116 citations

Journal ArticleDOI
TL;DR: Sub-inhibitory concentrations of the clove oil demonstrated statistically significant reduction of las- and rhl-regulated virulence factors such as LasB, total protease, chitinase and pyocyanin production, swimming motility and exopolysaccharide production, highlighting the promising anti-QS-dependent therapeutic function of cloveOil against P. aeruginosa.
Abstract: Quorum sensing (QS) plays an important role in virulence, biofilm formation and survival of many pathogenic bacteria including Pseudomonas aeruginosa. This signalling pathway is considered as novel and promising target for anti-infective agents. In the present investigation, effect of the Sub-MICs of clove oil on QS regulated virulence factors and biofilm formation was evaluated against P. aeruginosa PAO1 and Aeromonas hydrophila WAF-38 strain. Sub-inhibitory concentrations of the clove oil demonstrated statistically significant reduction of las- and rhl-regulated virulence factors such as LasB, total protease, chitinase and pyocyanin production, swimming motility and exopolysaccharide production. The biofilm forming capability of PAO1 and A. hydrophila WAF-38 was also reduced in a concentration-dependent manner at all tested sub-MIC values. Further, the PAO1-preinfected Caenorhabditis elegans displayed an enhanced survival when treated with 1.6% v/v of clove oil. The above findings highlight the promising anti-QS-dependent therapeutic function of clove oil against P. aeruginosa.

116 citations

Journal ArticleDOI
TL;DR: The materials examined in this work showed the radioactivity levels below the limit estimated from radium equivalent activity the criterion formula for gamma-activity suggested for acceptable radiation doses attributable to building materials in OECD countries.

116 citations

Journal ArticleDOI
TL;DR: In this article, two voltage-mode all-pass sections using a single third generation current conveyor (CCIII) are given. And a current-mode first-order all pass section requiring one capacitor and one resistor is also proposed.
Abstract: Two novel first order voltage-mode all-pass sections using a single third generation current conveyor (CCIII) are given. In addition the first circuit uses three resistors and one capacitor and the second circuit which is derived from the first circuit uses two resistors and one capacitor. A current-mode first order all-pass section requiring one capacitor and one resistor is also proposed. SPICE simulation results are incorporated to verify the theory.

116 citations


Authors

Showing all 8370 results

NameH-indexPapersCitations
Sandeep Kumar94156338652
Detlef W. Bahnemann8851748826
Gaurav Sharma82124431482
Sang Un Ahn8239122067
M. Irfan8024120154
M. Mohisin Khan7726617940
Nazeer Ahmad7414318305
Rajeev Kumar7229620848
Syed F. Ali7144618669
Ahmad Umar7174021014
Aamir Ahmad6325113404
Mohammad Athar6332914384
A. Ahmad Masoodi628012771
Shahid Husain6243714444
Mohd Danish Azmi6118613130
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202371
2022217
20211,667
20201,332
20191,208
20181,015