Aligarh Muslim University

About: Aligarh Muslim University is a education organization based out in Aligarh, Uttar Pradesh, India. It is known for research contribution in the topics: Population & Adsorption. The organization has 8218 authors who have published 16416 publications receiving 289068 citations. The organization is also known as: AMU.

Mechanistic insights into a novel chromone-appended Cu(II) anticancer drug entity: in vitro binding profile with DNA/RNA substrates and cytotoxic activity against MCF-7 and HepG2 cancer cells

Abstract: A new chromone-appended Cu(II) drug entity (1) was designed and synthesized as a potential anticancer chemotherapeutic agent. The structural elucidation was carried out thoroughly by elemental analysis, FT-IR, EPR, ESI-MS and single crystal X-ray crystallography. Complex 1 resulted from the in situ methoxylation reaction of the 3-formylchromone ligand and its subsequent complexation with the copper nitrate salt in a 2 : 1 ratio, respectively. 1 crystallized in the monoclinic P21/c space group possessing the lattice parameters, a = 8.75 A, b = 5.07 A, c = 26.22 A, α = γ = 90°, β = 96.3° per unit cell. Furthermore, in vitro interaction studies of 1 with ct-DNA and tRNA were carried out which suggested more avid binding propensity towards the RNA target via intercalative mode, which was reflected from its Kb, K and Ksv values. The gel electrophoretic mobility assay was carried out on the pBR322 plasmid DNA substrate, to ascertain the cleaving ability and the mechanistic pathway in the presence of additives, and the results revealed the efficient cleaving ability of 1via the oxidative pathway. In vitro cell growth inhibition via the MTT assay was carried out to evaluate the cytotoxicity of complex 1 and IC50 values were found to be in the range of 5–10 μg mL−1 in HepG2 and MCF-7 cancer cell lines, which were found to be much lower than the IC50 values of previously reported similar Cu(II) complexes. Additionally, in the presence of 1, reactive oxygen species (ROS) and thiobarbituric acid reactive substance (TBARS) levels in the tested cancer cell lines increased significantly, coupled with reduced glutathione (GSH) levels. Thus, our results suggested that ROS plays an important role in cell apoptosis induced by the Cu(II) complex 1 and validates its potential to act as a robust anticancer drug entity.

Effects of heavy metal toxicity on growth, symbiosis, seed yield and metal uptake in pea grown in metal amended soil.

Abstract: Soils contaminated with heavy metals present a major threat to sustainable agriculture. Understanding the effects of these metals on pea productivity will be useful. We studied the effects of cadmium, chromium and copper used both separately and as mixtures, on over all growth of pea plants inoculated with Rhizobium sp. Among the metals, copper was most toxic for pea plants and decreased the seed yield by 15% at 1,338 mg kg−1 compared to control plants whereas cadmium and chromium in general, increased the measured parameters. The metal accumulation in roots and shoots at 90 d and in grains at 120 d differed among treatments.

Coincidence and common fixed point theorems for nonlinear contractions in Menger PM spaces

Abstract: In this paper, we prove some existence results on coincidence and common fixed points of two pairs of self mappings without continuity under relatively weaker commutativity requirement in Menger PM spaces. Our results generalize many known results in Menger as well as metric spaces. Some related results are also derived besides furnishing illustrative examples.