Institution
Altran
Company•Neuilly-sur-Seine, France•
About: Altran is a company organization based out in Neuilly-sur-Seine, France. It is known for research contribution in the topics: Software development & Formal verification. The organization has 488 authors who have published 512 publications receiving 6395 citations.
Topics: Software development, Formal verification, Domain-specific language, Convection, Formal specification
Papers published on a yearly basis
Papers
More filters
••
TL;DR: The results of this study suggest that these novel bioresponsive antimicrobial polymers or similar analogs show promise for use in the control of medical device associated infections.
208 citations
••
TL;DR: A fully automatic processing combination of Active-Appearance-Model-based facial expression, vision-based eye-activity estimation, acoustic features, linguistic analysis, non-linguistic vocalisations, and temporal context information in an early feature fusion process is introduced.
193 citations
••
TL;DR: It is suggested that taurolidine-citrate is a promising combination agent for the prevention and treatment of intravascular catheter-related infections.
Abstract: Intravascular catheter-associated bloodstream infections significantly increase rates of morbidity and hospital costs. Microbial colonization and development of biofilms, which are known to be recalcitrant to antibiotic therapy, often lead to the loss of otherwise patent vascular access systems. We evaluated a new taurolidine- and citrate-based catheter lock solution (Neutrolin; Biolink Corporation, Norwell, Mass.) for its activity against planktonic microbes, antimicrobial activity in a catheter model, and biofilm eradication activity. In studies of planktonic microbes, after 24 h of contact, 675 mg of taurolidine-citrate solution per liter caused > 99% reductions in the initial counts of Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Entercoccus faecalis. A solution of 13,500 mg/liter was cidal for Candida albicans. Ports and attached catheters inoculated with 50 to 600 CFU of these bloodstream isolates per ml were locked with heparin or the taurolidine-citrate solution. After 72 h, there was no growth in the taurolidine-citrate-treated devices but the heparin-treated devices exhibited growth in the range of 6 x 10(2) to 5 x 10(6) CFU/ml. Biofilms were developed on silicone disks in modified Robbins devices with broth containing 6% serum (initial counts, 10(6) to 10(8) CFU/cm(2)). The axenic biofilms were treated for 24 h with taurolidine-citrate or heparin. Taurolidine-citrate exposure resulted in a median reduction of 4.8 logs, whereas heparin treatment resulted in a median reduction of 1.7 logs (P < 0.01). No significant differences in the effects of the two treatments against P. aeruginosa and C. albicans were observed. These findings suggest that taurolidine-citrate is a promising combination agent for the prevention and treatment of intravascular catheter-related infections.
187 citations
••
TL;DR: In this paper, the authors focus on the most common type of IG waves, those induced by the presence of groups in incident short waves, and three related mechanisms explain their generation: (1) the development, shoaling and release of waves bound to the short-wave group envelopes (2) the modulation by these envelopes of the location where short waves break, and (3) the merging of bores (breaking wave front, resembling to a hydraulic jump) inside the surfzone.
149 citations
••
TL;DR: The present review article summarizes the most important factors that influence efficient TES, presents and discusses currently used electrode materials, designs and configurations, and points out findings that have been obtained through modeling, simulation and testing.
Abstract: In therapeutic and functional applications transcutaneous electrical stimulation (TES) is still the most frequently applied technique for muscle and nerve activation despite the huge efforts made to improve implantable technologies. Stimulation electrodes play the important role in interfacing the tissue with the stimulation unit. Between the electrode and the excitable tissue there are a number of obstacles in form of tissue resistivities and permittivities that can only be circumvented by magnetic fields but not by electric fields and currents. However, the generation of magnetic fields needed for the activation of excitable tissues in the human body requires large and bulky equipment. TES devices on the other hand can be built cheap, small and light weight. The weak part in TES is the electrode that cannot be brought close enough to the excitable tissue and has to fulfill a number of requirements to be able to act as efficient as possible. The present review article summarizes the most important factors that influence efficient TES, presents and discusses currently used electrode materials, designs and configurations, and points out findings that have been obtained through modeling, simulation and testing.
145 citations
Authors
Showing all 489 results
Name | H-index | Papers | Citations |
---|---|---|---|
Khellil Sefiane | 52 | 292 | 8195 |
Jose L. Salmeron | 30 | 84 | 3207 |
Catherine Azzaro-Pantel | 28 | 168 | 2401 |
Ivan Kurtev | 25 | 53 | 4954 |
Jan Olaf Blech | 20 | 131 | 1134 |
Jacopo Belfi | 20 | 76 | 1045 |
Laura Rossi | 18 | 42 | 1498 |
M. Klein-Wolt | 18 | 30 | 1601 |
Hao Lu | 18 | 73 | 1019 |
Xiaoye Han | 17 | 61 | 883 |
Ivan Miguel Pires | 16 | 103 | 789 |
Luis A. S. de A. Prado | 13 | 17 | 678 |
Patricia Zunino | 11 | 24 | 716 |
Jon Arrospide | 11 | 19 | 481 |
Roderick Chapman | 11 | 18 | 651 |