Showing papers by "American Cancer Society published in 1975"

Major trends in cancer:25 year survey

Abstract: > The overall incidence of cancer (ex cluding carcinoma in situ of the uterine cervix and non-melanoma skin cancer) has decreased slightly during this period. Cancers of the stomach, esopha gus, rectum, uterus, ovary and blad der (female) have declined, while cancers of the lung, pancreas, colon (male), prostate and bladder (male) have increased. Clearly, significant progress has been made. Twenty-five years ago, one in four patients with cancer survived five years. Today, one in three will be saved, a gain of some 55,000 lives each year.

Genetics of somatic cell surface antigens. III. Further analysis of the AL marker.

Abstract: The AL antigen present on the surface of various human somatic cells, and on those hybrids of human and Chinese hamster ovary cells which have retained human chromosome number 11, has been resolved into at least two separate antigenic activities, a1 and a2. Specific antisera active against each antigen separately have been prepared. By treatment of the original AL+ hybrid with mutagenic agents and selection in particular antisera, stable clones are preparable whose phenotypic behavior corresponds to the antigenic compositions a1+ a2−, a1− a2+, and a1− a2−. The adsorption behavior of these variants for specific antisera is consistent with their phenotypic assignments.

Non-hodgkin's lymphoma in children: Correlation of CNS disease with initial presentation

Abstract: The clinical and histopathological findings in 26 children with non-Hodgkin's lymphoma without initial marrow involvement are reviewed. A marked male predominance similar to that observed in previous series was noted. Biopsy material was classified according to the recommendations of Rappaport in 22 cases. All have diffuse lymphomas, and 16 of 22 patients had diffuse, poorly-differentiated, lymphocytic lymphoma. Twelve of 26 patients had involvement of the mediastinum as part of their initial presentation. Of these 12, 5 developed lymphomatous involvement of the central nervous system prior to the development of leukemic transformation of the bone marrow. This observation suggests that prophylactic therapy against CNS relapse be considered for children with mediastinal non-Hodgkin's lymphoma, even in the absence of initial marrow involvement.

Hodgkin's disease in childhood

Abstract: A retrospective study of 116 children with Hodgkin's disease diagnosed in the period 1935–1970 was undertaken to assess the prognostic role of histopathologic classification and clinical extent of the disease. The ages of the 80 boys and 36 girls ranged from 2.5 years to 15.0 years (mean, 10.0 years). The histopathologic diagnosis by lymph node biopsy revealed lymphocyte predominance in 22, nodular sclerosis in 67, mixed cellularity in 24, and lymphocyte depletion in 3. Within the subgroup of nodular sclerosis, 47 biopsies had classic well-developed collagenous bands, whereas 20 were in the cellular phase (10 without collagenous bands and 10 with minimal collagen). The clinical extent of disease was determined. There were 33 patients with Stage I disease, 38 with Stage IIA, 12 with Stage IIB, 24 with Stage III, and 9 with Stage IV. Survival correlated with histopathologic type and clinical stage, but not with age or sex. Survival was not dependent on the degree of collagenization in nodular sclerosis. There were 29 patients who survived for more than 10 years. Four of these 29 subsequently died owing to acute myelomonocytic leukemia, carcinoma of the breast, sepsis, and progression of Hodgkin's disease, respectively. Neoplasms developed in two other long-term survivors (thyroid carcinoma in one, and multiple basal cell carcinomas in the other).

The synthesis of trideuterated diethylstilbestrol ([1,1,1-D3] E-3,4-di-(4-hydroxyphenyl)-hex-3-ene)†

Abstract: [1,1,1-D3] E-3,4-Di-(4-hydroxyphenyl)-hex-3-ene has been synthesized from 1,2-di-(4-methoxyphenyl)-butan-1-one. Reaction of this ketone with [2,2,2-D3] ethyl magnesium iodide yields [1,1,1-D3]3,4-di-(4-methoxyphenyl)-hexan-3-ol, which on dehydration with potassium hydrogen sulfate and demethylation with methyl magnesium iodide yields isotopically pure trideuterated diethyl-stilbestrol. Isotopically pure [2,2-D2] 3,4-di-(4-dydroxyphenyl)-hex-3-ene cannot be prepared by this route from [1,1-D2] ethyl magnesium iodide.

Ultrasound in the Evaluation and Diagnosis of Ovarian Tumors

Abstract: Diagnostic ultrasound by contact compound B-mode echographic scanning is used at the M. D. Anderson Hospital and Tumor Institute to assist in the diagnosis and management of patients with ovarian tumors. The usefulness of ultrasound for the diagnosis of solid or cystic lesions has been verified by various investigators.(4) Due to the difficulty in following patients with ovarian tumors on a clinical basis alone, the value of diagnostic ultrasound was investigated in following tumors for size, regression or enlargement, recurrence or further extension. In addition ascites, omental metastasis, or lymph node involvement were also evaluated.