Amirkabir University of Technology

About: Amirkabir University of Technology is a education organization based out in Tehran, Iran. It is known for research contribution in the topics: Nonlinear system & Fuzzy logic. The organization has 15254 authors who have published 31165 publications receiving 487551 citations. The organization is also known as: Tehran Polytechnic & Tehran Polytechnic University.

A novel particle swarm optimization algorithm with adaptive inertia weight

Abstract: Particle swarm optimization (PSO) is a stochastic population-based algorithm motivated by intelligent collective behavior of some animals. The most important advantages of the PSO are that PSO is easy to implement and there are few parameters to adjust. The inertia weight (w) is one of PSO's parameters originally proposed by Shi and Eberhart to bring about a balance between the exploration and exploitation characteristics of PSO. Since the introduction of this parameter, there have been a number of proposals of different strategies for determining the value of inertia weight during a course of run. This paper presents the first comprehensive review of the various inertia weight strategies reported in the related literature. These approaches are classified and discussed in three main groups: constant, time-varying and adaptive inertia weights. A new adaptive inertia weight approach is also proposed which uses the success rate of the swarm as its feedback parameter to ascertain the particles' situation in the search space. The empirical studies on fifteen static test problems, a dynamic function and a real world engineering problem show that the proposed particle swarm optimization model is quite effective in adapting the value of w in the dynamic and static environments.

The capacitated lot sizing problem: a review of models and algorithms

Abstract: Lot sizing is one of the most important and also one of the most difficult problems in production planning. This subject has been studied extensively in the literature. In this article, we consider single-level lot sizing problems, their variants and solution approaches. After introducing factors affecting formulation and the complexity of production planning problems, and introducing different variants of lot sizing and scheduling problems, we discuss single-level lot sizing problems, together with exact and heuristic approaches for their solution. We conclude with some suggestions for future research.

LRP6 Mutation in a Family with Early Coronary Disease and Metabolic Risk Factors

Abstract: Coronary artery disease (CAD) is the leading cause of death worldwide and is commonly caused by a constellation of risk factors called the metabolic syndrome. We characterized a family with autosomal dominant early CAD, features of the metabolic syndrome (hyperlipidemia, hypertension, and diabetes), and osteoporosis. These traits showed genetic linkage to a short segment of chromosome 12p, in which we identified a missense mutation in LRP6, which encodes a co-receptor in the Wnt signaling pathway. The mutation, which substitutes cysteine for arginine at a highly conserved residue of an epidermal growth factor-like domain, impairs Wnt signaling in vitro. These results link a single gene defect in Wnt signaling to CAD and multiple cardiovascular risk factors.