Institution
Annamalai University
Education•Chidambaram, Tamil Nadu, India•
About: Annamalai University is a education organization based out in Chidambaram, Tamil Nadu, India. It is known for research contribution in the topics: Lipid peroxidation & Antioxidant. The organization has 8098 authors who have published 10758 publications receiving 203872 citations.
Papers published on a yearly basis
Papers
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TL;DR: The study revealed the phosphate solubilizing potential of Trichoderma, which has the potential to improve soil fertility and mangrove growth.
91 citations
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TL;DR: It is indicated that low levels of GSH, GPx, GST, SOD, vitamin E and vitamin C in the circulation of cervical cancer patients may be due to their increased utilization to scavenge lipid peroxides as well as their sequestration by tumor cells.
90 citations
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TL;DR: Some novel benzoxazolylethoxypiperidones have been synthesized and their antibacterial activity against streptococcus faecalis, bacillus subtilis, escherichia coli, staphylococcus aureus aand pseudomonas aeruginosa and antifungal activity against Candida-6 and Aspergillus niger were evaluated.
90 citations
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TL;DR: It is demonstrated for the first time that chronic ASX administration improves insulin sensitivity by activating the post-receptor insulin signaling and by reducing oxidative stress, lipid accumulation and proinflammatory cytokines in obese mice.
Abstract: Astaxanthin (ASX), a xanthophyll carotenoid from the marine algae Hematococcus pluvialis, has anti-obesity and insulin-sensitivity effects. The specific molecular mechanisms of its actions are not yet established. The present study was designed to investigate the mechanisms underlying the insulin sensitivity effects of ASX in a non-genetic insulin resistant animal model. A group of male Swiss albino mice was divided into two and fed either a starch-based control diet or a high fat-high fructose diet (HFFD). Fifteen days later, mice in each dietary group were divided into two and were treated with either ASX (6 mg kg−1 per day) in olive oil or olive oil alone. At the end of 60 days, glucose, insulin and pro-inflammatory cytokines in plasma, lipids and oxidative stress markers in skeletal muscle and adipose tissue were assessed. Further, post-receptor insulin signaling events in skeletal muscle were analyzed. Increased body weight, hyperglycemia, hyperinsulinemia and increased plasma levels of tumor necrosis factor-α and interleukin-6 observed in HFFD-fed mice were significantly improved by ASX addition. ASX treatment also reduced lipid levels and oxidative stress in skeletal muscle and adipose tissue. ASX improved insulin signaling by enhancing the autophosphorylation of insulin receptor-β (IR-β), IRS-1 associated PI3-kinase step, phospho-Akt/Akt ratio and GLUT-4 translocation in skeletal muscle. This study demonstrates for the first time that chronic ASX administration improves insulin sensitivity by activating the post-receptor insulin signaling and by reducing oxidative stress, lipid accumulation and proinflammatory cytokines in obese mice.
90 citations
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TL;DR: The present study investigated the extracellular biosynthesis of antimicrobial silver nanoparticles by Escherichia coli and Aspergillus niger derived from coastal mangrove sediment of southeast India, finding that the antimicrobial activity of E. coli was more pronounced than that of A. niger and was enhanced with the addition of polyvinyl alcohol as a stabilizing agent.
Abstract: The present study investigated the extracellular biosynthesis of antimicrobial silver nanoparticles by Escherichia coli AUCAS 112 and Aspergillus niger AUCAS 237 derived from coastal mangrove sediment of southeast India. Both microbial species were able to produce silver nanoparticles, as confirmed by X-ray diffraction spectrum. The nanoparticles synthesized were mostly spherical, ranging in size from 5 to 20 nm for E. coli and from 5 to 35 nm for A. niger, as evident by transmission electron microscopy. Fourier transform spectroscopy revealed prominent peaks corresponding to amides I and II, indicating the presence of a protein for stabilizing the nanoparticles. Electrophoretic analysis revealed the presence of a prominent protein band with a molecular mass of 45 kDa for E. coli and 70 kDa for A. niger. The silver nanoparticles inhibited certain clinical pathogens, with antibacterial activity being more distinct than antifungal activity. The antimicrobial activity of E. coli was more pronounced than that of A. niger and was enhanced with the addition of polyvinyl alcohol as a stabilizing agent. This work highlighted the possibility of using microbes of coastal origin for synthesis of antimicrobial silver nanoparticles.
90 citations
Authors
Showing all 8164 results
Name | H-index | Papers | Citations |
---|---|---|---|
Dinesh Mohan | 79 | 283 | 35775 |
Sampath Parthasarathy | 77 | 268 | 34280 |
Mandyam V. Srinivasan | 68 | 344 | 15572 |
Leelavinothan Pari | 58 | 160 | 8374 |
Venugopal P. Menon | 54 | 195 | 10111 |
Kadarkarai Murugan | 54 | 286 | 9280 |
V. Balasubramanian | 54 | 457 | 10951 |
Marimuthu Govindarajan | 52 | 212 | 6738 |
Annamalai Subramanian | 49 | 95 | 6021 |
Meenakshisundaram Swaminathan | 48 | 239 | 8698 |
Siddavaram Nagini | 47 | 185 | 7371 |
Mohan K. Balasubramanian | 47 | 130 | 6238 |
Subash C. B. Gopinath | 45 | 455 | 7855 |
Sunil Sazawal | 44 | 111 | 9774 |
Al. Ramanathan | 43 | 235 | 6132 |