Annamalai University

About: Annamalai University is a education organization based out in Chidambaram, Tamil Nadu, India. It is known for research contribution in the topics: Lipid peroxidation & Antioxidant. The organization has 8098 authors who have published 10758 publications receiving 203872 citations.

Synthesis and characterization of silver nanoparticles using Gmelina asiatica leaf extract against filariasis, dengue, and malaria vector mosquitoes

Abstract: Mosquitoes are blood-feeding insects and serve as the most important vectors for spreading human diseases such as malaria, yellow fever, dengue fever, and filariasis The continued use of synthetic insecticides has resulted in resistance in mosquitoes Synthetic insecticides are toxic and affect the environment by contaminating soil, water, and air, and then natural products may be an alternative to synthetic insecticides because they are effective, biodegradable, eco-friendly, and safe to environment Botanical origin may serve as suitable alternative biocontrol techniques in the future The present study was carried out to establish the larvicidal potential of leaf extracts of Gmelina asiatica and synthesized silver nanoparticles using aqueous leaf extract against late third instar larvae of Anopheles stephensi, Aedes aegypti, and Culex quinquefasciatus Larvae were exposed to varying concentrations of plant extracts and synthesized AgNPs for 24 h The results were recorded from UV–visible spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, and energy-dispersive X-ray spectroscopy analysis support the biosynthesis and characterization of AgNPs The maximum efficacy was observed in synthesized AgNPs against the larvae of An stephensi (lethal dose (LC50) = 2244 μg/mL; LC90 4065 μg/mL), Ae aegypti (LC50 = 2577 μg/mL; LC90 4598 μg/mL), and C quinquefasciatus (LC50 = 2783 μg/mL; LC90 4892 μg/mL), respectively No mortality was observed in the control This is the first report on mosquito larvicidal activity of plant-synthesized nanoparticles Thus, the use of G asiatica to synthesize silver nanoparticles is a rapid, eco-friendly, and a single-step approach and the AgNps formed can be potential mosquito larvicidal agents

Anti-inflammatory role of naringenin in rats with ethanol induced liver injury.

Abstract: The aim of the study was to investigate the antiinflammatory effects of naringenin in rats induced liver damage by exposure to ethanol. Rats were divided into four groups, groups 1 and 2 received isocaloric glucose; groups 3 and 4 received 20% ethanol equivalent to 6 g/kg body weight everyday for the total experimental period of 60 days. In addition, groups 2 and 4 were supplemented with naringenin (50 mg/kg p.o.) everyday for the last 30 days of the experiment. The results showed significantly elevated levels/activities/expression of serum aspartate and alanine transaminases, iron, ferritin, transforming growth factor-alpha (TNF-α), interleukin-6 (IL-6), nuclear factor-kappa B (NF-κB), cyclooxygenase-2 (COX-2), macrophage inflammatory protein 2 (MIP-2) and CD14 in ethanol fed rats as compared to those of the control. Ethanol-fed rats exhibited increased staining for the presence of inducible nitric oxide (iNOS) protein adducts in the liver. Supplementation with naringenin for the last 30 days to ethanol-...