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Institution

Annamalai University

EducationChidambaram, Tamil Nadu, India
About: Annamalai University is a education organization based out in Chidambaram, Tamil Nadu, India. It is known for research contribution in the topics: Lipid peroxidation & Antioxidant. The organization has 8098 authors who have published 10758 publications receiving 203872 citations.


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Journal ArticleDOI
TL;DR: Results highlight that N. physalodes-fabricated Ag NPs are a promising for development of eco-friendly larvicides against mosquito vectors, with negligible toxicity against non-target aquatic water bugs.

81 citations

Journal ArticleDOI
TL;DR: Findings indicate that morin exert antioxidant potential and offer protection against ammonium chloride-induced hyperammonemia, but the exact underlying mechanism needs to be elucidated.
Abstract: Plant flavonoids are emerging as potent therapeutic drugs effective against a wide range of free radical-mediated diseases. Morin (3,5,7,2′,4′-pentahydroxyflavone), a member of flavonols, is an important bioactive compound by interacting with nucleic acids, enzymes and protein. In this study, we found that morin (30 mg/kg body weight) by oral administration offers protection against hyperammonemia by means of reducing blood ammonia, oxidative stress and enhancing antioxidant status in ammonium chloride-induced (100 mg/kg body weight; i.p) hyperammonemic rats. Enhanced blood ammonia, plasma urea, lipid peroxidation in circulation and tissues (liver and brain) of ammonium chloride-treated rats was accompanied by a significant decrease in the tissues levels of superoxide dismutase (SOD), catalase, reduced glutathione (GSH) and glutathione peroxidase (GPx). Morin administered rats showed a significant reduction in ammonia, urea, lipid peroxidation with a simultaneous elevation in antioxidant levels. Cotreatment with morin prevented the elevation of liver marker enzymes induced by ammonium chloride. The body weight of the animals decreased significantly on ammonium chloride administration when compared with control group. However, cotreatment with morin significantly prevented the decrease of the body weight caused by ammonium chloride. Hyperammonemic rats show liver fibrosis, steatosis, sinusoidal dilatation, etc., along with necrosis, microcystic degeneration in brain. All these changes were reduced in hyperammonemic rats treated with Morin, which too correlated with the biochemical observations. In conclusion, these findings indicate that morin exert antioxidant potential and offer protection against ammonium chloride-induced hyperammonemia. But the exact underlying mechanism needs to be elucidated.

81 citations

Journal ArticleDOI
TL;DR: The authors examined Protestant Work Ethic (PWE) and Just World Beliefs (JWB) in Great Britain and India and found that females more than males, Indians more than Britons, and schoolchildren more than adults endorse the PWE and JWB.
Abstract: This study examined Protestant Work Ethic (PWE) and Just World Beliefs (JWB) in Great Britain and India. Secondary school children, university students and adults completed seven PWE questionnaires and the JWB questionnaire. A three-way (sex × occupational status × nationality) ANOVA showed highly significant main effects, particularly for nationality, but few significant interactions. Generally females more than males, Indians more than Britons, and schoolchildren more than adults endorse the PWE and JWB. Possible experimental artifacts and moderator variables are considered along with the possibility that genuine cultural differences were found. These results are discussed in terms of the relevant literature on cross-cultural studies of the PWE and BJW. Cette etude a examine en Grande-Bretagne et en Inde le concept d'ethique protestante du travail, ainsi que la croyance en un monde juste. Des ecoliers du niveau secondaire, des etudiants universitaires et des adultes ont cornplete sept questionn...

81 citations

Journal ArticleDOI
TL;DR: Results indicate the neuroprotective effect of P. betle in ethanol-treated rats, which resulted in significant reduction of lipid levels and lipid peroxidation markers such as thiobarbituric acid reactive substances and hydroperoxides and antioxidants, like reduced glutathione, vitamin C, vitamin E, superoxide dismutase, catalase, and glutathion peroxidase, were increased in P. Betle-coadministered rats.
Abstract: The protective effect of Piper betle, a commonly used masticatory, has been examined in the brain of ethanol-administered Wistar rats. Brain of ethanol-treated rats exhibited increased levels of lipids, lipid peroxidation, and disturbances in antioxidant defense. Subsequent to the experimental induction of toxicity (i.e., the initial period of 30 days), aqueous P. betle extract was simultaneously administered in three different doses (100, 200, and 300 mg kg-1) for 30 days along with the daily dose of alcohol. P. betle coadministration resulted in significant reduction of lipid levels (free fatty acids, cholesterol, and phospholipids) and lipid peroxidation markers such as thiobarbituric acid reactive substances and hydroperoxides. Further, antioxidants, like reduced glutathione, vitamin C, vitamin E, superoxide dismutase, catalase, and glutathione peroxidase, were increased in P. betle-coadministered rats. The higher dose of extract (300 mg kg-1) was more effective, and these results indicate the neuropr...

81 citations

Journal ArticleDOI
TL;DR: Findings suggest potential use and benefit of FA as a radioprotector on gamma radiation-induced dicentric aberration and lipid peroxidation with reference to alterations in cellular antioxidant status in cultured lymphocytes.
Abstract: In this study we examined radioprotective effect of ferulic acid (FA) on gamma radiation-induced dicentric aberration and lipid peroxidation with reference to alterations in cellular antioxidant status in cultured lymphocytes. To establish most effective protective support we used three different concentrations of FA (1, 5 and 10 μg/ml) and three different doses of γ-radiation (1, 2 and 4 Gy). Treatment of lymphocytes with FA alone (at 10 μg/ml) gave no significant change in micronuclei (MN), dicentric aberration (DC), thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) or glutathione peroxidase (GPx) activities when compared with normal lymphocytes; irradiation at 1, 2 and 4 Gy increased the MN and DC frequencies in a dose-dependent manner. Treatment with FA for 30 min before radiation exposure resulted in a significant decline of MN and DC yields as FA concentration increased. Compared to 1 Gy exposure alone, the extent to which FA (1 μg/ml) reduced the MN and DC yields was 75% and 50%, respectively. With 4 Gy irradiation, FA (10 μg/ml) decreased 45% MN and 25% DC frequencies. FA-pretreated lymphocytes (1, 5 and 10 μg/ml) showed progressively decreased TBARS levels after irradiation. Irradiation (1, 2 and 4 Gy) significantly decreased GSH levels, SOD, CAT and GPx activities in a dose-dependent manner. Pretreatment with 10 μg/ml of FA significantly (p

81 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202326
2022119
2021673
2020693
2019576
2018507