Institution
Annamalai University
Education•Chidambaram, Tamil Nadu, India•
About: Annamalai University is a education organization based out in Chidambaram, Tamil Nadu, India. It is known for research contribution in the topics: Lipid peroxidation & Antioxidant. The organization has 8098 authors who have published 10758 publications receiving 203872 citations.
Papers published on a yearly basis
Papers
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TL;DR: It is suggested that GA prevents oxidative damage and has a downregulatory effect on the inflammatory pathway in liver of fructose-fed rats.
70 citations
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TL;DR: Eugenol can potentially ameliorate key enzymes of glucose metabolism in experimental diabetes, and it is sensible to broaden the scale of use of eugenol in a trial to alleviate the adverse effects of diabetes.
Abstract: Epidemiological studies have demonstrated that diabetes mellitus is a serious health burden for both governments and healthcare providers. This study was hypothesized to evaluate the antihyperglycemic potential of eugenol by determine the activities of key enzymes of glucose metabolism in streptozotocin (STZ)-induced dia- betic rats. Diabetes was induced into male albino Wistar rats by intraperitoneal administration of STZ (40 mg/kg body weight (b.w.)). Eugenol was administered to diabetic rats intragastrically at 2.5, 5, and 10 mg/kg b.w. for 30 days. The dose 10 mg/kg b.w. significantly reduced the levels of blood glucose and glycosylated hemoglobin (HbA1c) and increased plasma insulin level. The altered activities of the key enzymes of carbohydrate metabolism such as hexokinase, pyruvate kinase, glucose-6-phosphate dehydrogenase, glucose-6-phosphatase, fructose-1,6-bis- phosphatase, and liver marker enzymes (AST, ALT, and ALP), creatine kinase and blood urea nitrogen in serum and blood of diabetic rats were significantly reverted to near normal levels by the administration of eugenol. Further, eugenol administration to diabetic rats improved body weight and hepatic glycogen content demonstrated the antihyperglycemic potential of eugenol in diabetic rats. The present findings suggest that eugenol can potentially ameliorate key enzymes of glucose metabolism in experi- mental diabetes, and it is sensible to broaden the scale of use of eugenol in a trial to alleviate the adverse effects of diabetes.
70 citations
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TL;DR: A facile solvothermal process is successfully developed to prepare F-center cubic Co3O4 nanoflakes in ethylene-glycol-water solvent and analyses ascertain that Co3 O4 nanocrystals are nanofLakes in nature and the particle size in SEM is exactly consistent with XRD results.
70 citations
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TL;DR: Findings suggest that RA acts as a vasoactive substance and a cardioprotector through its antioxidant property and may be useful in reducing the cardiovascular risk associated with IR.
Abstract: Rosmarinic acid (RA), a caffeic acid ester, has insulin-sensitizing and antioxidant effects in high fructose-fed model of insulin resistance (IR). This study investigated whether RA supplementation prevents cardiac abnormalities and hypertension in fructose-fed rats (FFR). Rats fed with fructose diet (60 g/100 g) for 60 days exhibited metabolic abnormalities and rise in plasma and cardiac lipids and whole body IR. The levels of cardiac antioxidants and plasma ferric reducing antioxidant power were significantly reduced in FFR concomitant with increased levels of lipid peroxidation and protein oxidation products. A significant rise in troponin T, creatine kinase-MB, aspartate transaminase, and lactate dehydrogenase in plasma of FFR was noted. RA supplementation to FFR (10 mg/kg from the 16th day) significantly improved insulin sensitivity, reduced lipid levels, oxidative damage, and the expression of p22phox subunit of nicotinamide adenine dinucleotide phosphate reduced oxidase, and prevented cardiac hypertrophy. Fructose-induced rise in blood pressure was also lowered by RA through decrease in endothelin-1 and angiotensin-converting enzyme activity and increase in nitric oxide levels. Histology revealed a reduction in myocardial damage in RA-supplemented FFR. These findings suggest that RA acts as a vasoactive substance and a cardioprotector through its antioxidant property. Thus, RA may be useful in reducing the cardiovascular risk associated with IR.
70 citations
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TL;DR: In this article, the relationship between the FSW process parameters (rotational speed, welding speed and axial force) and the responses (ultimate tensile strength, notch tensiles strength and weld nugget hardness) were established.
70 citations
Authors
Showing all 8164 results
Name | H-index | Papers | Citations |
---|---|---|---|
Dinesh Mohan | 79 | 283 | 35775 |
Sampath Parthasarathy | 77 | 268 | 34280 |
Mandyam V. Srinivasan | 68 | 344 | 15572 |
Leelavinothan Pari | 58 | 160 | 8374 |
Venugopal P. Menon | 54 | 195 | 10111 |
Kadarkarai Murugan | 54 | 286 | 9280 |
V. Balasubramanian | 54 | 457 | 10951 |
Marimuthu Govindarajan | 52 | 212 | 6738 |
Annamalai Subramanian | 49 | 95 | 6021 |
Meenakshisundaram Swaminathan | 48 | 239 | 8698 |
Siddavaram Nagini | 47 | 185 | 7371 |
Mohan K. Balasubramanian | 47 | 130 | 6238 |
Subash C. B. Gopinath | 45 | 455 | 7855 |
Sunil Sazawal | 44 | 111 | 9774 |
Al. Ramanathan | 43 | 235 | 6132 |