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Institution

Annamalai University

EducationChidambaram, Tamil Nadu, India
About: Annamalai University is a education organization based out in Chidambaram, Tamil Nadu, India. It is known for research contribution in the topics: Lipid peroxidation & Antioxidant. The organization has 8098 authors who have published 10758 publications receiving 203872 citations.


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Journal ArticleDOI
TL;DR: This paper reviews an in-depth study of the anticancer activity and the miscellaneous mechanisms underlying the anticarcinogenicity thereby broadening its therapeutic marvel.
Abstract: Rising evidence provides credible support towards the potential role of bioactive products derived from cruciferous vegetables such as broccoli, cauliflower, kale, cabbage, brussels sprouts, turnips, kohlrabi, bok choy, and radishes. Many epidemiological studies point out that Brassica vegetable protects humans against cancer since they are rich sources of glucosinolates in addition to possessing a high content of flavonoids, vitamins, and mineral nutrients. Indole-3-carbinol (I3C) belongs to the class of compounds called indole glucosinolate, obtained from cruciferous vegetables, and is well-known for tits anticancer properties. In particular, I3C and its dimeric product, 3,3′-diindolylmethane (DIM), have been generally investigated for their value against a number of human cancers in vitro as well as in vivo. This paper reviews an in-depth study of the anticancer activity and the miscellaneous mechanisms underlying the anticarcinogenicity thereby broadening its therapeutic marvel.

63 citations

Journal ArticleDOI
TL;DR: The results of the present study indicated that the DMC may serve as a potent therapeutic agent particularly for the treatment of neurodegenerative diseases like PD, further pre-clinical and clinical studies are required.
Abstract: Mitochondrial dysfunction and oxidative stress are the main toxic events leading to dopaminergic neuronal death in Parkinson’s disease (PD) and identified as vital objective for therapeutic intercession. This study investigated the neuro-protective effects of the demethoxycurcumin (DMC), a derivative of curcumin against rotenone induced neurotoxicity. SH-SY5Y neuroblastoma cells are divided into four experimental groups: untreated cells, cells incubated with rotenone (100 nM), cells treated with DMC (50 nM) + rotenone (100 nM) and DMC alone treated. 24 h after treatment with rotenone and 28 h after treatment with DMC, cell viability was assessed using the MTT assay, and levels of ROS and MMP, plus expression of apoptotic protein were analysed. Rotenone induced cell death in SH-SY5Y cells was significantly reduced by DMC pretreatment in a dose-dependent manner, indicating the potent neuroprotective effects of DMC. Rotenone treatment significantly increases the levels of ROS, loss of MMP, release of Cyt-c and expression of pro-apoptotic markers and decreases the expression of anti-apoptotic markers. Even though the results of the present study indicated that the DMC may serve as a potent therapeutic agent particularly for the treatment of neurodegenerative diseases like PD, further pre-clinical and clinical studies are required.

63 citations

Journal ArticleDOI
TL;DR: The protective effects of SA are mediated by reducing oxidative stress and retaining the bioavailability of NO in the cardiovascular system, and are substantiated by the histological observation.
Abstract: The objective of the present study was to investigate the effects of syringic acid (SA), a phenolic acid, on Nω-nitro-l-arginine methyl ester (l-NAME)-induced hypertensive rats. Hypertension was induced in adult male albino rats by oral administration of l-NAME (40 mg/kg/day) dissolved in drinking water daily for 4 weeks. Rats were treated with different doses of SA (25, 50, and 100 mg/kg body weight (b.w.)). Systolic blood pressure of control and experimental rats was recorded. Plasma nitric oxide metabolites (NOx), lipid peroxidative products such as thiobarbituric acid reactive substances, lipid hydroperoxides, conjugated dienes, and antioxidants such as superoxide dismutase, catalase, glutathione peroxidase, vitamin C, vitamin E, and reduced glutathione were estimated in erythrocytes, plasma, and tissues of experimental rats. Hepatic marker enzymes such as aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase and renal functional markers such as urea, uric acid, and creatinine were also estimated in serum. The increased levels of blood pressure, lipid peroxidation products, hepatic and renal function markers, and the decreased level of NOx and antioxidants in l-NAME-induced hypertensive rats were reversed upon SA treatment. The protective effect at the dose of the three tested doses (25, 50, and 100 mg/kg) of SA at a dose of 50 mg/kg b.w. exerts optimum protection. Biochemical findings are substantiated by the histological observation. The protective effects of SA are mediated by reducing oxidative stress and retaining the bioavailability of NO in the cardiovascular system.

63 citations

Journal ArticleDOI
TL;DR: In this article, a modified anaerobic sequential batch reactor (MASBR) was employed to treat the textile dyeing industry wastewater, which was observed over a period of 80 days, and experiments were performed at various organic loading rates by varying initial textile dye wastewater concentration and hydraulic retention time.
Abstract: In this study a novel modified anaerobic sequential batch reactor (MASBR) was employed to treat the textile dyeing industry wastewater. The anaerobic sequential batch reactor (ASBR) was modified by the addition of a sorbent (ground nut shell powder) and plastic media. The start-up phase of the MASBR was observed over a period of 80 days. Statistical based experiments were performed in order to optimize the parameters viz., sorbent dosage and particle loading, and to study the interactive effects using response surface method (RSM). At the optimized conditions, experiments were performed at various organic loading rates by varying initial textile dye wastewater concentration and hydraulic retention time (HRT). The anaerobic biodegradation of textile dyeing wastewater in the MASBR was analyzed in terms of decolorization, COD reduction, biogas production, volatile fatty acids (VFA) at different organic loading rate (OLR) between 0.110 and 0.650 kgCOD/m3 d. A maximum decolorization of 94.8% and COD reduction of 97.1% were obtained in the MASBR. The novel sorbent utilized in the study was characterized using FTIR and SEM analysis.

63 citations

Journal ArticleDOI
TL;DR: By recognizing their numerous ecological, environmental, and biomedical roles, substantiated by inexpensive and more comprehensive investigations, earthworms will become more aware of their undiscovered beneficial properties.
Abstract: Earthworms have provided ancient cultures with food and sources of medicinal cures. Ayurveda, traditional Chinese medicine (TCM), and practices in Japan, Vietnam, and Korea have focused first on earthworms as sources of food. Gradually fostering an approach to potential beneficial healing properties, there are renewed efforts through bioprospecting and evidence-based research to understand by means of rigorous investigations the mechanisms of action whether earthworms are used as food and/or as sources of potential medicinal products. Focusing on earthworms grew by serendipity from an extensive analysis of the earthworm’s innate immune system. Their immune systems are replete with leukocytes and humoral products that exert credible health benefits. Their emerging functions with respect to evolution of innate immunity have long been superseded by their well-known ecological role in soil conservation. Earthworms as inexpensive, noncontroversial animal models (without ethical concerns) are not vectors of disease do not harbor parasites that threaten humans nor are they annoying pests. By recognizing their numerous ecological, environmental, and biomedical roles, substantiated by inexpensive and more comprehensive investigations, we will become more aware of their undiscovered beneficial properties.

63 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202326
2022119
2021673
2020693
2019576
2018507