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Institution

Annamalai University

EducationChidambaram, Tamil Nadu, India
About: Annamalai University is a education organization based out in Chidambaram, Tamil Nadu, India. It is known for research contribution in the topics: Lipid peroxidation & Antioxidant. The organization has 8098 authors who have published 10758 publications receiving 203872 citations.


Papers
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Journal ArticleDOI
TL;DR: Compared with nonanemic preschoolers, preschoolers with IDA displayed less social looking toward their mothers, moved close to their mothers more quickly, and were slower to display positive affect and touch novel toys for the first time.
Abstract: This study compared social looking and response to novelty in preschool-aged children (47-68 mo) with or without iron deficiency anemia (IDA). Iron status of the participants from a low-income community in New Delhi, India, was based on venous hemoglobin, mean corpuscular volume, and red cell distribution width. Children's social looking toward adults, affect, and wary or hesitant behavior in response to novelty were assessed in a semistructured paradigm during an in-home play observation. Affect and behavior were compared as a function of iron status: IDA (n = 74) vs. nonanemic (n = 164). Compared with nonanemic preschoolers, preschoolers with IDA displayed less social looking toward their mothers, moved close to their mothers more quickly, and were slower to display positive affect and touch novel toys for the first time. These results indicate that IDA in the preschool period has affective and behavioral effects similar to those reported for IDA in infancy.

107 citations

Journal ArticleDOI
TL;DR: CPC exhibited antioxidant and antiproliferative activity against human cancer cells through apoptosis; nuclear apoptosis induction was accompanied by G0/G1 phase arrest and DNA fragmentation, and CPC is a natural pigment with potential as an anticancer agent.

106 citations

Journal ArticleDOI
TL;DR: In this article, the dissolution rate and stability of a poorly water-soluble drug quercetin by complexation with cyclodextrin-based nanosponges were investigated.
Abstract: Quercetin is a flavonoid widely distributed in vegetables and fruits and exhibits strong antioxidant activity, but the poor solubility and stability of quercetin limit its function and application The purpose of this study was to enhance the dissolution rate and stability of a poorly water-soluble drug quercetin by complexation with cyclodextrin-based nanosponges Nanosponges are recently developed sponge-like structures and have the capacity to interact with small molecules in its matrix In this study, five types of nanosponges were purposely designed by varying the molar ratio of β-cyclodextrin and diphenyl carbonate Quercetin was loaded into nanosponges by freeze-drying method The particle sizes of plain and quercetin-loaded nanosponges are in between 40 and 100 nm with low polydispersity indices Zeta potential is sufficiently high to obtain a stable colloidal nanosuspension Fourier transformed infrared, Raman spectroscopy, differential scanning calorimetry, and X-ray powder diffraction studies confirmed the interaction of quercetin with nanosponges Particle sizes measured from TEM images were in agreement with DLS results The dissolution of the quercetin nanosponges was significantly higher compared with the pure drug The stability of encapsulated quercetin nanosponge was tracked in a simulated intestinal fluid A marked improvement in the photostability was also observed In addition, the antioxidant activity of the quercetin nanosponges was more effective than pure quercetin on DPPH scavenging, anti-superoxide formation, and superoxide anion scavenging These results signify that nanosponge formulations can be used as effective nanocarriers for the delivery of quercetin

106 citations

Journal ArticleDOI
TL;DR: The results show that pretreatment with lycopene offers protection against gamma-radiation induced cellular damage and can be developed as an effective radioprotector during radiotherapy.

105 citations

Journal ArticleDOI
TL;DR: A polysaccharide extracted from the leaf of Rhizophora apiculata was assessed in cell culture systems, for its activity against human and simian immunodeficiency viruses, and its properties may be advantageous should RAP be considered for further development.

105 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202326
2022119
2021673
2020693
2019576
2018507