Annamalai University

About: Annamalai University is a education organization based out in Chidambaram, Tamil Nadu, India. It is known for research contribution in the topics: Lipid peroxidation & Antioxidant. The organization has 8098 authors who have published 10758 publications receiving 203872 citations.

Nimbolide a limonoid from Azadirachta indica inhibits proliferation and induces apoptosis of human choriocarcinoma (BeWo) cells

Abstract: We investigated the cytotoxic effects of nimbolide, a limonoid present in leaves and flowers of the neem tree (Azadirachta indica) on human choriocarcinoma (BeWo) cells. Treatment with nimbolide resulted in dose- and time-dependent inhibition of growth of BeWo cells with IC50 values of 2.01 and 1.19 μM for 7 and 24 h respectively, accompanied by downregulation of proliferating cell nuclear antigen. Examination of nuclear morphology revealed fragmentation and condensation indicating apoptosis. Increase in the generation of reactive oxygen species (ROS) that was reversed by addition of reduced glutathione suggested ROS involvement in the cytotoxicity of nimbolide. A decrease in Bcl-2/Bax ratio with increased expression of Apaf-1 and caspase-3, and cleavage of poly(ADP-ribose) polymerase provide compelling evidence that nimbolide-induced apoptosis is mediated by the mitochondrial pathway. The results of the present study suggest that nimbolide has immense potential in cancer prevention and therapy based on its antiproliferative and apoptosis inducing effects.

Study of electrochemical machining characteristics of Al/SiCp composites

Abstract: Non-conventional machining is increasing in importance due to some of the specific advantages which can be exploited during machining operation. Electrochemical machining (ECM) appears to be a promising technique, since in many areas of application, it offers several special advantages including higher machining rate, better precision and control, and a wider range of materials that can be machined. The present work is, therefore, initiated to investigate the influence of some predominant electrochemical process parameters such as applied voltage, electrolyte concentration, electrolyte flow rate and tool feed rate on the metal removal rate (MRR), and surface roughness (Ra) to fulfill the effective utilization of electrochemical machining of LM25 Al/10%SiC composites produced through stir casting. The contour plots are generated to study the effect of process parameters as well as their interactions. The process parameters are optimized based on Response Surface Methodology (RSM).