Institution
Annamalai University
Education•Chidambaram, Tamil Nadu, India•
About: Annamalai University is a education organization based out in Chidambaram, Tamil Nadu, India. It is known for research contribution in the topics: Lipid peroxidation & Antioxidant. The organization has 8098 authors who have published 10758 publications receiving 203872 citations.
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TL;DR: It is indicated that d‐limonene has antioxidant potential in addition to its antidiabetic effect in experimental diabetes and thereby conferred protection against STZ‐induced diabetic rats.
Abstract: The aim of this study was to evaluate the protective effects of D-limonene on the levels of lipid peroxidation by-products and antioxidant defence systems in the plasma and tissues of normal and streptozotocin (STZ)-induced diabetes rats. The experimental diabetes was induced in rats by a single dose of STZ (40 mg/kg i.p.) injection, and treatment with D-limonene was continued for 45 days. After the treatment period, oxidative stress parameters such as lipid peroxidation by-products; enzymatic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase; non-enzymic antioxidants including reduced glutathione, Vitamins C and E were measured in the plasma and tissues of experimental rats. An increase in the levels of lipid peroxidation by-products and significant decrease in antioxidant enzymes were observed in untreated diabetic rats. Administration of D-limonene to diabetic rats for 45 days caused a significant reduction in the levels of lipid peroxidation by-products and an increase in the activities of antioxidant enzymes, when compared with the untreated diabetic group. There was no significant difference in normal treated groups, when compared with normal rats. Biochemical observations were substantiated with the help of histopathological examinations through its antioxidant properties and thereby conferred protection against STZ-induced diabetic rats. The result of this study indicates that D-limonene has antioxidant potential in addition to its antidiabetic effect in experimental diabetes.
95 citations
TL;DR: Artificial neural network model, based on multilayered partial recurrent back-propagation algorithm has been used for the prediction of percentage adsorption efficiency for the removal of Cu(II) ions from aqueous solutions by sawdust and is found to be very impressive.
94 citations
TL;DR: Results indicated that the anticancer activity of F2 could be related to its sulfate content, however, the antioxidant activities of F1–F3 were low at their tested concentrations.
94 citations
TL;DR: Oral supplementation of esculetin to diabetic rats for 45 days significantly brought back lipid peroxidation markers, enzymic and nonenzymic antioxidants to near normalcy, and histological observations evidenced that Esculetin effectively rescues the hepatocytes and kidney from hyperglycemia mediated oxidative damage without affecting its cellular function and structural integrity.
94 citations
TL;DR: AA is found to be potential bioactive compound to regulate the carbohydrate metabolism by modulating the key regulatory enzymes in diabetic rats and merit further research in this field.
94 citations
Authors
Showing all 8164 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Dinesh Mohan | 79 | 283 | 35775 |
| Sampath Parthasarathy | 77 | 268 | 34280 |
| Mandyam V. Srinivasan | 68 | 344 | 15572 |
| Leelavinothan Pari | 58 | 160 | 8374 |
| Venugopal P. Menon | 54 | 195 | 10111 |
| Kadarkarai Murugan | 54 | 286 | 9280 |
| V. Balasubramanian | 54 | 457 | 10951 |
| Marimuthu Govindarajan | 52 | 212 | 6738 |
| Annamalai Subramanian | 49 | 95 | 6021 |
| Meenakshisundaram Swaminathan | 48 | 239 | 8698 |
| Siddavaram Nagini | 47 | 185 | 7371 |
| Mohan K. Balasubramanian | 47 | 130 | 6238 |
| Subash C. B. Gopinath | 45 | 455 | 7855 |
| Sunil Sazawal | 44 | 111 | 9774 |
| Al. Ramanathan | 43 | 235 | 6132 |