Antelope Valley Hospital
Healthcare•Lancaster, California, United States•
About: Antelope Valley Hospital is a(n) healthcare organization based out in Lancaster, California, United States. It is known for research contribution in the topic(s): Head injury & Emergency department. The organization has 14 authors who have published 17 publication(s) receiving 233 citation(s).
Topics: Head injury, Emergency department, Stigma (botany), Upper gastrointestinal bleeding, Intensive care unit
TL;DR: The pilot study demonstrates that the ewe is an excellent model for uterine transplant research and with further studies; it is planned to demonstrate that a pregnancy can be achieved after a successful uterine transplants.
Abstract: Study Objective The purpose of this project is to develop a uterine transplant procedure in the sheep model that may be suitable for human uterine transplants. Design Pilot study (Canadian Task Force classification II-2). Setting University De La Salle Bogota, Colombia. Patients A total of 10 sexually matured sheep undergoing uterine allotransplantation. Interventions Uterine transplantation through a minilaparotomy incision with the application of a 900-500 modified Mobius retractor device. Measurements and Main Results The short-term effects of warm and cold tissue ischemia were quantified and uterine tissue reperfusion was analyzed after vascular reanastomosis. The ovine model was preferred since the anatomical landmarks and vascular anatomy are comparable to the human with the exception of a bicornuate uterus in the subprimate model. A modified surgical procedure was applied to our uterine allotransplanted sheep (n = 10) and tissue rejection was managed with cyclosporine therapy. A total abdominal hysterectomy without oophorectomy was performed and a cold ischemic time of 45 minutes was recorded. The uterine arteries and veins were reapproximated using a continuous end-to-end noninterlocking approach. Vascular patency and uterine tissue viability were assessed by histological studies. Complete tissue reperfusion of blood was achieved in our 10 animals within 30 seconds after vascular reanastomosis without evidence of arterial or venous thrombosis. At 6 months postuterine transplantation, hysterectomies were performed documenting viable uterine tissue and vascular patency in 6 out of the 10 uterine allotransplants. The site of uterine vessel reanastomosis was patent and histological studies indicated neovascularization with presence of smooth muscle and glandular endometrial tissue. Conclusion We have developed a modified procedure that has allowed us to perform successful uterine transplants in the sheep model. This is the first reported case in the literature documenting a successful procedure of uterine allotransplantation in the ewe. Our pilot study demonstrates that the ewe is an excellent model for uterine transplant research and with further studies; we plan to demonstrate that a pregnancy can be achieved after a successful uterine transplant.
01 Sep 2010-Neonatal network : NN
TL;DR: The mechanisms governing fluid distribution in the extracellular spaces are discussed, the various etiologies associated with NIHF are examined, and the pathogenesis of NIHF is described for each etiologic category.
Abstract: Nonimmune hydrops fetalis (NIHF) is a condition in which excess fluid has accumulated in the fetal interstitial spaces as a result of one or more nonimmune factors. A plethora of maternal, placental, and fetal disease processes have been associated with NIHF. Knowledge of the various etiologies of NIHF and how the disease process affects fluid homeostasis is important for planning patient care and counseling families of patients diagnosed with nonimmune hydrops fetalis. This article discusses the mechanisms governing fluid distribution in the extracellular spaces, examines the various etiologies associated with NIHF, and describes the pathogenesis of NIHF for each etiologic category.
TL;DR: This study studies a mother and daughter with an extremely rare constellation of signs and symptoms that supports the autosomal dominant inheritance of this syndrome, delineates the ophthalmic manifestations, and provides evidence that renal anomalies are part of the disorder.
Abstract: We studied a mother and daughter with an extremely rare constellation of signs and symptoms. One or both had absent lacrimal puncta, nasolacrimal duct obstruction, chronic dacryocystitis, dry eyes, and epiphora. Systemic findings included salivary gland hypo-secretion, dental hypoplasia and dysplasia, cup-shaped ears with hearing loss, and digital anomalies. These findings are consistent with those of the lacrimo-auriculo-dento-digital syndrome, a genetic disorder. Our study supports the autosomal dominant inheritance of this syndrome, delineates the ophthalmic manifestations, and provides evidence that renal anomalies are part of the disorder.
TL;DR: How radiographic images of the cervical spine can differentiate tumors, inflammation, recent or prior trauma, and the range of discal, arthritic, neural, and vascular cervical pathologies and, just as importantly, when they cannot is explained.
Abstract: This article provides an essential curriculum in cervical spine radiology. It discusses the uses of plain radiographs, MR imaging, computed tomography (CT), and CT myelography, in addition to the methodologies of discography, epidural injections under visualization, and facet and nerve root injections. It explains how radiographic images of the cervical spine can differentiate tumors, inflammation, recent or prior trauma, and the range of discal, arthritic, neural, and vascular cervical pathologies and, just as importantly, when they cannot.
TL;DR: POC US can be helpful in identifying and further delineating intramuscular abscesses and can subsequently lead to expedited and appropriate care in patients who present with extremity pain, but lack significant dermatologic changes.
Abstract: Background Pyomyositis is a bacterial infection of skeletal muscle that often results in deep intramuscular abscesses. The absence of external dermatologic manifestations in the early stages of pyomyositis makes this a challenging diagnosis. In addition, physical examination findings can be difficult to distinguish from more common processes, such as soft-tissue cellulitis. Clinicians can fail to diagnose this serious disease in a timely manner, resulting in delayed treatment and potential clinical deterioration from sepsis. Although advanced imaging modalities, such as computed tomography (CT) and magnetic resonance imaging (MRI) provide excellent detail, ultrasound (US) can also be used to detect this disease. US can be performed expeditiously at the bedside and is less expensive than CT or MRI. It allows the clinician to examine the deeper tissue planes of muscle, in which purulent fluid collections will develop as pyomyositis advances. Case Report Three patients presenting with leg pain were evaluated with point-of-care (POC) US and diagnosed with pyomyositis. The early diagnosis of this condition prompted rapid treatment with administration of appropriate antibiotics and involvement of orthopedic surgery. Aspiration of fluid allowed for detailed fluid analysis and bacterial cultures. Additional diagnostic imaging was performed, confirming the initial US diagnosis. Why Should an Emergency Physician Be Aware of This? POC US can be helpful in identifying and further delineating intramuscular abscesses and can subsequently lead to expedited and appropriate care in patients who present with extremity pain, but lack significant dermatologic changes.
Showing all 14 results
|Tram B. Cat||2||2||13|
|Monica P. Kumar||2||2||32|
|Pravin K. Krishna||1||1||4|
|Andrew L Deutsch||1||1||23|
|Maryann M Deguzman||1||1||12|
|Edwin R. Ramirez||1||1||59|
|Andrea L Randenberg||1||1||26|
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