Applied Biosystems

About: Applied Biosystems is a based out in . It is known for research contribution in the topics: Mass spectrometry & Capillary electrophoresis. The organization has 1521 authors who have published 1579 publications receiving 285423 citations.

Capillary detector cell having imaging elements positioned to optimize sensitivity

Abstract: A detector cell, having a capillary entrance elbow through which a beam of exposing light can be directed into the bore of a central leg of the detector cell capillary. Ray traces, to determine the effect of the entrance elbow on the beam of exposing light are used to optimize performance of this detector cell. Back ray tracing is implemented to illustrate an optimized embodiment. Forward ray tracing is also illustrated and can be used to determine system performance for a range or choices of a single parameter or for concurrent ranges of choices of a subset of the parameters of the beam of exposing light.

Fluorogenic enzyme activity assay methods and compositions using fragmentable linkers

Abstract: Substrate compound-containing micelles and various compositions, kits and methods for their preparation and use are provided.

Methods and kits for methylation detection

Abstract: Ligation-based methods and kits are disclosed for determining the degree of methylation of one or more target nucleotides. In certain embodiments, the methylation status of one or more target nucleotides is determined by generating misligation products. In certain embodiments, at least one target nucleotide is amplified prior to the ligation reaction. In certain embodiments, at least one ligation product, at least one ligation product surrogate, at least one misligation product, at least one misligation product surrogate, or combinations thereof are amplified. In certain embodiments, one or more ligation probes comprise at least one nucleotide analog, at least one Modification, at least one mismatched nucleotide, or combinations thereof.

Automated seal applicator

Abstract: An automated seal applicator for applying a sealing cover to a microplate. The microplate can comprise a plurality of wells for receiving an assay. The automated seal applicator can comprise a housing and a removable sealing cover cassette containing a sealing cover roll. The sealing cover roll can comprise an elongated carrier liner and a plurality of individual sealing covers releasably carried on the elongated carrier liner. The sealing cover cassette can be selectively engagable with the housing. A sealing cover drive system can engage the sealing cover roll and maintain a predetermined alignment of each of the plurality of individual sealing covers relative to the microplate.