Applied Science Private University

About: Applied Science Private University is a education organization based out in Amman, Jordan. It is known for research contribution in the topics: Population & Catalysis. The organization has 4124 authors who have published 5299 publications receiving 116167 citations.

Heuristics Evaluation Strategy for Mobile Game-Based Learning

Abstract: Evaluation of learning media is necessary for determining the effectiveness of the produced media. When evaluating mobile game-based learning (mGBL), conventional usability heuristics evaluations lack comprehension and difficult to be directly implemented. Therefore, heuristics evaluation strategy is proposed to evaluate specifically for mGBL. The strategy consists of four components: Game Usability, Mobility, Game Play, and Learning Content. Each of the components represents the issues to be considered and evaluated for mGBL. Additionally, in this study, a prototype of mGBL was developed and evaluated by utilizing the proposed strategy. The results indicate that the strategy is useful and potential to be implemented for similar mGBL applications.

Pharmacotherapy for Fragile X Syndrome: Progress to Date.

Abstract: To date, no drug is approved for the treatment of Fragile X Syndrome (FXS) although many drugs are used to manage challenging behaviors from a symptomatic perspective in this population. While our understanding of FXS pathophysiology is expanding, efforts to devise targeted FXS-specific treatments have had limited success in placebo-controlled trials. Compounds aimed at rectifying excessive glutamate and deficient gamma-aminobutyric acid (GABA) neurotransmission, as well as other signaling pathways known to be affected by Fragile X Mental Retardation Protein (FMRP) are under various phases of development in FXS. With the failure of several metabotropic glutamate receptor subtype 5 (mGlur5) selective antagonists under clinical investigation, no clear single treatment appears to be greatly effective. These recent challenges call into question various aspects of clinical study design in FXS. More objective outcome measures are under development and validation. Future trials will likely be aimed at correcting multiple pathways known to be disrupted by the loss of FMRP. This review offers a brief summary of the prevalence, phenotypic characteristics, genetic causes and molecular functions of FMRP in the brain (as these have been extensively reviewed elsewhere), discusses the most recent finding in FXS drug development, and summarizes FXS trials utilizing symptomatic treatment.

Recrystallization behavior and tensile properties of laser metal deposited Inconel 718 upon in-situ ultrasonic impact peening and heat treatment

Abstract: Due to the lack of mechanical compaction, the overall properties of metal parts produced by laser-based additive manufacturing are lower than those of traditional wrought parts. This thus limits the potential of additive manufacturing (AM) techniques in the producing critical structural components. The integration of in-situ ultrasonic impact peening (UIP) with metal AM processes has demonstrated promising results in improving the mechanical properties. In this work, the influence of in-situ layerwise UIP on the recrystallization behavior and tensile properties are investigated for Inconel 718 parts fabricated by the novel hybrid manufacturing process combining laser metal deposition (LMD) and UIP. Also, post heat treatments with different solid solution treatment (ST) temperatures are carried out to investigate the role of heat treatment in material recrystallization, as well as the related mechanical properties. The results demonstrate that a proper combination of in situ UIP and heat treatment significantly facilitates recrystallization refinement and enhances the mechanical properties. Under the optimal 1180 °C ST + age condition, the part manufactured by LMD + UIP hybrid process shows a yield strength (YS) of 977 MPa, ultimate tensile strength (UTS) of 1240 MPa, and tensile modulus of 209 GPa, representing the increases of 28%, 15%, and 67%, respectively, compared with LMD parts made without in-situ UIP.