Institution
Applied Science Private University
Education•Amman, Jordan•
About: Applied Science Private University is a education organization based out in Amman, Jordan. It is known for research contribution in the topics: Population & Catalysis. The organization has 4124 authors who have published 5299 publications receiving 116167 citations.
Papers published on a yearly basis
Papers
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TL;DR: KMP protected against IR injury by attenuating inflammation and apoptosis through the modulation of MAPK pathway by maintaining cardiac function, normalizing oxidative stress, and preserving morphological alterations.
Abstract: Kaempferol (KMP), a dietary flavonoid, has antioxidant, anti-inflammatory, and antiapoptotic effects. Hence, we investigated the effect of KMP in ischemia-reperfusion (IR) model of myocardial injury in rats. We studied male albino Wistar rats that were divided into sham, IR-control, KMP-20 + IR, and KMP 20 per se groups. KMP (20 mg/kg; i.p.) was administered daily to rats for the period of 15 days, and, on the 15th day, ischemia was produced by one-stage ligation of left anterior descending coronary artery for 45 min followed by reperfusion for 60 min. After completion of surgery, rats were sacrificed; heart was removed and processed for biochemical, morphological, and molecular studies. KMP pretreatment significantly ameliorated IR injury by maintaining cardiac function, normalizing oxidative stress, and preserving morphological alterations. Furthermore, there was a decrease in the level of inflammatory markers (TNF-α, IL-6, and NFκB), inhibition of active JNK and p38 proteins, and activation of ERK1/ERK2, a prosurvival kinase. Additionally, it also attenuated apoptosis by reducing the expression of proapoptotic proteins (Bax and Caspase-3), TUNEL positive cells, and increased level of antiapoptotic proteins (Bcl-2). In conclusion, KMP protected against IR injury by attenuating inflammation and apoptosis through the modulation of MAPK pathway.
78 citations
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TL;DR: T-PA@iRNP presents therapeutic potential through synergistic effect of thrombolysis and antioxidant effects for preventing and treating ischemia-reperfusion injury and remarkably extended the in vivo half-life of t-PA in systemic circulation.
78 citations
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TL;DR: The hot deformation behavior and microstructural evolution of an Al-Zn-Mg-Cu (7150) alloy was studied during hot compression at various temperatures and strain rates, revealing that the dynamic recovery is the sole softening mechanism at temperatures of 300 to 400 °C with various strain rates.
Abstract: The hot deformation behavior and microstructural evolution of an Al-Zn-Mg-Cu (7150) alloy was studied during hot compression at various temperatures (300 to 450 °C) and strain rates (0.001 to 10 s−1). A decline ratio map of flow stresses was proposed and divided into five deformation domains, in which the flow stress behavior was correlated with different microstructures and dynamic softening mechanisms. The results reveal that the dynamic recovery is the sole softening mechanism at temperatures of 300 to 400 °C with various strain rates and at temperatures of 400 to 450 °C with strain rates between 1 and 10 s−1. The level of dynamic recovery increases with increasing temperature and with decreasing strain rate. At the high deformation temperature of 450 °C with strain rates of 0.001 to 0.1 s−1, a partially recrystallized microstructure was observed, and the dynamic recrystallization (DRX) provided an alternative softening mechanism. Two kinds of DRX might operate at the high temperature, in which discontinuous dynamic recrystallization was involved at higher strain rates and continuous dynamic recrystallization was implied at lower strain rates.
78 citations
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TL;DR: The combination of TQ and RES against breast cancer in mice can work synergistically and the anticancer effect of this combination is mediated by apoptosis induction, angiogenesis inhibition and immune modulation.
78 citations
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TL;DR: In this paper, an Octadecylamine-modified graphene-oxide (OMGO) polybutadiene nanocomposites with different OMGO loadings were prepared by solution mixing, and the dispersion of OMGO in chloroform was greatly improved compared to GO.
78 citations
Authors
Showing all 4150 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hua Zhang | 163 | 1503 | 116769 |
Menachem Elimelech | 157 | 547 | 95285 |
Yu Huang | 136 | 1492 | 89209 |
Dmitri Golberg | 129 | 1024 | 61788 |
Andrea Carlo Marini | 123 | 1236 | 72959 |
Dionysios D. Dionysiou | 116 | 675 | 48449 |
Liyuan Han | 114 | 766 | 65277 |
Shunichi Fukuzumi | 111 | 1256 | 52764 |
John A. Stankovic | 109 | 559 | 51329 |
Judea Pearl | 107 | 512 | 83978 |
Feng Wang | 107 | 1136 | 64644 |
O. C. Zienkiewicz | 107 | 455 | 71204 |
Jeffrey I. Zink | 99 | 509 | 42667 |
Kazuhiro Hono | 98 | 878 | 33534 |
Robert W. Boyd | 98 | 1161 | 37321 |