Atlantic Health System

About: Atlantic Health System is a healthcare organization based out in Morristown, New Jersey, United States. It is known for research contribution in the topics: Catheter ablation & Antiarrhythmic agent. The organization has 277 authors who have published 299 publications receiving 6594 citations.

Antiangiogenic therapy using bevacizumab in recurrent high-grade glioma: impact on local control and patient survival.

Abstract: Object Antiangiogenic agents have recently shown impressive radiological responses in high-grade glioma. However, it is not clear if the responses are related to vascular changes or due to antitumoral effects. The authors report the mature results of a clinical study of bevacizumab-based treatment of recurrent high-grade gliomas. Methods Sixty-one patients with recurrent high-grade gliomas received treatment with bevacizumab at 10 mg/ kg every 2 weeks for 4 doses in an 8-week cycle along with either irinotecan or carboplatin. The choice of concomitant chemotherapeutic agent was based on the number of recurrences and prior chemotherapy. Results At a median follow-up of 7.5 months (range 1–19 months), 50 (82%) of 61 patients relapsed and 42 patients (70%) died of the disease. The median number of administered bevacizumab cycles was 2 (range 1–7 cycles). The median progression-free survival (PFS) and overall survival (OS) were 5 (95% confidence interval [CI] 2.3–7.7) and 9 (95% CI 7.6–10.4) months, respectiv...

Chronic childhood constipation is associated with impaired quality of life: a case-controlled study.

Abstract: Objective: The objective of this study was to investigate the effect of chronic constipation on children's quality of life Methods: From October 2002 to November 2003, 224 children (140 male, 84 female, aged 106 ± 29 years) and 224 parents were evaluated by a health related quality of life tool during initial outpatient consultation Children with constipation (n = 80) were compared with controls with inflammatory bowel disease (n = 42), controls with gastroesophageal reflux disease (n = 56), and with healthy children (n = 46) Results: Children with constipation had lower quality of life scores than did those with inflammatory bowel disease (70 versus 84; P < 005), gastroesophageal reflux disease (70 versus 80; P < 005), and healthy children (70 versus 88; P < 005) Children with constipation reported lower physical scores than did inflammatory bowel disease patients (75 versus 85; P < 002), gastroesophageal reflux disease patients (75 versus 85; P < 005), or healthy children (75 versus 87; P < 005) Parents of children with constipation reported lower scores than did their children (61 versus 70; P < 005) Children with constipation had longer duration of symptoms than did the controls with inflammatory bowel disease and gastroesophageal reflux disease (438 months versus 142 months; P < 0001) Prolonged duration of symptoms fur children with constipation correlated with lower parent-reported scores (P < 0002) Conclusions: At initial evaluation, children with constipation have a lower quality of life than do children with inflammatory bowel disease or gastroesophageal reflux disease Self-reported lower scores may be a reflection of impaired physical ability Parental perceptions of low quality of life are probably impacted by the duration of their child's symptoms and by family members with similar complaints Practitioners should be aware of the high level of parental concern and the relatively low self-reported and parent-reported quality of life in children with chronic constipation as they plan therapy