Institution
Atlantic Health System
Healthcare•Morristown, New Jersey, United States•
About: Atlantic Health System is a healthcare organization based out in Morristown, New Jersey, United States. It is known for research contribution in the topics: Health care & Medicine. The organization has 277 authors who have published 299 publications receiving 6594 citations.
Papers published on a yearly basis
Papers
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TL;DR: More research is needed to determine the role of prophylactic salpingectomy with delayed oophorectomy, optimal timing of completion oophoresis, and the risks and benefits compared with up-front risk-reducing salpingo-oophoreCTomy.
7 citations
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TL;DR: A positive perception about participation in research is not stratified by successful completion of a PCT, and investigators and institutional review boards should encourage them that if properly designed and conducted, pediatric PCTs can result in a positive experience for parents.
Abstract: Background and Objectives: Investigators may have concerns that parents will not allow their children to participate in placebo-controlled trials (PCTs). The aim of the present study was to identify potential differences between parental perceptions in families who successfully completed (CO) a clinical trial compared with those who were noncompleters (NC). Patients and Methods: Parents of both CO and NC children enrolled in pediatric gastrointestinal studies performed in the previous year were eligible. NC were defined as those who were screen failures or treatment nonresponders or had adverse events. One hundred seven parents were identified and mailed a 26-item questionnaire eliciting perceptions regarding participation in research. Questionnaires were sent 6 months after participation in research ended. Results: Seventy-eight (69%) parents returned the survey. Characteristics included maternal responders (98%), English as primary language (97%), and education beyond high school (85%). Five parents (4.7%) had children involved in previous research trials. There were no significant differences in responses found between CO (n = 49; 63%) and NC (n = 29; 37%) in regard to importance of research, perceptions of risk to child, benefits to child, and more attention in the study. Statistical significance was approached in regard to the comfort with the research team, with a greater portion of CO stating that the researcher put the parent at ease and the NC feeling less positive about the interaction (P=0.05). Conclusions: A positive perception about participation in research is not stratified by successful completion of a PCT. These results should encourage investigators and institutional review boards that if properly designed and conducted, pediatric PCTs can result in a positive experience for parents.
7 citations
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TL;DR: In this paper, a hybrid therapy utilizing catheter RA maze procedures with overdrive atrial pacing and antiarrhythmic drugs can be performed safely and can reestablish rhythm control in selected patients with refractory persistent or permanent atrial fibrillation.
Abstract: Right atrial (RA) maze procedures using linear catheter ablation have had limited efficacy in paroxysmal atrial fibrillation (AF). We hypothesized that “hybrid” therapy using overdrive atrial pacing and antiarrhythmic drugs can improve efficacy of catheter RA maze and expand its role to persistent or permanent AF. Catheter RA maze procedures were performed in 26 patients with persistent or permanent AF refractory to 4.5 ± 2.1 antiarrhythmic drugs. Overdrive dual-site RA pacing (21 patients) or high RA pacing (5 patients) was continued (n = 11) or instituted periablation (n = 15). All patients continued receiving previously ineffective antiarrhythmic drugs. Freedom from permanent AF (rhythm control), symptomatic and/or asymptomatic AF recurrences, the safety of hybrid therapy, and overall survival were assessed. There was no procedure-related mortality or stroke. Rhythm control was achieved in 24 patients (92%) within 3 months. During long-term follow-up (6 to 49 months, mean 17 ± 10), rhythm control was maintained in 20 patients (77%). Nine patients (35%) had no AF recurrences, whereas 11 patients maintained rhythm control with infrequent AF recurrences. Device datalogs at the study cut-off point demonstrated no AF events in 6 patients, nonsustained atrial tachycardia in 2 patients, and brief asymptomatic paroxysmal AF in 12 patients. Actuarial patient survival was 95% at 1 year and 74% at 2 years of follow-up. Thus, hybrid therapy utilizing catheter RA maze procedures with overdrive atrial pacing and antiarrhythmic drugs can be performed safely and can reestablish rhythm control in selected patients with refractory persistent or permanent AF.
7 citations
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7 citations
Authors
Showing all 279 results
Name | H-index | Papers | Citations |
---|---|---|---|
Kurt A. Jaeckle | 57 | 169 | 14597 |
Donald E. Casey | 56 | 102 | 62844 |
Sanjeev Saksena | 44 | 169 | 6463 |
John J. Halperin | 42 | 145 | 9806 |
Linda D. Gillam | 39 | 102 | 9249 |
Missak Haigentz | 39 | 129 | 4217 |
Ian J. Griffin | 35 | 107 | 3998 |
Philip T. Levy | 30 | 106 | 6823 |
Patrick J. Culligan | 29 | 72 | 2962 |
Joel R. Rosh | 27 | 92 | 5189 |
Michael L. Gruber | 24 | 45 | 4877 |
Linda D. Gillam | 20 | 61 | 1895 |
Eric D. Whitman | 19 | 48 | 2576 |
Elizabeth A. Eckman | 19 | 33 | 3743 |
Brian M. Slomovitz | 16 | 75 | 1595 |