Atlantic Health System

About: Atlantic Health System is a healthcare organization based out in Morristown, New Jersey, United States. It is known for research contribution in the topics: Catheter ablation & Antiarrhythmic agent. The organization has 277 authors who have published 299 publications receiving 6594 citations.

Sports-Related Traumatic Brain Injury and Concussion

Abstract: Sports-related concussions (SRC) continue to be a major area of concern in athletes who participate in collision and contact sports. There is growing recognition that concussion from sport is a public health priority, with many states and sport-governing bodies changing rules in an attempt to prevent and/or reduce the incidence of concussion from sport-related impact.

Complementary, Integrative, and Holistic Medicine: Integrative Approaches to Pediatric Irritable Bowel Syndrome

Abstract: 1. Alycia Leiby, MD*,† 2. Minal Vazirani, MD‡,¶ 1. *Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Goryeb Children’s Hospital, Atlantic Health System, Morristown, NJ. 2. †Department of Pediatrics, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA. 3. ‡Siegler Center for Integrative Medicine, Barnabas Health ACC Barnabas Health System, Livingston, NJ. 4. ¶Rutgers – New Jersey Medical School, Newark, NJ. Irritable bowel syndrome (IBS) occurs commonly in pediatrics, with the prevalence estimated at 6% to 14%. (1)(2) The Rome criteria define pediatric IBS as abdominal pain that improves with defecation and/or onset associated with a change in frequency or form of stool. (3) In addition, no evidence of an inflammatory, anatomic, metabolic, or neoplastic process explains the symptoms. The cause of IBS is attributed to a combination of factors, including an altered gut microbiome, low-grade mucosal inflammation, visceral hypersensitivity, abnormal motility, psychosocial stressors, and genetic predisposition. (4) Recognition of these factors serves as the foundation for the biopsychosocial approach to treating pediatric IBS. A successful treatment plan starts with a strong patient-parent-physician relationship in which the child’s pain is validated and the physician compassionately approaches the distress that IBS can cause. Multiple studies have shown that children with IBS have a lower quality of life (QOL) that is comparable to that seen with nonfunctional gastrointestinal conditions. (2)(5) Conventional treatment includes education and reassurance, cognitive behavioral therapy (CBT) for some patients, and consideration of antispasmodic or antidepressant medications. In practice, the lack of strong evidence, potential for adverse effects, and parental concern limit the utility of conventional pharmacologic options. Complementary and alternative medicine (CAM) use in pediatric gastroenterology is common and higher in patients with IBS than nonfunctional gastrointestinal conditions. (6) This article reviews the evidence for CAM therapy in IBS based on adult and pediatric data available in the English language. The World Health Organization defines probiotics as “live micro-organisms which, when administered …

Human Papilloma Virus (HPV) Infection and Non-Cervical Oncogenic DiseaseStates

Abstract: Human papillomavirus (HPV) infection is causative for cervical cancer and has been implicated in cancers at other sites. We review the English language literature in regard to the epidemiology of HPV infection as a risk for non-cervical cancer with a focus on the molecular evidence to support HPV having an etiologic role at each anatomic site. HPV DNA is detected in and/or serology provides evidence that HPV is associated with 35-50% of penile cancers, 80-95% of anal cancers, and ~35% of oropharyngeal cancers. HPV has also been implicated for cancer of the larynx, esophagus, lung, and urinary bladder with varying levels of linkage. Molecular studies at the respective anatomic sites provide evidence of HPV integration, E6 and E7 oncogene expression coupled with tumor suppressor down-regulation consistent with a role in the pathogenesis of tumor formation. HPV-associated cancer may represent a distinct disease entity relative to non HPV-associated cancers based upon natural history and outcome studies. Thus, the disease burden of HPV associated non-cervical cancers may be significant and justifies a comprehensive investigation of the utility of global prophylactic vaccination strategies.