Atlantic Health System

About: Atlantic Health System is a healthcare organization based out in Morristown, New Jersey, United States. It is known for research contribution in the topics: Health care & Medicine. The organization has 277 authors who have published 299 publications receiving 6594 citations.

Low-Dose Alteplase Infusion for the Treatment of Mechanical Aortic Valve Thrombosis: A Spotlight on the Importance of Medication Adherence.

Abstract: A rare, yet serious, complication of mechanical heart valves is symptomatic obstructive prosthetic valve thrombosis. The risk of valve thrombosis is magnified in patients who are nonadherent to prescribed anticoagulation. In this case report, we describe a 48-year-old male patient with a history of mechanical aortic valve replacement surgery, who stopped taking prescribed warfarin therapy 2 years before presentation and subsequently developed acute decompensated heart failure secondary to valvular dysfunction. Low-dose alteplase therapy was administered successfully with no bleeding complications and a complete return of valvular function.

Complementary, Integrative, and Holistic Medicine: Integrative Approaches to Pediatric Ulcerative Colitis

Abstract: 1. Alycia Leiby, MD* 2. Minal Vazirani, MD† 1. *Pediatric Gastroenterology and Nutrition, Goryeb Children's Hospital/Atlantic Health System, Morristown, NJ, and Department of Pediatrics, Mount Sinai School of Medicine, New York, NY. 2. †Integrative Medicine, Barnabas Health Ambulatory Care Center, Siegler Center for Integrative Medicine, Livingston, NJ. * Abbreviations: IBD: : inflammatory bowel disease UC: : ulcerative colitis 5-ASA: : 5-aminosalicylate CAM: : complementary and alternative medicine QoL: : quality of life ECN: : E Coli Nissle Twenty-five percent of inflammatory bowel disease (IBD) occurs in childhood, with 2 of 100,000 children age 1 to 17 years diagnosed as having ulcerative colitis (UC) in North America. (1) In a genetically predisposed individual, environmental factors lead to a dysregulated adaptive immune response to luminal commensal bacterial antigens, resulting in IBD. Although diet, infections, medications, and lack of breastfeeding have been implicated, further research is needed to elucidate the complex environmental and genetic interaction producing IBD. (2)(3)(4) Pediatric UC is often more extensive at initial presentation, with a 20% colectomy rate at 1 year in severe disease. (5) The risk of colorectal cancer, a potential long-term complication, is increased in those with a longer duration and earlier age of disease onset and greater extent of inflammation. (6) Conventional treatment of UC includes the use of corticosteroids to induce remission in moderate to severe disease and topical 5-aminosalicylate (5-ASA) as maintenance therapy. Recent prospective data confirmed the steroid-sparing effects of maintenance therapy with the immune-modulating thiopurine drugs 6-mercaptopurine and azathioprine in moderate to severe disease unresponsive to 5-ASA agents. (7) In children in whom conventional therapy fails, infliximab, a monoclonal antibody directed against tumor necrosis factor α, has been effective. (8) Despite evidence of benefit, the risk of infection and malignancy affect acceptance of administering these immune-modifying agents. The incidence of complementary and alternative medicine (CAM) use in pediatric IBD patients ranges from 40% to 70%. (9)(10)(11)(12) The common reason for using CAM is concern about adverse effects and the lack of efficacy of conventional therapies. Use of CAM was increased, particularly in patients with worse quality of life (QoL). (11)(13) This …