Atomic Energy of Canada Limited

About: Atomic Energy of Canada Limited is a company organization based out in Ottawa, Ontario, Canada. It is known for research contribution in the topics: Neutron & Zirconium alloy. The organization has 4845 authors who have published 4826 publications receiving 102951 citations.

Upper dose thresholds for radiation-induced adaptive response against cancer in high-dose-exposed, cancer-prone, radiation-sensitive Trp53 heterozygous mice.

Abstract: Mitchel, R. E. J., Jackson, J. S. and Carlisle, S. M. Upper Dose Thresholds for Radiation-Induced Adaptive Response against Cancer in High-Dose-Exposed, Cancer-Prone, Radiation-Sensitive Trp53 Heterozygous Mice. Radiat. Res. 162, 20–30 (2004). Trp53 heterozygous mice are radiation-sensitive and cancer-prone. Groups of 7–8-week-old female Trp53 heterozygous mice were exposed to 4 Gy of 60Co γ radiation at high (0.5 Gy/min) or low (0.5 mGy/min) dose rate. Other groups received 10 or 100 mGy at low dose rate 24 h prior to the 4-Gy dose. Tumor frequency and latency were measured over the animals' life span. Exposure to 10 mGy prior to 4 Gy resulted in a small (∼5%) but significant life-span regain and increased latency (∼9%) for all malignant tumors taken together, but 100 mGy further reduced life span slightly (∼7%). Latency responses were tumor type-specific. The prior 10-mGy exposure resulted in a small (∼7%) regain in latency for lymphomas but no change in latency for spinal osteosarcomas. Increa...

Vented Explosion of Hydrogen-Air Mixtures in a Large Volume

Abstract: Combustion experiments were carried out in a 2.3-m diameter spherical vessel with venting to the atmosphere over a hydrogen concentration range of6 to 20% by volume. Three vent sizes (15 em, 25 cm and 45 em) and three igniter locations (near-vent, centre and far-vent) were employed. The vents were initially covered with cardboard or aluminum foil that ruptured between I and 10 kPa. It was found that venting was effective in reducing the peak pressure at low hydrogen concentrations and for large vent areas for which the combustion times were much longer than the characteristic vent times. In all cases, central ignition led to the highest peak pressures and shortest combustion times, and near-vent ignition resulted in the lowest peak pressures and longest combustion times. Instabilities and turbulence caused by the vent opening resulted in enhanced burning rates. A simple one-dimensional model produced results in reasonable agreement with the experimental pressure transients when two burning rates (a lamina...