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Institution

Atomic Energy of Canada Limited

CompanyOttawa, Ontario, Canada
About: Atomic Energy of Canada Limited is a company organization based out in Ottawa, Ontario, Canada. It is known for research contribution in the topics: Zirconium alloy & Neutron. The organization has 4845 authors who have published 4826 publications receiving 102951 citations.


Papers
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01 Feb 1985
TL;DR: In this paper, a feasibility study shows that the key to reliable and cost-effective automatic reading of drawings is detailed planning of an operator-assisted system, and that this is the case for most drawings.
Abstract: A Canadian feasibility study shows that the key to reliable and cost-effective automatic reading of drawings is detailed planning of an operator-assisted system.

54 citations

Journal ArticleDOI
TL;DR: In this article, a temperature-time-transformation (TTT) diagram was developed for the β-phase in Zr-2.5Nb pressure tubes, and the results showed that the morphology and/or physical state of the β phase has a significant effect on the transformation behaviour compared with a bulk Zr−20-wt%Nb alloy.

54 citations

Book ChapterDOI
01 Jan 1977
TL;DR: It is led to conclude that DNA damage can lead to congenital malformations; thus, enzymatic DNA repair processes play a vital role in normal neonatal development.
Abstract: A unique feature of ataxia telangiectasia (AT), a hereditary multisystem disease, is extreme sensitivity to ionizing radiation, observed both clinically and in cell culture. Hence, we have measured the DNA repair capabilities of ten diploid fibroblast strains derived from unrelated AT donors, following anoxic 60Co γ-irradiation. Compared to two control strains, six of the ten mutant strains are markedly deficient in γ-induced repair replication. Two defective strains were defined further. While capable of rejoining single-strand breaks normally, both are impaired in the initial incision step in excision repair of base defects, assayed as γ-modified sites sensitive to a Micrococcus luteus endonuclease activity. Cell fusion studies assign three repair-deficient strains to two complementation groups; this result, coupled with a normal repair-replication ability in four of the ten AT strains, indicates genetic heterogeneity in the disease. AT strains appear otherwise normal, including their ability to repair UV damage. Aside from providing molecular insight into this complex disorder, our findings characterize AT as a γ-ray analogue of the UV-sensitive skin disease, xeroderma pigmentosum. Moreover, since AT patients are cancer-prone, faulty DNA repair is implicated in neoplastic transformation. Finally, given that (i) impaired embryonic differentiation best explains the clinical features of AT and (ii) defective DNA repair is of etiological relevance, we are led to conclude that DNA damage can lead to congenital malformations; thus, enzymatic DNA repair processes play a vital role in normal neonatal development.

54 citations

Journal ArticleDOI
TL;DR: The exogenous enzyme shortens the delay in recovery of the white blood cells, particularly after x-ray doses of 550 and 675 rad, and the earlier hematological recovery is attributable to the known radioprotective effect of the enzyme on bone marrow stem cells.

53 citations


Authors

Showing all 4845 results

NameH-indexPapersCitations
Henry P. Schwarcz7835120863
Jonathan N. Glickman7217224025
Andrej Atrens6941721741
See Leang Chin6746017181
Purnendu K. Dasgupta6250616779
John Katsaras552209263
Jing-Li Luo5543610963
Charles Gale5333110903
Sanjoy Banerjee522298880
Yoshio Takahashi504039801
Peter Sigmund4922011795
Michael P. Païdoussis461658825
Wei-Kan Chu464458616
A. G. W. Cameron4512310111
Erland M. Schulson442456966
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20221
20213
20205
20194
20185
20178