Institution
Augsburg College
Education•Minneapolis, Minnesota, United States•
About: Augsburg College is a education organization based out in Minneapolis, Minnesota, United States. It is known for research contribution in the topics: Population & Superconductivity. The organization has 10735 authors who have published 16986 publications receiving 295329 citations.
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the authors describe differences between moderator and mediator effects, and provide non-technical descriptions of how to examine each type of effect, including study design, analysis, and interpretation of results.
Abstract: The goals of this article are to (a) describe differences between moderator and mediator effects; (b) provide nontechnical descriptions of how to examine each type of effect, including study design, analysis, and interpretation of results; (c) demonstrate how to analyze each type of effect; and (d) provide suggestions for further reading. The authors focus on the use of multiple regression because it is an accessible data-analytic technique contained in major statistical packages. When appropriate, they also note limitations of using regression to detect moderator and mediator effects and describe alternative procedures, particularly structural equation modeling. Finally, to illustrate areas of confusion in counseling psychology research, they review research testing moderation and mediation that was published in the Journal of Counseling Psychology during 2001.
4,012 citations
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TL;DR: In this paper, the main emphasis is put on directed transport in so-called Brownian motors (ratchets), i.e. a dissipative dynamics in the presence of thermal noise and some prototypical perturbation that drives the system out of equilibrium without introducing a priori an obvious bias into one or the other direction of motion.
2,098 citations
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McGill University1, German Cancer Research Center2, Montreal Children's Hospital3, National Research Council4, Russian Academy5, Semmelweis University6, University of Debrecen7, University of Tübingen8, Boston Children's Hospital9, Augsburg College10, University of Würzburg11, Martin Luther University of Halle-Wittenberg12, Heidelberg University13, University of Toronto14, University of Düsseldorf15, University of Cambridge16, University Hospital Heidelberg17
TL;DR: The presence of H3F3A/ATRX-DAXX/TP53 mutations was strongly associated with alternative lengthening of telomeres and specific gene expression profiles, suggesting that defects of the chromatin architecture underlie paediatric and young adult GBM pathogenesis.
Abstract: Glioblastoma multiforme (GBM) is a lethal brain tumour in adults and children. However, DNA copy number and gene expression signatures indicate differences between adult and paediatric cases. To explore the genetic events underlying this distinction, we sequenced the exomes of 48 paediatric GBM samples. Somatic mutations in the H3.3-ATRX-DAXX chromatin remodelling pathway were identified in 44% of tumours (21/48). Recurrent mutations in H3F3A, which encodes the replication-independent histone 3 variant H3.3, were observed in 31% of tumours, and led to amino acid substitutions at two critical positions within the histone tail (K27M, G34R/G34V) involved in key regulatory post-translational modifications. Mutations in ATRX (α-thalassaemia/mental retardation syndrome X-linked) and DAXX (death-domain associated protein), encoding two subunits of a chromatin remodelling complex required for H3.3 incorporation at pericentric heterochromatin and telomeres, were identified in 31% of samples overall, and in 100% of tumours harbouring a G34R or G34V H3.3 mutation. Somatic TP53 mutations were identified in 54% of all cases, and in 86% of samples with H3F3A and/or ATRX mutations. Screening of a large cohort of gliomas of various grades and histologies (n = 784) showed H3F3A mutations to be specific to GBM and highly prevalent in children and young adults. Furthermore, the presence of H3F3A/ATRX-DAXX/TP53 mutations was strongly associated with alternative lengthening of telomeres and specific gene expression profiles. This is, to our knowledge, the first report to highlight recurrent mutations in a regulatory histone in humans, and our data suggest that defects of the chromatin architecture underlie paediatric and young adult GBM pathogenesis.
2,091 citations
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2,050 citations
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TL;DR: The most widely used technique for atomic-resolution force microscopy in vacuum is frequency-modulation AFM (FM-AFM), as well as other dynamic methods as discussed by the authors.
Abstract: This article reviews the progress of atomic force microscopy in ultrahigh vacuum, starting with its invention and covering most of the recent developments. Today, dynamic force microscopy allows us to image surfaces of conductors and insulators in vacuum with atomic resolution. The most widely used technique for atomic-resolution force microscopy in vacuum is frequency-modulation atomic force microscopy (FM-AFM). This technique, as well as other dynamic methods, is explained in detail in this article. In the last few years many groups have expanded the empirical knowledge and deepened our theoretical understanding of frequency-modulation atomic force microscopy. Consequently spatial resolution and ease of use have been increased dramatically. Vacuum atomic force microscopy opens up new classes of experiments, ranging from imaging of insulators with true atomic resolution to the measurement of forces between individual atoms.
1,948 citations
Authors
Showing all 10758 results
Name | H-index | Papers | Citations |
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Joseph Jankovic | 153 | 1146 | 93840 |
Robert J. Cava | 125 | 1042 | 71819 |
Christian Weber | 122 | 776 | 53842 |
Christa Meisinger | 106 | 589 | 54264 |
Thomas Braun | 96 | 744 | 38576 |
Peter Hänggi | 90 | 788 | 42272 |
Ali Guermazi | 89 | 732 | 31590 |
Darrell G. Schlom | 88 | 641 | 41470 |
Klaus Berger | 84 | 428 | 32352 |
Björn Schuller | 84 | 929 | 34713 |
Peter Fischer | 80 | 1055 | 32908 |
Aldo Steinfeld | 80 | 484 | 23684 |
Angela Döring | 78 | 226 | 30014 |
Alois Loidl | 78 | 951 | 27187 |
Winfried März | 74 | 361 | 36423 |