Institution
Austin Hospital
Healthcare•Melbourne, Victoria, Australia•
About: Austin Hospital is a healthcare organization based out in Melbourne, Victoria, Australia. It is known for research contribution in the topics: Intensive care & Population. The organization has 2729 authors who have published 3872 publications receiving 114931 citations.
Papers published on a yearly basis
Papers
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University of Pittsburgh1, Ghent University2, Research Foundation - Flanders3, University of Alberta4, Austin Hospital5, University of Miami6, University of California, San Diego7, University of Surrey8, The Chinese University of Hong Kong9, Medanta10, University of Bordeaux11, University of Helsinki12, Pontifical Catholic University of Chile13, Jikei University School of Medicine14, University of Western Australia15
TL;DR: This is the first multinational cross-sectional study on the epidemiology of AKI in ICu patients using the complete KDIGO criteria and found that AKI occurred in more than half of ICU patients.
Abstract: Current reports on acute kidney injury (AKI) in the intensive care unit (ICU) show wide variation in occurrence rate and are limited by study biases such as use of incomplete AKI definition, selected cohorts, or retrospective design. Our aim was to prospectively investigate the occurrence and outcomes of AKI in ICU patients. The Acute Kidney Injury–Epidemiologic Prospective Investigation (AKI-EPI) study was an international cross-sectional study performed in 97 centers on patients during the first week of ICU admission. We measured AKI by Kidney Disease: Improving Global Outcomes (KDIGO) criteria, and outcomes at hospital discharge. A total of 1032 ICU patients out of 1802 [57.3 %; 95 % confidence interval (CI) 55.0–59.6] had AKI. Increasing AKI severity was associated with hospital mortality when adjusted for other variables; odds ratio of stage 1 = 1.679 (95 % CI 0.890–3.169; p = 0.109), stage 2 = 2.945 (95 % CI 1.382–6.276; p = 0.005), and stage 3 = 6.884 (95 % CI 3.876–12.228; p < 0.001). Risk-adjusted rates of AKI and mortality were similar across the world. Patients developing AKI had worse kidney function at hospital discharge with estimated glomerular filtration rate less than 60 mL/min/1.73 m2 in 47.7 % (95 % CI 43.6–51.7) versus 14.8 % (95 % CI 11.9–18.2) in those without AKI, p < 0.001. This is the first multinational cross-sectional study on the epidemiology of AKI in ICU patients using the complete KDIGO criteria. We found that AKI occurred in more than half of ICU patients. Increasing AKI severity was associated with increased mortality, and AKI patients had worse renal function at the time of hospital discharge. Adjusted risks for AKI and mortality were similar across different continents and regions.
1,704 citations
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TL;DR: The RIFLE criteria for acute renal failure classified close to 20% of study patients as having some degrees of acute impairment in renal function and were useful in predicting their hospital mortality.
Abstract: Objective:The Acute Dialysis Quality Initiative (ADQI) Group published a consensus definition (the RIFLE criteria) for acute renal failure. We sought to assess the ability of the RIFLE criteria to predict mortality in hospital patients.Design:Retrospective single-center study.Setting:University-affi
877 citations
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TL;DR: The SD of glucose concentration is a significant independent predictor of intensive care unit and hospital mortality and decreasing the variability of blood glucose concentration might be an important aspect of glucose management.
Abstract: Background:Intensive insulin therapy may reduce mortality and morbidity in selected surgical patients. Intensive insulin therapy also reduced the SD of blood glucose concentration, an accepted measure of variability. There is no information on the possible significance of variability in glucose conc
776 citations
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TL;DR: Lyn-/- mice fail to mediate an allergic response to IgE cross-linking, indicating that activation of LYN plays an indispensable role in Fc epsilon RI signaling, particularly in establishing B cell tolerance.
711 citations
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TL;DR: A new vaccine design, with Ag covalently conjugated to solid core nano-beads of narrowly defined size inducing responses that were significantly higher than those elicited by other bead sizes, and higher than a range of currently used adjuvants.
Abstract: Infection can protect against subsequent disease by induction of both humoral and cellular immunity, but inert protein-based vaccines are not as effective. In this study, we present a new vaccine design, with Ag covalently conjugated to solid core nano-beads of narrowly defined size (0.04-0.05 microm) that localize to dendritic cells (DEC205(+) CD40(+), CD86(+)) in draining lymph nodes, inducing high levels of IFN-gamma production (CD8 T cells: precursor frequencies 1/5000 to 1/1000) and high Ab titers in mice. Conjugation of Ag to these nano-beads induced responses that were significantly higher (2- to 10-fold) than those elicited by other bead sizes, and higher than a range of currently used adjuvants (alum, QuilA, monophosphoryl lipid A). Responses were comparable to CFA/IFA immunization for Abs and ex vivo peptide-pulsed dendritic cell immunization for CD8 T cells. A single dose of Ag-conjugated beads protected mice from tumors in two different model challenges and caused rapid clearance of established tumors in mice. Thus, a range of Ags conjugated to nano-beads was effective as immunogens in both therapeutic and prophylactic scenarios.
656 citations
Authors
Showing all 2740 results
Name | H-index | Papers | Citations |
---|---|---|---|
Elliott M. Antman | 161 | 716 | 179462 |
Mark E. Cooper | 158 | 1463 | 124887 |
Mark J. Smyth | 153 | 713 | 88783 |
Rinaldo Bellomo | 147 | 1714 | 120052 |
Paul Mitchell | 146 | 1378 | 95659 |
John L. Hopper | 140 | 1229 | 86392 |
Samuel F. Berkovic | 132 | 757 | 63648 |
David Taylor | 131 | 2469 | 93220 |
John A. Eisman | 124 | 522 | 53539 |
Alan R. Zinsmeister | 118 | 542 | 52909 |
Geoffrey A. Donnan | 115 | 758 | 58971 |
Ian T. Baldwin | 113 | 642 | 47302 |
Ingrid E. Scheffer | 113 | 585 | 53463 |
Stephen M. Davis | 109 | 675 | 53144 |
John B. Carlin | 105 | 503 | 60976 |