Showing papers by "Banaras Hindu University published in 2012"
TL;DR: The generation, sites of production and role of ROS as messenger molecules as well as inducers of oxidative damage are described and the antioxidative defense mechanisms operating in the cells for scavenging of ROS overproduced under various stressful conditions of the environment are described.
Abstract: Reactive oxygen species (ROS) are produced as a normal product of plant cellular metabolism. Various environmental stresses lead to excessive production of ROS causing progressive oxidative damage and ultimately cell death. Despite their destructive activity, they are well-described second messengers in a variety of cellular processes, including conferment of tolerance to various environmental stresses. Whether ROS would serve as signaling molecules or could cause oxidative damage to the tissues depends on the delicate equilibrium between ROS production, and their scavenging. Efficient scavenging of ROS produced during various environmental stresses requires the action of several nonenzymatic as well as enzymatic antioxidants present in the tissues. In this paper, we describe the generation, sites of production and role of ROS as messenger molecules as well as inducers of oxidative damage. Further, the antioxidative defense mechanisms operating in the cells for scavenging of ROS overproduced under various stressful conditions of the environment have been discussed in detail.
4,012 citations
TL;DR: In this paper, the authors delineated the existing literature to examine the current status of various methods and technologies used for CO2 capture and separation from thermal power plant flue gas, including chemical-looping combustion, integrated gasification combined cycle, enzyme based separation, dual-alkali absorption approach, facilitated transport membrane, hydrate based separations, mixed matrix membrane and, calcium looping.
700 citations
TL;DR: The antidiabetic activity of medicinal plants is attributed to the presence of polyphenols, flavonoids, terpenoids, coumarins and other constituents which show reduction in blood glucose levels.
Abstract: Diabetes mellitus is one of the common metabolic disorders acquiring around 2.8% of the world's population and is anticipated to cross 5.4% by the year 2025. Since long back herbal medicines have been the highly esteemed source of medicine therefore, they have become a growing part of modern, high-tech medicine. In view of the above aspects the present review provides profiles of plants (65 species) with hypoglycaemic properties, available through literature source from various database with proper categorization according to the parts used, mode of reduction in blood glucose (insulinomimetic or insulin secretagogues activity) and active phytoconstituents having insulin mimetics activity. From the review it was suggested that, plant showing hypoglycemic potential mainly belongs to the family Leguminoseae, Lamiaceae, Liliaceae, Cucurbitaceae, Asteraceae, Moraceae, Rosaceae and Araliaceae. The most active plants are Allium sativum, Gymnema sylvestre, Citrullus colocynthis, Trigonella foenum greacum, Momordica charantia and Ficus bengalensis. The review describes some new bioactive drugs and isolated compounds from plants such as roseoside, epigallocatechin gallate, beta-pyrazol-1-ylalanine, cinchonain Ib, leucocyandin 3-O-beta-d-galactosyl cellobioside, leucopelargonidin-3- O-alpha-L rhamnoside, glycyrrhetinic acid, dehydrotrametenolic acid, strictinin, isostrictinin, pedunculagin, epicatechin and christinin-A showing significant insulinomimetic and antidiabetic activity with more efficacy than conventional hypoglycaemic agents. Thus, from the review majorly, the antidiabetic activity of medicinal plants is attributed to the presence of polyphenols, flavonoids, terpenoids, coumarins and other constituents which show reduction in blood glucose levels. The review also discusses the management aspect of diabetes mellitus using these plants and their active principles.
644 citations
TL;DR: In this paper, the authors summarized the results reported mainly within the last 10 years, and it is quite clear from the growing number of emerging publications in this field that the possibility to utilize multicomponent technology allows reaction conditions to be accessed that are very valuable for organic synthesis.
Abstract: Multicomponent reactions have gained significant importance as a tool for the synthesis of a wide variety of useful compounds, including pharmaceuticals. In this context, the multiple component approach is especially appealing in view of the fact that products are formed in a single step, and the diversity can be readily achieved simply by varying the reacting components. The eco-friendly, solvent-free multicomponent approach opens up numerous possibilities for conducting rapid organic synthesis and functional group transformations more efficiently. Additionally, there are distinct advantages of these solvent-free protocols since they provide reduction or elimination of solvents thereby preventing pollution in organic synthesis “at source”. The chemo-, regio- or stereoselective synthesis of high-value chemical entities and parallel synthesis to generate a library of small molecules will add to the growth of multicomponent solvent-free reactions in the near future. In this review we summarized the results reported mainly within the last 10 years. It is quite clear from the growing number of emerging publications in this field that the possibility to utilize multicomponent technology allows reaction conditions to be accessed that are very valuable for organic synthesis. Therefore, diversity oriented synthesis (DOS) is rapidly becoming one of the paradigms in the process of modern drug discovery. This has spurred research in those fields of chemical investigation that lead to the rapid assembly of not only molecular diversity, but also molecular complexity. As a consequence multi-component as well as domino or related reactions are witnessing a new spring.
420 citations
TL;DR: This review will initially describe current drug regimens and later will provide an overview on few important biochemical and enzymatic machineries that could be utilized as putative drug targets for generation of true antileishmanial drugs.
347 citations
TL;DR: Snail shell is a novel source for the production of heterogeneous base catalyst that can be successfully utilized for synthesis of biodiesel of high purity and the fuel properties of the biodiesel were found to be within the specifications.
346 citations
TL;DR: The information provided in this review will help the researchers for the development of an alternative methods rather than insulin and oral hypoglycemic agents for the treatment of diabetes mellitus, which will minimize the complication associated with the diabetes and related disorder.
Abstract: Diabetes mellitus is not a single disease but is a group of metabolic disorders affecting a huge number of population in the world. It is mainly characterized by chronic hyperglycemia, resulting from defects in insulin secretion or insulin action. It is predicated that the number of diabetes person in the world could reach upto 366 million by the year 2030. Even though the cases of diabetes are increasing day by day, except insulin and oral hypoglycemic drugs no other way of treatment has been successfully developed so far. Thus, the objective of the present review is to provide an insight over the pathophysiological and etiological aspects of diabetes mellitus along with the remedies available for this metabolic disorder. The review also contains brief idea about diabetes mellitus and the experimental screening model with their relevant mechanism and significance mainly used nowadays. Alloxan and streptozotocin are mainly used for evaluating the antidiabetic activity of a particular drug. This review contain list of medicinal plants which have been tested for their antidiabetic activity in the alloxan induced diabetic rat model. From the available data in the literature, it was found that plant having antidiabetic activity is mainly due to the presence of the secondary metabolite. Thus, the information provided in this review will help the researchers for the development of an alternative methods rather than insulin and oral hypoglycemic agents for the treatment of diabetes mellitus, which will minimize the complication associated with the diabetes and related disorder.
268 citations
TL;DR: This review focuses on AD related genes which are expressed during TBI and its relevance to progression of the disease and understanding will help to diagnose the risk of TBI patients to develop AD and design therapeutic interventions.
263 citations
TL;DR: In this paper, a 2D continuous random network glass supported on a bilayer of (SiO4) 2− tetrahedra and without detectable covalent bonding to the graphene was discovered.
Abstract: Large-area graphene substrates provide a promising lab bench for synthesizing, manipulating, and characterizing low-dimensional materials, opening the door to high-resolution analyses of novel structures, such as two-dimensional (2D) glasses, that cannot be exfoliated and may not occur naturally. Here, we report the accidental discovery of a 2D silica glass supported on graphene. The 2D nature of this material enables the first atomic resolution transmission electron microscopy of a glass, producing images that strikingly resemble Zachariasen's original 1932 cartoon models of 2D continuous random network glasses. Atomic-resolution electron spectroscopy identifies the glass as SiO2 formed from a bilayer of (SiO4) 2− tetrahedra and without detectable covalent bonding to the graphene. From these images, we directly obtain ring statistics and pair distribution functions that span short-, medium-, and long-range order. Ab initio calculations indicate that van der Waals interactions with graphene energetically stabilizes the 2D structure with respect to bulk SiO2. These results demonstrate a new class of 2D glasses that can be applied in layered graphene devices and studied at the atomic scale.
232 citations
China Agricultural University1, Pakistan Academy of Sciences2, Punjab Agricultural University3, International Maize and Wheat Improvement Center4, Nuclear Institute for Agriculture and Biology5, University of Zambia6, National Agricultural Research Centre7, Banaras Hindu University8, Sabancı University9
TL;DR: Foliar Zn application resulted in successful biofortification of wheat grain with Zn without causing yield loss, and can be locally adopted for increasing dietary Zn intake and fighting human Zn deficiency in rural areas.
Abstract: Aim
Zinc (Zn) fertilization is an effective agronomic tool for Zn biofortification of wheat for overcoming human Zn deficiency. But it still needs to be evaluated across locations with different management practices and wheat cultivars, since grain Zn concentrations may be significantly affected by locations, cultivars and management.
227 citations
TL;DR: This opinion article highlights three promising approaches that provide environmental and economic benefits of bioremediation: transgenics, low-input 'designer' plants and nanotechnology.
TL;DR: In this paper, a green polymeric material, polyacrylamide grafted with Okra mucilage, a natural grade polysaccharide, was tested as corrosion inhibitor for mild steel in 0.5 M H 2 SO 4 using gravimetric and electrochemical techniques.
TL;DR: In this article, the inhibition performance of four benzylidine malononitriles (BMNs) on mild steel was studied by weight loss, potentiodynamic polarization and electrochemical impedance spectroscopy (EIS).
Journal Article•
TL;DR: The accidental discovery of a 2D silica glass supported on graphene enables the first atomic resolution transmission electron microscopy of a glass, producing images that strikingly resemble Zachariasen's original 1932 cartoon models of 2D continuous random network glasses.
Abstract: Large-area graphene substrates provide a promising lab bench for synthesizing, manipulating, and characterizing low-dimensional materials, opening the door to high-resolution analyses of novel structures, such as two-dimensional (2D) glasses, that cannot be exfoliated and may not occur naturally. Here, we report the accidental discovery of a 2D silica glass supported on graphene. The 2D nature of this material enables the first atomic resolution transmission electron microscopy of a glass, producing images that strikingly resemble Zachariasen's original 1932 cartoon models of 2D continuous random network glasses. Atomic-resolution electron spectroscopy identifies the glass as SiO2 formed from a bilayer of (SiO4) 2− tetrahedra and without detectable covalent bonding to the graphene. From these images, we directly obtain ring statistics and pair distribution functions that span short-, medium-, and long-range order. Ab initio calculations indicate that van der Waals interactions with graphene energetically stabilizes the 2D structure with respect to bulk SiO2. These results demonstrate a new class of 2D glasses that can be applied in layered graphene devices and studied at the atomic scale.
TL;DR: In the p(T) < 4 GeV/c region dominated by thermal photons, a substantial direct-photon v(2) comparable to that of hadrons is found, whereas model calculations for thermal photons in this kinematic region underpredict the observed v( 2).
Abstract: The second Fourier component v(2) of the azimuthal anisotropy with respect to the reaction plane is measured for direct photons at midrapidity and transverse momentum (p(T)) of 1-12 GeV/c in Au + Au collisions at root s(NN) = 200 GeV. Previous measurements of this quantity for hadrons with p(T) 6 GeV/c a reduced anisotropy is interpreted in terms of a path-length dependence for parton energy loss. In this measurement with the PHENIX detector at the Relativistic Heavy Ion Collider we find that for p(T) > 4 GeV/c the anisotropy for direct photons is consistent with zero, which is as expected if the dominant source of direct photons is initial hard scattering. However, in the p(T) < 4 GeV/c region dominated by thermal photons, we find a substantial direct-photon v(2) comparable to that of hadrons, whereas model calculations for thermal photons in this kinematic region underpredict the observed v(2).
TL;DR: An overview on pharmacological activity and analytical techniques of Harmine is given, which may be useful for researcheres to explore the hidden potential of harmine and and will also help in developing new drugs for the treatment of various diseases.
Abstract: Harmine, a beta-carboline alkaloid, is widely distributed in the plants, marine creatures, insects, mammalians as well as in human tissues and body fluids. Harmine was originally isolated from seeds of Peganum harmal in 1847 having a core indole structure and a pyridine ring. Harmine has various types of pharmacological activities such as antimicrobial, antifungal, antitumor, cytotoxic, antiplasmodial, antioxidaant, antimutagenic, antigenotoxic and hallucinogenic properties. It acts on gamma-aminobutyric acid type A and monoamine oxidase A or B receptor, enhances insulin sensitivity and also produces vasorelaxant effect. Harmine prevents bone loss by suppressing osteoclastogenesis. The current review gives an overview on pharmacological activity and analytical techniques of harmine, which may be useful for researcheres to explore the hidden potential of harmine and and will also help in developing new drugs for the treatment of various diseases.
TL;DR: The luminescence intensity is improved significantly after core-shell formation due to extent of decrease of non-radiative rates arising from surface dangling bonds and capping agent and to improve crystallinity.
Abstract: Tb3+-doped CaMoO4 (Tb3+ = 1, 3, 5, 7, 10, 15 and 20 atom%) core and core–shell nanoparticles have been prepared by urea hydrolysis in ethylene glycol (EG) as capping agent as well as reaction medium at low temperature ∼150 °C. As-prepared samples were annealed at 500 and 900 °C for 4 h to eliminate unwanted hydrocarbons and/or H2O present in the sample and to improve crystallinity. The synthesised nanophosphors show tetragonal phase structure. The crystallite size of as-prepared sample is found to be ∼18 nm. The luminescence intensity of the 5D4 → 7F5 transition at 547 nm of Tb3+ is much higher than that of the 5D4 → 7F6 transition at 492 nm. 900 °C annealed samples show the highest luminescence intensity. The intensity ratio R (I[5D4 → 7F6]/I[5D4 → 7F5]) lies between 0.3–0.6 for as-prepared, 500 and 900 °C annealed samples. The luminescence decay of 5D4 level under 355 nm excitation shows biexponential behaviour indicating availability of Tb3+ ions on surface and core regions of particle; whereas, contribution of Mo–O charge transfer to lifetime is obtained under 250 nm excitation. The CIE coordinates of as-prepared, 500 and 900 °C annealed 5 atom% Tb3+-doped CaMoO4 samples under 250 nm excitation are (0.28, 0.32), (0.22, 0.28) and (0.25, 0.52), respectively. The dispersed particles in polar medium and its polymer film show green light emission. The luminescence intensity is improved significantly after core–shell formation due to extent of decrease of non-radiative rates arising from surface dangling bonds and capping agent. Quantum yields of as-prepared samples of 1, 5 and 7 atom% Tb3+-doped CaMoO4 samples are found to be 10, 3 and 2, respectively.
TL;DR: The isolation and characterization of a novel endophytic fungus from A. indica, which produces azadirachtin A and B in rich mycological medium (Sabouraud dextrose broth), under shake-flask fermentation conditions provides an exciting platform for further scientific exploration within both the ecological and biochemical contexts.
Abstract: Azadirachtin A and its structural analogues are a well-known class of natural insecticides having antifeedant and insect growth-regulating properties. These compounds are exclusive to the neem tree, Azadirachta indica A. Juss, from where they are currently sourced. Here we report for the first time, the isolation and characterization of a novel endophytic fungus from A. indica, which produces azadirachtin A and B in rich mycological medium (Sabouraud dextrose broth), under shake-flask fermentation conditions. The fungus was identified as Eupenicillium parvum by ITS analysis (ITS1 and ITS2 regions and the intervening 5.8S rDNA region). Azadirachtin A and B were identified and quantified by LC-HRMS and LC-HRMS2, and by comparison with the authentic reference standards. The biosynthesis of azadirachtin A and B by the cultured endophyte, which is also produced by the host neem plant, provides an exciting platform for further scientific exploration within both the ecological and biochemical contexts.
TL;DR: During in vivo investigations in food system all the five essential oils showed above 50% protection of chickpea seed from A. flavus infestation showing their potential as plant based preservatives for enhancement of shelf life of food items.
TL;DR: The three major QTL obtained can be used in marker-assisted selection for heat stress in wheat and explained more than 15 % phenotypic variation for HSITGW, HSIGFD and CTD.
Abstract: High temperature (>30 °C) at the time of grain filling is one of the major causes of yield reduction in wheat in many parts of the world, especially in tropical countries. To identify quantitative trait loci (QTL) for heat tolerance under terminal heat stress, a set of 148 recombinant inbred lines was developed by crossing a heat-tolerant hexaploid wheat (Triticum aestivum L.) cultivar (NW1014) and a heat-susceptible (HUW468) cultivar. The F5, F6, and F7 generations were evaluated in two different sowing dates under field conditions for 2 years. Using the trait values from controlled and stressed trials, four different traits (1) heat susceptibility index (HSI) of thousand grain weight (HSITGW); (2) HSI of grain fill duration (HSIGFD); (3) HSI of grain yield (HSIYLD); and (4) canopy temperature depression (CTD) were used to determine heat tolerance. Days to maturity was also investigated. A linkage map comprising 160 simple sequence repeat markers was prepared covering the whole genome of wheat. Using composite interval mapping, significant genomic regions on 2B, 7B and 7D were found to be associated with heat tolerance. Of these, two (2B and 7B) were co-localized QTL and explained more than 15 % phenotypic variation for HSITGW, HSIGFD and CTD. In pooled analysis over three trials, QTL explained phenotypic variation ranging from 9.78 to 20.34 %. No QTL × trial interaction was detected for the identified QTL. The three major QTL obtained can be used in marker-assisted selection for heat stress in wheat.
TL;DR: The enhanced mucoadhesiveness of CH-SA-CH DNPs results in higher bioavailability as compared to the uncoated nanoparticles, and Optimized formulation was found non-irritant and tolerable when tested by modified Draize test in rabbit eye.
TL;DR: The profiles of plants with hypoglycaemic properties reported in the literature from 2009 to 2011 are presented in a very interactive manner showing geographical region of availability, parts of plant used, mechanism of action and phytoconstituents responsible for particular action, to help intrested readers to easily identify and go for further research on the plant of their interest.
TL;DR: Gravimetric, electrochemical impedance spectroscopy (EIS), linear polarization resistance (LPR), and potentiodynamic polarization (PDP) studies were carried out to investigate the comparative corrosion protection efficiency of four condensed uracils (CUs) on mild steel in 1 M HCl as discussed by the authors.
Abstract: Gravimetric, electrochemical impedance spectroscopy (EIS), linear polarization resistance (LPR), and potentiodynamic polarization (PDP) studies were carried out to investigate the comparative corrosion protection efficiency of four condensed uracils (CUs) on mild steel in 1 M HCl. EIS plots indicated that the addition of inhibitors increases the charge-transfer resistance (Rct), decreases the double-layer capacitance (Cdl) of the corrosion process, and hence increases inhibition performance. Moreover, the thermodynamic activation parameters for the corrosion reaction were calculated and discussed in relation to the stability of the protective inhibitor layer. The morphology of the surface was examined by scanning electron microscopy (SEM), and the surface composition was evaluated using energy-dispersive X-ray spectroscopy (EDX) to verify the presence of inhibitor on the mild steel surface. Quantum chemical study suggests that the heterocyclic rings in these compounds are structurally essential for the pr...
TL;DR: The effect of Li+ co-doping on the photoluminescence properties of YPO4:Eu is discussed in this article, where interesting properties such as the presence of intermediate bands, shifting of the Eu-O CTB to a lower wavelength, variation in intensities of magnetic and electric dipole transitions of Eu3+ and shift of 5D0 → 7F0 to higher energy with increasing excitation wavelengths are observed.
Abstract: The effect of Li+ co-doping on the photoluminescence properties of YPO4:Eu is discussed. Interesting behaviours, such as the presence of intermediate bands, shifting of the Eu–O charge transfer band (Eu–O CTB) to a lower wavelength, variation in intensities of magnetic (5D0 → 7F1) and electric dipole (5D0 → 7F2) transitions of Eu3+ and shift of 5D0 → 7F0 to higher energy with increasing excitation wavelengths are observed. The Eu3+ ion does not have an absorption band in the range 340–350 nm, but after excitation at these wavelengths, a broad emission band (370–570 nm), as well as sharp peaks of Eu3+, could be observed. This is due to strong energy transfer from the intermediate band of the host to the Eu3+ ion. X-ray photoelectron spectroscopy (XPS) study also confirms that intermediate band emission is not due to Eu2+ ion emission. The blue shifting of Eu–O CTB is because of the increase in the optical electronegativity of the Eu3+ ion on Li+ co-doping. The variation in intensities of the 5D0 → 7F2 and 5D0 → 7F1 dipole transitions is related to (i) overlapping interaction parameters within the ground and excited states, (ii) exchange interaction among atoms/ions and (iii) density of the incoming photons. Shift of 5D0 → 7F0 to a higher energy with increasing excitation wavelengths is because of change in the second order crystal field parameter B20 with excitation wavelength. The significant enhancement of luminescence intensity is found with Li+ co-doping due to the increase in crystallinity.
TL;DR: In this article, the active control method is used for synchronization of two different pairs of fractional order systems with Lotka-Volterra chaotic system as the master system and the other two fractional-order chaotic systems, viz., Newton-Leipnik and Lorenz systems as slave systems separately.
Abstract: In this article, the active control method is used for synchronization of two different pairs of fractional order systems with Lotka–Volterra chaotic system as the master system and the other two fractional order chaotic systems, viz., Newton–Leipnik and Lorenz systems as slave systems separately. The fractional derivative is described in Caputo sense. Numerical simulation results which are carried out using Adams–Bashforth–Moulton method show that the method is easy to implement and reliable for synchronizing the two nonlinear fractional order chaotic systems while it also allows both the systems to remain in chaotic states. A salient feature of this analysis is the revelation that the time for synchronization increases when the system-pair approaches the integer order from fractional order for Lotka–Volterra and Newton–Leipnik systems while it reduces for the other concerned pair.
TL;DR: To evaluate the potentiality of three rhizosphere microorganisms in suppression of Sclerotinia rot in pea in consortia mode and their impact on host defence responses.
Abstract: Aims: To evaluate the potentiality of three rhizosphere microorganisms in suppression of Sclerotinia rot in pea in consortia mode and their impact on host defence responses.
Methods and Results: Pseudomonas aeruginosa PJHU15, Trichoderma harzianum TNHU27 and Bacillus subtilis BHHU100 from rhizospheric soils were selected based on compatibility, antagonistic and plant growth promotion activities. The microbes were used as consortia to assess their ability to trigger the phenylpropanoid and antioxidant activities and accumulation of proline, total phenol and pathogenesis-related (PR) proteins in pea under the challenge of the soft-rot pathogen Sclerotinia sclerotiorum. The triple-microbe consortium and single-microbe treatments showed 1·4–2·3 and 1·1–1·7-fold increment in defence parameters, respectively, when compared to untreated challenged control. Activation of the phenylpropanoid pathway and accumulation of total phenolics were highest at 48 h, whereas accumulation of proline and PR proteins along with activities of the antioxidant enzymes was highest at 72 h.
Conclusions: The compatible microbial consortia triggered defence responses in an enhanced level in pea than the microbes alone and provided better protection against Sclerotinia rot.
Significance and Impact of the Study: Rhizosphere microbes in consortium can enhance protection in pea against the soft-rot pathogen through augmented elicitation of host defence responses.
TL;DR: An insight is given about the various ɛ-PL producing strains, their screening procedures, mechanism of synthesis, characterization, and its application in the medical field.
TL;DR: This work proposes a less toxic, reproducible, and easy method for producing functionalized multilayer graphene from multiwalled carbon nanotubes (MWCNTs) in mass scale using only concentrated H(2)SO(4)/HNO(3).
Abstract: Multilayered graphene (MLG) is an interesting material for electrochemical sensing and biosensing because of its very large 2D electrical conductivity and large surface area. We propose a less toxic, reproducible, and easy method for producing functionalized multilayer graphene from multiwalled carbon nanotubes (MWCNTs) in mass scale using only concentrated H2SO4/HNO3. Electron microscopy results show the MLG formation, whereas FTIR and XPS data suggest its carboxylic and hydroxyl-functionalized nature. We utilize this functionalized MLG for the fabrication of a novel amperometric urea biosensor. This biosensor shows linearity of 10–100 mg dL–1, sensitivity of 5.43 μA mg–1 dL cm–2, lower detection limit of 3.9 mg dL–1, and response time of 10 s. Our results suggest that MLG is a promising material for electrochemical biosensing applications.
TL;DR: While up-regulated metabolic and antioxidative defense proteins, phytochelatin and GST work synchronously, the ars genes play a central role in detoxification and survival of Anabaena under As stress.
TL;DR: In this paper, four substituted pyranopyrazole derivatives (PPZs) were synthesized and their effects on the electrochemical behavior of mild steel in 1 M HCl were investigated using gravimetric measurements, Tafel extrapolation method, linear polarization resistance (LPR), and electrochemical impedance spectroscopy (EIS).
Abstract: Four substituted pyranopyrazole derivatives (PPZs) were synthesized and their effects on the electrochemical behavior of mild steel in 1 M HCl were investigated using gravimetric measurements, Tafel extrapolation method, linear polarization resistance (LPR), and electrochemical impedance spectroscopy (EIS). Tafel polarization measurements revealed that these compounds effectively suppressed both the anodic and cathodic processes of mild steel corrosion in acid solution and acted as mixed-type inhibitors. Scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX) examinations of electrode surface confirmed the existence of adherent layer of inhibitor on electrode surface. The UV–visible absorption spectrum of inhibitor solution containing mild steel indicated the formation of Fe–PPZ complex. Quantum chemical calculations have been used to evaluate the structural, electronic, and reactivity parameters of the selected pyranopyrazole derivatives in relation to their inhibition action.