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Institution

Banaras Hindu University

EducationVaranasi, Uttar Pradesh, India
About: Banaras Hindu University is a education organization based out in Varanasi, Uttar Pradesh, India. It is known for research contribution in the topics: Population & Dielectric. The organization has 11858 authors who have published 23917 publications receiving 464677 citations. The organization is also known as: Kashi Hindu Vishvavidyalay & Benares Hindu University.


Papers
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Journal ArticleDOI
TL;DR: In this article, the role of pH in green synthesis of silver nanoparticles (AgNPs) is investigated and two reaction pathways are proposed to explain the formation of AgNPs, keeping in view the pH changes that occur on addition of different amounts of NaOH.

140 citations

Journal ArticleDOI
TL;DR: A remarkable decrease in the in vitro DL cell proliferation and induction of the apoptosis by 1-4 is revealed, which lies in the order 2 > 1 > 4 > 3.
Abstract: Syntheses and characterizations of the arene ruthenium [(η6-C6H6)RuCl(4-mtdpm)] (1), [(η6-p-MeC6H4Pri)RuCl(4-mtdpm)] (2), and structurally analogous rhodium/iridium complexes [(η5-C5Me5)RhCl(4-mtdpm)] (3) and [(η5-C5Me5)IrCl(4-mtdpm)] (4) [4-mtdpm = 5-(4-methylthiophenyl)dipyrromethene] have been reported. Their identities have been established by satisfactory elemental analyses, electrospray ionization-mass spectrometry (ESI-MS), FT-IR, NMR (1H, 13C), UV/vis, emission spectral, and electrochemical studies. Structure of the representative complex 3 has been authenticated by X-ray single crystal analyses. The complexes 1–4 effectively bind with calf thymus DNA (CT DNA) through intercalative/electrostatic interactions. In addition, these exhibit significant cytotoxicity toward Dalton lymphoma (DL) cell line and cause static quenching of the bovine serum albumin (BSA) fluorophore. The antiproliferative activity, morphological changes, and apoptosis have been evaluated by MTT assay, acridine orange/ethidium b...

140 citations

Journal ArticleDOI
TL;DR: The essential structural features responsible for interaction with receptor site are established within a suggested pharmacophore and three compounds showed greater protection than sodium valproate.

139 citations

Journal ArticleDOI
TL;DR: The results of these experiments clearly demonstrate that f-CNT-AmB has significantly greater antileishmanial efficacy than AmB and had no significant cytotoxic effects.
Abstract: Methods: f-CNTs were prepared in a two-step chemical carboxylation and amidation process. The AmB was then attached to make f-CNT‐AmB and its construction was confirmed by Fourier transform infrared (FTIR) spectroscopy and transmission electron microscopy (TEM). The cytotoxicity of the constructed compound, f-CNT‐AmB, was assessed in vitro using the J774A.1 macrophage cell line and in vivo using healthy BALB/c mice. Antileishmanial activity of AmB and f-CNT‐AmB was assessed in vitro using a macrophage (J774A.1 cell line) model of Leishmania donovani infection. Antileishmanial activity was assessed in vivo by comparing the parasite load of hamsters treated with a 5 day course of AmB, f-CNTs or f-CNT‐AmB initiated at 30 days after infection with L. donovani parasites. Results: The FTIR spectroscopy and TEM data demonstrate the successful attachment of AmB to f-CNTs. The in vitro cytotoxicity of AmB, f-CNTs and f-CNT‐AmB was measured by the cytotoxic concentration required to kill 50% of the cells: 0.48+0.06 mg/mL; 7.31+1.16 mg/mL; 0.66+0.17 mg/mL, respectively, in the J774A.1 cell line. The in vivo toxicity assessment of the compounds in BALB/c mice revealed no hepatic or renal toxicity. Against intracellular amastigotes the in vitro antileishmanial efficacy of f-CNT‐AmB was significantly higher than that of AmB (IC50 0.00234+0.00075 mg/mL versus 0.03263+0.00123 mg/mL; P ≤0.0001). The percentage inhibition of amastigote replication in hamsters treated with f-CNT‐AmB was significantly more than that with AmB (89.85%+2.93% versus 68.97%+1.84%; P¼0.0004). Conclusions: The results of these experiments clearly demonstrate that f-CNT‐AmB has significantly greater antileishmanial efficacy than AmB and had no significant cytotoxic effects.

139 citations

Journal ArticleDOI
TL;DR: Results indicated that distribution of endophytic fungi within the A. marmelos is not even, which corroborates previous studies in same area and indicates that Bark harbors more endophyic fungi than leaf and root.
Abstract: Endophytic fungi were isolated from healthy, living, and symptomless tissues of inner bark, leaf, and roots of Aegle marmelos, a well-known medicinal plant, growing in different parts of India including Varanasi. A total of 79 isolates of endophytic fungi were isolated, representing 21 genera, adopting a standard isolation protocol. Members of the deuteromycotina were more prevalent than ascomycotina and others. The result was quite encouraging in terms of maximum isolates recovery from hyphomycetes (78.5%) followed by ascomycetes (8.9%) and coelomycetes (7.6%) respectively, which corroborates previous studies in same area. However, 5.1% isolates remained unidentified and were classified under Mycelia Sterilia. No isolate was obtained from either basidiomycotina or from zygomycotina. Fusarium spp. had maximum colonization frequency (8.00%) in this plant. The other dominant endophytic genera were Aspergillus spp., Alternaria sp., Drechslera sp., Rhizoctonia sp., Curvularia sp., Nigrospora sp., and Stenella sp. Only two ascomycetous members Chaetomium globosum and Emericella sp. (perfect state of Aspergillus sp.) were obtained from the bark sample. These results indicated that distribution of endophytic fungi within the A. marmelos is not even. Bark harbors more endophytic fungi than leaf and root.

139 citations


Authors

Showing all 12110 results

NameH-indexPapersCitations
Ashok Kumar1515654164086
Rajesh Kumar1494439140830
Prashant Shukla131134185287
Sudhir Malik130166998522
Vijay P. Singh106169955831
Rakesh Agrawal105668107569
Gautam Sethi10242531088
Jens Christian Frisvad9945331760
Sandeep Kumar94156338652
E. De Clercq9077430296
Praveen Kumar88133935718
Shyam Sundar8661430289
Arvind Kumar8587633484
Padma Kant Shukla84123235521
Brajesh K. Singh8340124101
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202399
2022351
20211,606
20201,336
20191,162
20181,053