Institution
Bar-Ilan University
Education•Ramat Gan, Israel•
About: Bar-Ilan University is a education organization based out in Ramat Gan, Israel. It is known for research contribution in the topics: Population & Poison control. The organization has 12835 authors who have published 34964 publications receiving 995648 citations. The organization is also known as: Bar Ilan University & BIU.
Papers published on a yearly basis
Papers
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TL;DR: It is suggested that low-level laser therapy in the visible and in the near-infrared region is due to cell respiration stimulation by either the endogenous porphyrins in the cell, or by the cytochromes.
Abstract: The effect of 360, 632 and 780 nm light on NIH fibroblast cells was examined. Mitosis counts of irradiated cells at various energy doses were taken. Scanning electron micrographs of these cells were studied. It is suggested that low-level laser therapy in the visible and in the near-infrared region is due to cell respiration stimulation by either the endogenous porphyrins in the cell, or by the cytochromes.
233 citations
Erasmus University Rotterdam1, Leiden University2, Rush University Medical Center3, California Pacific Medical Center4, University of Michigan5, Boston University6, National Institutes of Health7, University of Iceland8, University of Washington9, Harvard University10, Broad Institute11, Albert Einstein College of Medicine12, Oregon Health & Science University13, Group Health Cooperative14, University of California, Los Angeles15, Leiden University Medical Center16, Boston Children's Hospital17, Bar-Ilan University18, University of California, San Francisco19, University of Pittsburgh20
TL;DR: The inability to find new associations with survival to ages ≥90 years is because longevity represents multiple complex traits with heterogeneous genetic underpinnings, or alternatively, that longevity may be regulated by rare variants that are not captured by standard genome-wide genotyping and imputation of common variants.
Abstract: Background. The genetic contribution to longevity in humans has been estimated to range from 15% to 25%. Only two genes, APOE and FOXO3, have shown association with longevity in multiple independent studies. Methods. We conducted a meta-analysis of genome-wide association studies including 6,036 longevity cases, age90 years, and 3,757 controls that died between ages 55 and 80 years. We additionally attempted to replicate earlier identified single nucleotide polymorphism (SNP) associations with longevity. Results. In our meta-analysis, we found suggestive evidence for the association of SNPs near CADM2 (odds ratio [OR] = 0.81; p value = 9.66 × 10-7) and GRIK2 (odds ratio = 1.24; p value = 5.09 × 10-8) with longevity. When attempting to replicate findings earlier identified in genome-wide association studies, only the APOE locus consistently replicated. In an additional look-up of the candidate gene FOXO3, we found that an earlier identified variant shows a highly significant association with longevity when including published data with our meta-analysis (odds ratio = 1.17; p value = 1.85×10-10). Conclusions. We did not identify new genome-wide significant associations with longevity and did not replicate earlier findings except for APOE and FOXO3. Our inability to find new associations with survival to ages90 years because longevity represents multiple complex traits with heterogeneous genetic underpinnings, or alternatively, that longevity may be regulated by rare variants that are not captured by standard genome-wide genotyping and imputation of common variants.
233 citations
TL;DR: The better response rate of patients infected with HCV genotype 2 is multifactorial, the first finding of a difference in viral dynamics between subtypes of the same virus and demonstrates the importance of subtype-specific virus-host-drug interactions.
Abstract: Many studies have shown that patients infected with hepatitis C virus (HCV) of genotype 2 have better response to interferon (IFN)-alpha treatment than genotype 1 patients; however, the mechanisms responsible for this difference are not understood. In this study, viral dynamics during high-dose IFN induction treatment were compared between the genotypes. Patients in each group received 10 MU of IFN-alpha2b for 14 days, and HCV RNA levels were frequently determined. Nonlinear fitting, both individually for each patient and using a mixed-effects approach, of the viral kinetic data to a mathematical model of the IFN effect on HCV infection was performed. The antiviral effectiveness of IFN in blocking virus production, the free virion clearance rate, and the HCV-infected cell death rate were all significantly higher for genotype 2 patients than for genotype 1 patients. Thus, the better response rate of patients infected with HCV genotype 2 is multifactorial. This is the first finding of a difference in viral dynamics between subtypes of the same virus and demonstrates the importance of subtype-specific virus-host-drug interactions.
232 citations
TL;DR: Self-regulated compliance to mothers and caregivers--an early form of internalization--in 90 toddlers, half of whom were also observed with fathers, are examined, consistent with theoretical positions on the generalization of socialization from the mother to nonmaternal agents.
Abstract: To compare children's socialized behavior to parents and nonparental agents, this study examined self-regulated compliance to mothers and caregivers--an early form of internalization--in 90 toddlers, half of whom were also observed with fathers. Adults were observed in play, teaching, and discipline sessions with the child and were interviewed on child-rearing philosophies. Child cognition and emotion regulation were assessed, and naturalistic observations were conducted at child-care locations. Mean-level and rank-order stability were found in child compliance to the 3 adults. Child emotion regulation and adult warm control in a discipline situation were related to self-regulated compliance to the mother, caregiver, and father. Compliance to parents correlated with parental sensitivity and philosophies, and compliance to the caregiver correlated with child cognition and social involvement when child-care quality was controlled. Maternal sensitivity and warm control discipline predicted compliance to the caregiver but not vice versa. Results are consistent with theoretical positions on the generalization of socialization from the mother to nonmaternal agents.
232 citations
Columbia University1, University of Washington2, Google3, University of Science and Technology of China4, University of California, Berkeley5, Monash University6, Cornell University7, New York University8, University of Michigan9, University of British Columbia10, University of Freiburg11, Oregon Health & Science University12, Massachusetts Institute of Technology13, Harvard University14, Hastings Center15, University of Wisconsin-Madison16, Bar-Ilan University17, University of Maryland, College Park18, University of Pennsylvania19
TL;DR: Artificial intelligence and brain–computer interfaces must respect and preserve people's privacy, identity, agency and equality, say Rafael Yuste, Sara Goering and colleagues.
Abstract: Artificial intelligence and brain–computer interfaces must respect and preserve people's privacy, identity, agency and equality, say Rafael Yuste, Sara Goering and colleagues.
232 citations
Authors
Showing all 13037 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| H. Eugene Stanley | 154 | 1190 | 122321 |
| Albert-László Barabási | 152 | 438 | 200119 |
| Shlomo Havlin | 131 | 1013 | 83347 |
| Stuart A. Aaronson | 129 | 657 | 69633 |
| Britton Chance | 128 | 1112 | 76591 |
| Mark A. Ratner | 127 | 968 | 68132 |
| Doron Aurbach | 126 | 797 | 69313 |
| Jun Yu | 121 | 1174 | 81186 |
| Richard J. Wurtman | 114 | 933 | 53290 |
| Amir Lerman | 111 | 877 | 51969 |
| Zhu Han | 109 | 1407 | 48725 |
| Moussa B.H. Youdim | 107 | 574 | 42538 |
| Juan Bisquert | 107 | 450 | 46267 |
| Rachel Yehuda | 106 | 461 | 36726 |
| Michael F. Green | 106 | 485 | 45707 |