Institution
Bar-Ilan University
Education•Ramat Gan, Israel•
About: Bar-Ilan University is a education organization based out in Ramat Gan, Israel. It is known for research contribution in the topics: Population & Poison control. The organization has 12835 authors who have published 34964 publications receiving 995648 citations. The organization is also known as: Bar Ilan University & BIU.
Papers published on a yearly basis
Papers
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Austrian Institute of Technology1, Johns Hopkins University2, Utrecht University3, Ford Motor Company4, Bar-Ilan University5, ReNeuron6, Karolinska Institutet7, Salk Institute for Biological Studies8, Paracelsus Private Medical University of Salzburg9, National Tsing Hua University10, Royal Brisbane and Women's Hospital11, Hiroshima University12, National University of Singapore13, Tufts University14, Guangzhou Institutes of Biomedicine and Health15, Agency for Science, Technology and Research16, Tsinghua University17, University of Duisburg-Essen18
TL;DR: A review outlines topic‐specific action items that, if addressed, will enhance the development of best‐practice models for EV therapies and help to standardization and coordination of development efforts.
Abstract: Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell-related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened a Workshop on this topic to discuss the opportunities and challenges associated with development of EV-based therapeutics at the preclinical and clinical levels. This review outlines topic-specific action items that, if addressed, will enhance the development of best-practice models for EV therapies. Stem Cells Translational Medicine 2017;6:1730-1739.
232 citations
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TL;DR: In this paper, it is shown that all these seemingly unrelated phenomena owe their origin to the same underlying physical mechanism, namely, wave interaction with an open resonator, and it is possible to describe all of these effects in a unified way, mapping each system onto a simple resonator model.
Abstract: Super-resolution, extraordinary transmission, total absorption, and localization of electromagnetic waves are currently attracting growing attention. These phenomena are related to different physical systems and are usually studied within the context of different, sometimes rather sophisticated, approaches. Remarkably, all these seemingly unrelated phenomena owe their origin to the same underlying physical mechanism, namely, wave interaction with an open resonator. Here we show that it is possible to describe all of these effects in a unified way, mapping each system onto a simple resonator model. Such description provides a thorough understanding of the phenomena, explains all the main features of their complex behavior, and enables one to control the system via the resonator parameters: eigenfrequencies, $Q$ factors, and coupling coefficients.
232 citations
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TL;DR: It is shown that the genome has highly constrained dynamics, and suggested that the molecular regulation of chromatin diffusion by lamin A in the nuclear interior is critical for the maintenance of genome organization.
Abstract: Chromatin is organized in a highly ordered yet dynamic manner in the cell nucleus, but the principles governing this organization remain unclear. Similarly, it is unknown whether, and how, various proteins regulate chromatin motion and as a result influence nuclear organization. Here by studying the dynamics of different genomic regions in the nucleus of live cells, we show that the genome has highly constrained dynamics. Interestingly, depletion of lamin A strikingly alters genome dynamics, inducing a dramatic transition from slow anomalous diffusion to fast and normal diffusion. In contrast, depletion of LAP2α, a protein that interacts with lamin A and chromatin, has no such effect on genome dynamics. We speculate that chromosomal inter-chain interactions formed by lamin A throughout the nucleus contribute to chromatin dynamics, and suggest that the molecular regulation of chromatin diffusion by lamin A in the nuclear interior is critical for the maintenance of genome organization.
231 citations
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TL;DR: Mesure de reflectivite RX a la surface libre du 12CB a la transition isotrope-smectique A a the-sauveur de 9.10°C au dessus de la transition.
Abstract: We report x-ray reflectivity measurements on the free surface of dodecylcyanobiphenyl (12CB) at the isotropic to smectic-A phase transition. At about 10?deC above ${\mathrm{T}}_{\mathrm{IA}}$, smectic-A-like ordering develops at the surface while the bulk phase remains isotropic. The angular dependence of the specular reflectivity is consistent with a sinusoidal density modulation, starting at the surface and terminating abruptly, after an integral number of bilayers. As the transition is approached the number of layers increases in quantized steps from zero to five before the bulk undergoes a first-order transition to the smectic-A phase.
231 citations
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TL;DR: A highly discriminative and robust model is obtained, with an area under the curve of 0.95, for the iterative stochastic elimination optimization technique, used to build predictive models and to index natural products for their anticancer bioactivity.
Abstract: Cancer is considered one of the primary diseases that cause morbidity and mortality in millions of people worldwide and due to its prevalence, there is undoubtedly an unmet need to discover novel anticancer drugs. However, the traditional process of drug discovery and development is lengthy and expensive, so the application of in silico techniques and optimization algorithms in drug discovery projects can provide a solution, saving time and costs. A set of 617 approved anticancer drugs, constituting the active domain, and a set of 2,892 natural products, constituting the inactive domain, were employed to build predictive models and to index natural products for their anticancer bioactivity. Using the iterative stochastic elimination optimization technique, we obtained a highly discriminative and robust model, with an area under the curve of 0.95. Twelve natural products that scored highly as potential anticancer drug candidates are disclosed. Searching the scientific literature revealed that few of those molecules (Neoechinulin, Colchicine, and Piperolactam) have already been experimentally screened for their anticancer activity and found active. The other phytochemicals await evaluation for their anticancerous activity in wet lab.
231 citations
Authors
Showing all 13037 results
Name | H-index | Papers | Citations |
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H. Eugene Stanley | 154 | 1190 | 122321 |
Albert-László Barabási | 152 | 438 | 200119 |
Shlomo Havlin | 131 | 1013 | 83347 |
Stuart A. Aaronson | 129 | 657 | 69633 |
Britton Chance | 128 | 1112 | 76591 |
Mark A. Ratner | 127 | 968 | 68132 |
Doron Aurbach | 126 | 797 | 69313 |
Jun Yu | 121 | 1174 | 81186 |
Richard J. Wurtman | 114 | 933 | 53290 |
Amir Lerman | 111 | 877 | 51969 |
Zhu Han | 109 | 1407 | 48725 |
Moussa B.H. Youdim | 107 | 574 | 42538 |
Juan Bisquert | 107 | 450 | 46267 |
Rachel Yehuda | 106 | 461 | 36726 |
Michael F. Green | 106 | 485 | 45707 |