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Institution

Bar-Ilan University

EducationRamat Gan, Israel
About: Bar-Ilan University is a education organization based out in Ramat Gan, Israel. It is known for research contribution in the topics: Population & Poison control. The organization has 12835 authors who have published 34964 publications receiving 995648 citations. The organization is also known as: Bar Ilan University & BIU.


Papers
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Journal ArticleDOI
TL;DR: Results indicate that the induction of autophagy contributes to the radioresistance of these cells and Autophagy inhibitors may be employed to increase the sensitivity of CD133+ GSCs to γ‐radiation.
Abstract: Malignant gliomas are characterized by a short median survival which is largely impacted by the resistance of these tumors tochemo- and radiotherapy. Recent studies suggest that a small subpopulation of cancer stem cells, which are highly resistant to gamma-radiation, has the capacity to repopulate the tumors and contribute to their malignant progression. gamma-radiation activates the process of autophagy and inhibition of this process increases the radiosensitivity of glioma cells; however, the role of autophagy in the resistance of glioma stem cells (GSCs) to radiation has not been yet reported. In this study we examined the induction of autophagy by gamma-radiation in CD133+ GSCs. Irradiation of CD133+ cells induced autophagy within 24-48 hr and slightly decreased the viability of the cells. gamma-radiation induced a larger degree of autophagy in the CD133+ cells as compared with CD133- cells and the CD133+ cells expressed higher levels of the autophagy-related proteins LC3, ATG5 and ATG12. The autophagy inhibitor bafilomycin A1 and silencing of ATG5 and beclin1 sensitized the CD133+ cells to gamma-radiation and significantly decreased the viability of the irradiated cells and their ability to form neurospheres. Collectively, these results indicate that the induction of autophagy contributes to the radioresistance of these cells and autophagy inhibitors may be employed to increase the sensitivity of CD133+ GSCs to gamma-radiation.

313 citations

Journal ArticleDOI
TL;DR: In this paper, a rare surface freezing phenomenon is observed in normal alkanes, using x-ray and surface tension measurements, and an ordered monolayer forms on the surface of the liquid alkane at temperatures up to 3 \ifmmode^\circ\else\textdegree\fi{}C above the bulk freezing temperature.
Abstract: A rare surface freezing phenomenon is observed in molten normal alkanes, using x-ray and surface tension measurements. An ordered monolayer forms on the surface of the liquid alkane at temperatures up to 3 \ifmmode^\circ\else\textdegree\fi{}C above the bulk freezing temperature ${\mathrm{T}}_{\mathrm{f}}$. The structure of the monolayer was studied in detail for a wide range of molecular lengths and temperatures. The single layer formed persists down to ${\mathrm{T}}_{\mathrm{f}}$. The rare surface phase exists only for carbon numbers of 16\ensuremath{\leqslant}n\ensuremath{\leqslant}50. The molecules in the layer are hexagonally packed and show three distinct ordered phases: two rotator phases, with molecules oriented vertically (16\ensuremath{\leqslant}n\ensuremath{\leqslant}30) and tilted towards nearest neighbors (3044) and one crystalline phase with molecules tilted towards next-nearest neighbors (n\ensuremath{\geqslant}44). The temperature dependence of the surface tension and the range of existence vs carbon number are satisfactorily accounted for within a simple theory based on surface energy considerations.

313 citations

Journal ArticleDOI
Galit Ailon1
TL;DR: In this article, a critical reading of Geert Hofstede's Culture's Consequences using an analytical strategy where the book is mirrored against itself and analyzed in terms of its own proposed value dimensions is presented.
Abstract: The paper offers a critical reading of Geert Hofstede's (1980) Culture's Consequences using an analytical strategy where the book is mirrored against itself and analyzed in terms of its own proposed value dimensions. “Mirroring” unravels the book's normative viewpoint and political subtext and exposes discursive interests in its research process. Making all this evident in the canonical book's own terms, this paper communicates critical concerns across paradigm boundaries. It indicates the need to reconsider concepts and convictions that predominate cross-cultural research and to adopt norms of reflexivity that transcend existing notions of “cultural relativism.”

313 citations

Journal ArticleDOI
TL;DR: Capped nanoparticles are designed to target the virus and to compete for its binding to cellular HS through their sulfonate end groups, leading to the blockage of viral entry into the cell and to the prevention of subsequent infection.

313 citations


Authors

Showing all 13037 results

NameH-indexPapersCitations
H. Eugene Stanley1541190122321
Albert-László Barabási152438200119
Shlomo Havlin131101383347
Stuart A. Aaronson12965769633
Britton Chance128111276591
Mark A. Ratner12796868132
Doron Aurbach12679769313
Jun Yu121117481186
Richard J. Wurtman11493353290
Amir Lerman11187751969
Zhu Han109140748725
Moussa B.H. Youdim10757442538
Juan Bisquert10745046267
Rachel Yehuda10646136726
Michael F. Green10648545707
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023117
2022330
20212,286
20202,157
20191,920
20181,768