Showing papers by "Bareilly College published in 2008"
TL;DR: The results showed that oxidative stress was not uniformly affected in all the brain regions, and the cerebral cortex and brain stem showed a fall in oxidative stress after PS deprivation; the fall was greater in the adult than in the old animals.
Abstract: The present study examined the effects of paradoxical sleep (PS) deprivation on the oxidative stress parameters: lipid peroxidation, superoxide dismutase, glutathione peroxidase, and glutathione in brain regions: cerebral cortex, striatum, hippocampus, thalamus, hypothalamus, and brain stem of adult (8 months) and old (24 months) rats. PS deprivation (96 h) was performed by the classical flower pot technique. PS deprivation did not affect oxidative stress parameters in the striatum of both age groups; and the activity of glutathione peroxidase was not affected in any of the studied brain regions in both age groups. PS deprivation decreased the levels of glutathione only in the hippocampus, thalamus and hypothalamus; the magnitude of decrease was higher in the old than in the adult age group. PS deprivation increased the superoxide dismutase activity in the cerebral cortex and brain stem but reduced it in the hippocampus, thalamus and hypothalamus in both age groups. Increases in the activity were greater in adult animals than in old ones; the decline in the activity was greater in the hippocampus of old animals than in that of the adult ones. Lipid peroxidation was reduced by PS deprivation in the cerebral cortex and brain stem but was elevated in the hypothalamus and thalamus: the magnitude of alteration in the cerebral cortex, brain stem, hippocampus and hypothalamus was higher in adult animals than in old ones. The results showed that oxidative stress was not uniformly affected in all the brain regions. The cerebral cortex and brain stem showed a fall in oxidative stress after PS deprivation; the fall was greater in the adult than in the old animals. However, the oxidative stress was elevated in the hippocampus, thalamus and hypothalamus, and old animals were more severely affected than the adult ones.
75 citations
TL;DR: The study has shown that distance‐based and connectivity type indices are superior for modelling, monitoring and estimating CAII inhibition.
Abstract: Comparative quantitative structure–activity relationship studies on para-substituted aromatic sulphonamides carbonic anhydrase II (CAII) inhibitors are reported in this paper. The study is made utilizing (i) information indices along; (ii) distance-based and connectivity indices and (iii) combination of information, distance-based and connectivity type topological indices. The study has shown that distance-based and connectivity type indices are superior for modelling, monitoring and estimating CAII inhibition. The results are critically discussed using a variety of statistical parameters. Our results show that starting from the mono-parametric regression itself, our results are superior: Furthermore, our methodology allowed carrying out much higher-parametric regressions, yielding a nine-parametric model with R 2 as high as 0.8375. The eightparametric regression, gave R 2 = 0.8343. As there is not much difference, we have considered the eight-parametric regression the best.
31 citations
TL;DR: In this article, the performance of Rhodobryum giganteum and Hypnum cupressiforme as biomonitors was studied in relation to the accumulation of atmophile elements.
Abstract: Atmospheric distribution of metals was evaluated throughout the Garhwal Hills region of Uttaranchal, India by analysis of native moss species, Rhodobryum giganteum and Hypnum cupressiforme. The performance of these two mosses as biomonitors was studied in relation to the accumulation of atmophile elements. The elements Cd, Zn, Cu and Pb were surveyed at 33 sampling sites by conducting a passive monitoring technique using these mosses. Sampling was carried out from March 2004 to February 2005 for three different seasons (summer, monsoon and winter) in four directions nearly equidistant from a control site (Chamba Forest) where the moss samples were originally collected. Bioaccumulative ability in these two mosses was evaluated statistically using Dunkun’s Multiple Range test. Results indicate that summer has a significantly higher concentration of the metals Zn, Pb, Cu, Cd than winter and monsoon. Similarly, significant distance and seasonal differences were calculated and are presented on contour maps. The novel aspect of this study is that it actually delivered any information at all on atmospheric deposition in India and Asia, where very limited information is available in this field. Therefore, this finding is a gap filling one.
23 citations
TL;DR: In this paper, the excitation functions of a 12C+59Co projectile target system were measured up to 80 MeV and compared with the statistical model calculations by using the ALICE-91 and CASCADE codes.
Abstract: With the motivation of studying complete and incomplete fusion reactions in a 12C+59Co projectile target system, the excitation functions for (C, p3n), (C, 2p2n), (C, αn), (C, α2n), (C, αp3n) and (C, 2α2n) reactions have been measured up to 80 MeV. The well-known activation technique followed by offline high purity Ge γ-ray spectroscopy was used. The measured experimental values were compared with the statistical model calculations by using the ALICE-91 and CASCADE codes. For the calculations obtained by CASCADE, the variation of parameter Fθ, which is the ratio of actual moment of inertia to the rigid body value have also been studied. Considerable enhancement of the measured excitation functions compared to theoretical predictions for some channels clearly indicates the presence of incomplete fusion with complete fusion in the present projectile energy range. The measurements of forward recoil range distribution of evaporation residues at 80 MeV projectile energy confirm these observations.
13 citations
TL;DR: The results have shown that connectivity and shape type indices together with the distance‐based Wiener index (W) play a dominating role in modelling of mutagenicity (logTA100).
Abstract: Quantitative structure-activity relationship studies were performed to describe and predict the mutagenic activity of a set of 48 nitrated polycyclic aromatic hydrocarbons. From a larger pool of molecular descriptors (topological indices) we arrived at much a smaller set consisting of three correlating parameters. Such a variable selection is made using ncss software in that successive regressions were attempted using maximum-R(2) method. The results are critically discussed using a variety of statistical parameters. Our results have shown that connectivity and shape type indices together with the distance-based Wiener index (W) play a dominating role in modelling of mutagenicity (logTA100). The predictive ability of the models is discussed on the basis of cross-validated parameters.
12 citations
Journal Article•
TL;DR: The extent of the area affected by metal precipitation load in different rural and urban areas and abundance of metals in order of Zn > Pb > Cu > Cd is determined and Dhanaulti as most polluted location might be due to higher tourist activity and vehicular load.
Abstract: Metals Cu, Zn, Cd and Pb were surveyed at 14 sampling sites by using moss Hypnum cupressiforme through active monitoring technique. Samples were transplanted in all four directions of Mussoorie city and were harvested after exposure of four months (representing each season) to analyze metal precipitation and its trend at different sites during 2005. Bioaccumulation ability for metals was evaluated seasonally exhibiting maximum in summer followed by winter and minimum in rainy season. However, at some places Cu shows highly significant values in rainy season in comparison to winter. In case of Zn and Pb significantly different (p Pb > Cu > Cd.
9 citations
TL;DR: The CoMSIA reveals that only in case of series "D", the hydrophobic field effect is important and the activities of designed molecules are in better range and developed models might be helpful to design the potent ligands of BzR.
6 citations
TL;DR: Eigenvalue, eigenvector, and overlap matrix of the cobalt halide complex with thiazolidinethione have been estimated as discussed by the authors The theoretically estimated values of ligand field parameters such as Dq, B′, and β are very close to the experimental results.
Abstract: Eigenvalue, eigenvector, and overlap matrix of the cobalt halide complex with thiazolidinethione have been estimated The theoretically estimated values of ligand field parameters such as Dq, B′, and β are very close to the experimental results Hence, the theoretical methods based on molecular mechanics calculation can be well relied upon The eigenvector analysis and population analysis have shown that in bonding only s-and d orbitals are involved both in halides (CoX2) and their complexes (CoX2 · 2L) The involvement of p orbitals is negligible The sd hybridization is accordingly supported On the basis of these results sd
3 hybridization is supported The bond angles, total energy, and ligand field parameters estimated theoretically indicate that thiazolidinethione is coordinated to cobalt through its thioamide sulfur