Bareilly College

About: Bareilly College is a based out in . It is known for research contribution in the topics: Quantitative structure–activity relationship & Population. The organization has 171 authors who have published 214 publications receiving 2127 citations.

Chemometric modeling of breast cancer associated carbonic anhydrase IX inhibitors belonging to the ureido-substituted benzene sulfonamide class.

Abstract: Ureido-substituted benzene sulfonamides are the most important class of CA inhibitors which significantly inhibited the formation of primary tumors and metastases. Here, we present quantitative structure activity relationships (QSAR) study on a pool of 27 such inhibitors. A heuristic algorithm selected the best multiple linear regression (MLR) equation, showing the correlation between the observed values and the calculated values of activity. The calculated values of activity were in good agreement with the experimental values. The novelty of this work consists in not only exploring the structural attributes of bioactive molecules but also in predicting in silico the structures of new compounds which may show antimetastatic activity. The not yet synthesized such molecules (i.e. the prediction set) included many compounds showing a higher computed activity compared to the reported such derivatives, but they have been however not yet assayed.

Study of chromosomal abnormalities in Channa punctatus exposed to fenvalerate

Abstract: The chromosomal aberration test in kidney cells of Channa punctatus was conducted to study the genotoxic effect of synthetic pyrethroid fenvalerate, Different chromosomal abnormalities were seen and their frequency was recoded in metaphase spreads obtained from fishes exposed to three sub lethal concentrations (0.0625, 0.0314 and 0.0157 ppm) of this compound. The exposure to fenvalerate caused various structural abnormalities in chromosomes such as chromatid break, fragment, gap, chromatid separation, deletion and ring type chromosomes. Results obtained in present investigations clearly indicate that fenvalerate acts as a genotoxic agent in Channa punctatus.

Physiological studies on trematodes—lipid fractions in Gastrothylax crumenifer

Abstract: 1. The different lipid fractions in Gastrothylax crumenifer after starvation for 8–10 hr. have been estimated.2. The percentages of different fractions in the total ether extract were found to be: acetone-insoluble material 16, unsaponifiable matter 25, saturated fatty acids 5, unsaturated fatty acids 20, glycerol 2 and unidentified lipids 32.3. The above percentages of lipid fractions have been compared with the corresponding data for different parasites obtained by other workers.

Description of Pallisentis (Brevitritospinus) punctati n. sp. (Acanthocephala: Quadrigyridae) from Channa punctatus in Bareilly, Uttar Pradesh, India.

Abstract: Background: The genus Pallisentis is an endoparasitic acanthocephalan inhabit­ing the intestinal walls. Hooks and spines of the worm are significant taxonomical and adaptive tools. Methods: The parasites were fixed, dehydrated and examined under Olym­pus BX 53 Microscope with DIC attachment, digital camera and CELLSENS imag­ing system [Light microscopy (LM)] and fixed in 2% glutaraldehyde in 0.1 M cacodylate buffer, dehydrated, rotary-coated with gold palladium in NeoCoater 100-240V and examined in Neo JCM-6000 [scanning electron microscopy (SEM)]. Results: P. punctati n. sp. (prevalence 65.51%; mean intensity 3-6 par/host) is de­scribed. Females almost twice as large as males; proboscis hooks small; collar spine rows similar [16] and constant in both sexes but number of spines per row greater in females [22] than males [14]; trunk spine rows 28-39 (spines per row 14-18) in females and 20-26 (spines per row 10-12) in males. spine length of females almost twice as long as males, spines extend up to posterior testis in males and ¾ of total body length in females, Saefftigen’s pouch present, nuclei in cement gland 10-11, seminal vesicle, bursa and egg size small. SEM indicated lack of micro sculptures, and spines embedded on pre-trunk and trunk. Sex-based differences apparent (hook sizes, greater number of spines per row and longer spines in pre-trunk and trunk of females). Male trunk spine was narrower and of lateral spine with characteristic hooked appearance. Conclusion: A new species of Pallisentis based on LM and SEM is described, sexual diversity in hook and spine structure is reported.