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Bareilly College

About: Bareilly College is a based out in . It is known for research contribution in the topics: Quantitative structure–activity relationship & Population. The organization has 171 authors who have published 214 publications receiving 2127 citations.


Papers
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Journal ArticleDOI
TL;DR: Adult Ascaridia galli and Heterakis gallinae obtained from the fowl were treated in vitro with 10(-2) to 10(-5) M parbendazole and piperazine adipate and the activities of lactate dehydrogenase and alkaline phosphomonoesterase were not affected significantly.

6 citations

Journal ArticleDOI
TL;DR: The novelty of this work is not only to explore the structural attributes of bioactive molecules but also to design and predict in silico the STPCA inhibitory activity of new not yet synthesized compounds.

6 citations

Journal ArticleDOI
TL;DR: The CoMSIA reveals that only in case of series "D", the hydrophobic field effect is important and the activities of designed molecules are in better range and developed models might be helpful to design the potent ligands of BzR.

6 citations

Journal ArticleDOI
Madan M. Goil1
TL;DR: The oxygen consumption of the experimental parasite has been found to be very low and there is a marked difference in QO2 values of the whole and minced parasite.
Abstract: 1. The Q O 2 of adult F. gigantica has been compared with F. hepatica. 2. The oxygen consumption of the experimental parasite has been found to be very low. 3. There is a marked difference in Q O 2 values of the whole and minced parasite.

6 citations

Journal ArticleDOI
Shalini Singh1
TL;DR: In this paper, the authors present results of QSAR studies realized with the PRECLAV (Property Evaluation by Class Variables) software, which contains 66 derivatives of aromatic benzene sulfonamides incorporating 1, 3, 5-triazine moieties, fluorophenyl sulfamates, S-substituted-2-mercaptobenzenesulfonamide and diazenylbenzenes sulfonamide with clinically used CA inhibitors.
Abstract: This paper presents results of QSAR (Quantitative Structure Activity Relationship) studies realized with the PRECLAV (Property Evaluation by Class Variables) software. The database contains 66 derivatives of aromatic benzene sulfonamides incorporating 1, 3, 5-triazine moieties, fluorophenyl sulfamates, S-substituted-2-mercaptobenzenesulfonamide and diazenylbenzenesulfonamides with clinically used CA inhibitors. For each molecule over 3600 descriptors were calculated using programs MOPAC, PRECLAV and DRAGON. A heuristic algorithm selects the best multiple linear regression (MLR) equation showed that the correlation between the observed values and the calculated values of activity is very good (N = 66, Se = 0.263, r(2) = 0.884, F = 92.98, r(2)(cv) = 0.859, Q = 0.794). The virtual molecular fragments that lead to a significant increase of the inhibitor activity of hCA IX are C(3)H(2)N(5)Cl, NH(2), C(6)H(4), C(3)H(5)N(6), COOH, and C(3)HN(6). The virtual fragment--HO, C(5)H(2)NO, C(3)HN(6), leads to a significant decrease of the inhibitor activity value. With a view to external validation, the calibration set includes 50 molecules (Se = 0.256, r(2) = 0.885, F = 69.501, r(2)(cv) = 0.852) and the validation set includes 16 molecules (Se = 0.111, r(2) = 0.87, F = 93.984). Identification of molecules in validation set with high estimated value of inhibitory activity of hCA IX is correct enough to have practical value, even if the calibration/validation set contains aromatic benzene sulfonamides incorporating 1,3,5-triazine moieties and fluor phenyl sulfamates derivatives with very different chemical structures.

6 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202111
20209
20193
20189
20175
20162