Başkent University

About: Başkent University is a education organization based out in Ankara, Turkey. It is known for research contribution in the topics: Transplantation & Population. The organization has 4652 authors who have published 10380 publications receiving 143117 citations. The organization is also known as: Başkent Üniversitesi.

Factors affecting parametrial involvement in cervical cancer patients with tumor size ≤4 cm and selection of low-risk patient group

Abstract: Objective The primary aim of this study was to evaluate the factors affecting parametrial involvement in cervical cancer patients with tumor size ≤4 cm and selection of the low-risk patient group based on long-term oncologic outcomes. Material and methods Cervical cancer patients operated in the gynecologic oncology division between 2007 and 2013 were retrospectively evaluated. One-hundred and sixty-eight patients with tumor size ≤4 cm were identified. Of these, 159 (86.8%) underwent radical hysterectomy plus pelvic-para-aortic lymphadenectomy and nine (13.2%) underwent fertility-sparing surgery [radical trachelectomy (n=7); large conization (n=2)]. Factors affecting parametrial invasion, including lymphovascular space invasion (LVSI), deep stromal invasion (DSI), lymph node metastases, and tumor size, were evaluated. Statistical analyses were performed using SPSS 23.0 (IBM Corp., Armonk, NY, USA). Results Median age was 49.5 years and median tumor size was 2.5 cm (0.45-4 cm). In both univariate and multivariate analyses, the risk of parametrial involvement was increased with LVSI with a hazard ratio (HR) of 3.45 [95% confidence interval (CI): 1.1-10.8] and DSI with a HR of 4.1 (95% CI: 1.18-14.8), while tumor size of ≤2 cm was only significant in univariate analyses. Furthermore, 26 early-stage patients were identified with low-risk factors and they had no parametrial involvement, lymph node metastases, recurrence, or death from disease over 77 months. Conclusion Parametrial involvement in low-risk cervical cancer is very rare and less radical procedures may be safe in these patients.

City hospitals model in biomedical calibration service

Abstract: Clinical engineering comprise of management of medical technology, medical device maintenance, repair, and calibration which they are bought according to capacity of health institution. In this study, entirely using principles have been given about medical device maintenance, repair, and calibration. A model has been designed which is biomedical calibration production service to new vast city hospitals. The hospitals have high bed capacity and because of that there are more different types of medical devices in their inventory. According to the model has been depicted about separating medical devices too. Besides, process planning has been materialized in biomedical calibration. A new work flow model has been suggested result of evaluating both of calibration and preventive maintenance. Moreover in this study mentioned about laboratory accreditation to international traceability need. Furthermore an offset investment model has been examined to medical device calibrators which they will have bought city hospitals. Urgent actions have detected for all consider authority to the investment model success.

Frontal Sinus Surgery

Abstract: First of all we must recognize that the frontal sinus surgery is the most laborious intervention performed on the paranasal cavities and the ESS was elected for the simplification of these operations. Currently, endoscopic frontal sinus surgery is preferred in the treatment of the majority of these sinus diseases, except complicated frontal sinusitis and the extended tumoral pathology in which endoscopic approaches often fail or disseminate the disease. That is why the surgeon must possess the whole range of the classical techniques, and by the convertibility of a FESS, to be capable to apply the best solution for the patient’s pathology. External and intranasal frontal sinus approaches (i.e. trephination, radical ablation procedures, conservative intranasal techniques, external frontoethmoidectomy and osteoplastic anterior wall approach) have been used for the treatment of frontal sinus pathologies. Due to the poor outcome and unsatisfactory aesthetic results of the classical proceedings and thanks to the technological improvement in imaging systems together with the use of endoscopes and microscopes, these single and combined approaches have been widely adopted. After 1985 David Kennedy and Heinz Stammberger developed the EES(S) regardful of the Austrian technique FESS. In 1989, Schaefer and Close used the modified Messerklinger operation for the treatment of frontal sinus diseases. Later, Draf applied both endoscope and microscope in the treatment of frontal diseases.

Genetic Studies in Autism: Correspondence.

Abstract: To the Editor: I read with interest the recently published article in Indian Journal of Pediatrics discussing the various genetic causes and appropriate applications in the evaluation of a child with autism spectrum disorders [1]. However, in this study, I think that there are some points that need to be emphasized and discussed upon. First, Figure 4 demonstrates an algorithm that denotes a geneticist approach towards a child presented with autism. It is stated that the serum lactate, amino acids, ammonia, acylcarnitine profile, urine mucopolysaccharides and organic acids are classified and specified as the standard and prominent metabolic tests depending upon the clinical phenotype [1]. However, I think that the determination of urinary guanidinoacetate and creatine to creatinine ratio should also be recommended to screen cerebral creatine deficiency syndromes (CDS) in a child with autism. In addition to SLC6A8 deficiency, GAMT (Guanidioacetate methyltransferase) deficiency (OMIM: 612,736) is also associated with behavioral disturbances, such as autism and aggression/hyperactivity [2]. The plasma creatine level is low in patients with GAMT deficiency, but the levels are largely influenced by nutritional status and normal levels do not exclude the presence of CDS. Thus, it is recommended to determine urinary guanidinoacetate and creatine/creatinine ratio to screen all CDS. Urinary guanidinoacetate is high in GAMT deficiency and an increased urinary creatine/creatinine ratio is characteristic for SLC6A8 deficiency. In addition, creatine is one of the compounds examined inMR spectroscopy. Therefrom, brain MR spectroscopy beyond brain MRI should also be performed to evaluate creatine peak in these patients [2, 3]. Secondly, in evaluating unexplained behavioral disturbances and autism, particularly when it occurs in male members of the family, monoamine oxidase-A deficiency (OMIM: 300,615) should be kept in mind and it might be worthwhile screening for monoamines in random urine samples of these patients [3, 4]. HVA/VMA ratio above 4 in urine may be used as the first screening test, and then it can be reliably diagnosed by measuring the VMA, normetanephrine, and 3-methoxy-4hydroxyphenylethyleneglycol in urine [3, 5]. In conclusion, the expanding screening tests for inborn errors of metabolism in patients with autism may help to diagnose more patients. Halil Ibrahim Aydin Başkent University Medical Faculty, Department of Pediatrics, Section of Inborn Errors of Metabolism, Temel Kuguluoglu Sokak, No: 24/2 Bahçelievler, Ankara, Turkey. E-mail: hiaydin@yahoo.com

Assessment of eating attitudes and body satisfaction among high school adolescents in Turkey

Abstract: Background/aims: This research aimed to investigate the relationship between eating attitudes and body satisfaction among adolescents attending high school in Ankara, the capital city of Turkey. Methods: The participants were 718 males and 761 females, in total 1479 adolescents aged between 13 and 18 years. The Eating Attitude Test-26 (EAT-26) and Body Cathexis Scale (BCS) were used to assess eating attitudes and body satisfaction respectively. Data from the study were evaluated statistically by chi-square test. Results: Our results showed that 2.93 % of males and 40.07 of females faced a high risk of having an eating disorder. Our findings confirm that females are more at risk of eating disorders. The BCS of males (90.8 ± 20.8) was found significantly higher than females (81.3 ± 16.8) ( p<0.001), which indicates that females are less content than about their appearance. We also found that 6.3 % of males and 18.2 % of females thought that they were overweight, and 22.9% of females and 4.3 % of males perceived themselves as obese. While 58.6 % of males perceived their body image as correct, 65.8 % of females did not (p<0.05). Conclusion: Together these results confirm that female adolescents tend to be less satisfied with their weight and more likely to display disordered eating attitudes. Keywords: Adolescents, Eating Attitude Test-26, Body Cathexis Scale, Body Satisfaction