Beijing University of Technology

About: Beijing University of Technology is a education organization based out in Beijing, Beijing, China. It is known for research contribution in the topics: Microstructure & Computer science. The organization has 31929 authors who have published 31987 publications receiving 352112 citations. The organization is also known as: Běijīng Gōngyè Dàxué & Beijing Polytechnic University.

Tumor Energy Metabolism and Potential of 3-Bromopyruvate as an Inhibitor of Aerobic Glycolysis: Implications in Tumor Treatment.

Abstract: Tumor formation and growth depend on various biological metabolism processes that are distinctly different with normal tissues. Abnormal energy metabolism is one of the typical characteristics of tumors. It has been proven that most tumor cells highly rely on aerobic glycolysis to obtain energy rather than mitochondrial oxidative phosphorylation (OXPHOS) even in the presence of oxygen, a phenomenon called “Warburg effect”. Thus, inhibition of aerobic glycolysis becomes an attractive strategy to specifically kill tumor cells, while normal cells remain unaffected. In recent years, a small molecule alkylating agent, 3-bromopyruvate (3-BrPA), being an effective glycolytic inhibitor, has shown great potential as a promising antitumor drug. Not only it targets glycolysis process, but also inhibits mitochondrial OXPHOS in tumor cells. Excellent antitumor effects of 3-BrPA were observed in cultured cells and tumor-bearing animal models. In this review, we described the energy metabolic pathways of tumor cells, mechanism of action and cellular targets of 3-BrPA, antitumor effects, and the underlying mechanism of 3-BrPA alone or in combination with other antitumor drugs (e.g., cisplatin, doxorubicin, daunorubicin, 5-fluorouracil, etc.) in vitro and in vivo. In addition, few human case studies of 3-BrPA were also involved. Finally, the novel chemotherapeutic strategies of 3-BrPA, including wafer, liposomal nanoparticle, aerosol, and conjugate formulations, were also discussed for future clinical application.

Research Challenges and Perspectives on Wisdom Web of Things (W2T).

Abstract: The rapid development of the Internet and the Internet of Things accelerates the emergence of the hyper world. It has become a pressing research issue to realize the organic amalgamation and harmonious symbiosis among humans, computers, and things in the hyper world, which consists of the social world, the physical world, and the information world (cyber world). In this paper, the notion of Wisdom Web of Things (W2T) is proposed in order to address this issue. As inspired by the material cycle in the physical world, the W2T focuses on the data cycle, namely "from things to data, information, knowledge, wisdom, services, humans, and then back to things." A W2T data cycle system is designed to implement such a cycle, which is, technologically speaking, a practical way to realize the harmonious symbiosis of humans, computers, and things in the emerging hyper world.