Showing papers by "Ben-Gurion University of the Negev published in 2005"

Evaluating 2-DNF formulas on ciphertexts

Abstract: Let ψ be a 2-DNF formula on boolean variables x1,...,xn ∈ {0,1}. We present a homomorphic public key encryption scheme that allows the public evaluation of ψ given an encryption of the variables x1,...,xn. In other words, given the encryption of the bits x1,...,xn, anyone can create the encryption of ψ(x1,...,xn). More generally, we can evaluate quadratic multi-variate polynomials on ciphertexts provided the resulting value falls within a small set. We present a number of applications of the system: In a database of size n, the total communication in the basic step of the Kushilevitz-Ostrovsky PIR protocol is reduced from $\sqrt{n}$ to $\sqrt[3]{n}$. An efficient election system based on homomorphic encryption where voters do not need to include non-interactive zero knowledge proofs that their ballots are valid. The election system is proved secure without random oracles but still efficient. A protocol for universally verifiable computation.

Practical privacy: the SuLQ framework

Abstract: We consider a statistical database in which a trusted administrator introduces noise to the query responses with the goal of maintaining privacy of individual database entries. In such a database, a query consists of a pair (S, f) where S is a set of rows in the database and f is a function mapping database rows to {0, 1}. The true answer is ΣieSf(di), and a noisy version is released as the response to the query. Results of Dinur, Dwork, and Nissim show that a strong form of privacy can be maintained using a surprisingly small amount of noise -- much less than the sampling error -- provided the total number of queries is sublinear in the number of database rows. We call this query and (slightly) noisy reply the SuLQ (Sub-Linear Queries) primitive. The assumption of sublinearity becomes reasonable as databases grow increasingly large.We extend this work in two ways. First, we modify the privacy analysis to real-valued functions f and arbitrary row types, as a consequence greatly improving the bounds on noise required for privacy. Second, we examine the computational power of the SuLQ primitive. We show that it is very powerful indeed, in that slightly noisy versions of the following computations can be carried out with very few invocations of the primitive: principal component analysis, k means clustering, the Perceptron Algorithm, the ID3 algorithm, and (apparently!) all algorithms that operate in the in the statistical query learning model [11].

Microorganisms and microalgae as sources of pigments for food use: a scientific oddity or an industrial reality?

Abstract: Pigments producing microorganisms and microalgae are quite common in Nature. However, there is a long way from the Petri dish to the market place. Five productions, using Monascus, Penicillium, Dunaliella, Haematococcus and Porphyridium, are discussed. Some companies invested a lot of money as any combination of new source and/or new pigment drives a lot of experimental work, process optimization, toxicological studies and regulatory issues. Time will tell whether investments were cost-effective. Future trends involve combinatorial engineering and production of niche pigments not found in plants.

Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic agents.

Abstract: Objective. To investigate the effect of 2 different species of probiotics in preventing infections in infants attending child care centers. Methods. A double-blind, placebo-controlled, randomized trial was conducted from December 1, 2000, to September 30, 2002, at 14 child care centers in the Beer-Sheva area of Israel in healthy term infants 4 to 10 months old. Infants were assigned randomly to formula supplemented with Bifidobacterium lactis (BB-12), Lactobacillus reuteri (American Type Culture Collection 55730), or no probiotics. Duration of feeding, including follow-up, for each participant was 12 weeks. All infants were fed only the assigned formula and were not breastfed due to parental decision before recruitment to the study. Probiotic or prebiotic food products or supplements were not allowed. Main outcome measures were number of days and number of episodes with fever (>38°C) and number of days and number of episodes with diarrhea or respiratory illness. Results. Participants ( n = 201) were similar regarding gestational age, birth weight, gender, and previous breastfeeding. The controls ( n = 60), compared with those fed B lactis ( n = 73) or L reuteri ( n = 68), had significantly more febrile episodes (mean [95% confidence interval]: 0.41 [0.28–0.54] vs 0.27 [0.17–0.37] vs 0.11 [0.04–0.18], respectively). The controls also had more diarrhea episodes (0.31 [0.22–0.40] vs 0.13 [0.05–0.21] vs 0.02 [0.01–0.05], respectively) and episodes of longer duration (0.59 [0.34–0.84] vs 0.37 [0.08–0.66] vs 0.15 [0.12–0.18] days, respectively). The L reuteri group, compared with BB-12 or controls, had a significant decrease of number of days with fever, clinic visits, child care absences, and antibiotic prescriptions. Rate and duration of respiratory illnesses did not differ significantly between groups. Conclusions. Child care infants fed a formula supplemented with L reuteri or B lactis had fewer and shorter episodes of diarrhea, with no effect on respiratory illnesses. These effects were more prominent with L reuteri , which was also the only supplement to improve additional morbidity parameters.

A giant γ-ray flare from the magnetar SGR 1806–20

Abstract: On 27 December last year, SGR1806–20, a soft γ-ray repeater in Sagittarius, released a giant flare that has been called the brightest explosion ever recorded. SGRs are X-ray stars that sporadically emit low-energy γ-ray bursts. They are thought to be magnetars: neutron stars with observable emissions powered by magnetic dissipation. Five papers in this issue report initial and follow-up observations of this event. The data are remarkable: for instance in a fifth of a second, the flare released as much energy as the Sun radiates in a quarter of a million years. Such power can be explained by catastrophic global crust failure and magnetic reconnection on a magnetar. Releasing a hundred times the energy of the only two previous SGR giant flares, this may have been a once-in-a-lifetime event for astronomers, and for the star itself. Two classes of rotating neutron stars—soft γ-ray repeaters (SGRs) and anomalous X-ray pulsars—are magnetars1, whose X-ray emission is powered by a very strong magnetic field (B ≈ 1015 G). SGRs occasionally become ‘active’, producing many short X-ray bursts. Extremely rarely, an SGR emits a giant flare with a total energy about a thousand times higher than in a typical burst2,3,4. Here we report that SGR 1806–20 emitted a giant flare on 27 December 2004. The total (isotropic) flare energy is 2 × 1046 erg, which is about a hundred times higher than the other two previously observed giant flares. The energy release probably occurred during a catastrophic reconfiguration of the neutron star's magnetic field. If the event had occurred at a larger distance, but within 40 megaparsecs, it would have resembled a short, hard γ-ray burst, suggesting that flares from extragalactic SGRs may form a subclass of such bursts.

Analysis and design of spherical microphone arrays

Abstract: Spherical microphone arrays have been recently studied for sound-field recordings, beamforming, and sound-field analysis which use spherical harmonics in the design. Although the microphone arrays and the associated algorithms were presented, no comprehensive theoretical analysis of performance was provided. This work presents a spherical-harmonics-based design and analysis framework for spherical microphone arrays. In particular, alternative spatial sampling schemes for the positioning of microphones on a sphere are presented, and the errors introduced by finite number of microphones, spatial aliasing, inaccuracies in microphone positioning, and measurement noise are investigated both theoretically and by using simulations. The analysis framework can also provide a useful guide for the design and analysis of more general spherical microphone arrays which do not use spherical harmonics explicitly.

Microwave‐Assisted Synthesis of Nanocrystalline MgO and Its Use as a Bacteriocide

Abstract: Nanocrystalline particles of MgO were synthesized using microwave radiation in an ethylene glycol solution. The antibacterial activities of the MgO nanoparticles were tested by treating Escherichia coli (Gram negative) and Staphylococcus aureus (Gram positive) cultures with 1 mg mL–1 of the nanoparticles. We have examined the importance of the size effect, pH, and the form of the active MgO species as a bactericidal agent. A clear size dependence of the nanoparticles is observed where the amount of eradicated bacteria was strongly dependent on the particle size.

Accelerated Atherosclerosis in Autoimmune Rheumatic Diseases

Abstract: Received October 16, 2004; revision received June 4, 2005; accepted June 7, 2005 Atherosclerosis is a multifactorial process that commences in childhood but manifests clinically later in life Atherosclerosis is increasingly considered an immune system–mediated process of the vascular system The presence of macrophages and activated lymphocytes within atherosclerotic plaques supports the concept of atherosclerosis as an immune system–mediated inflammatory disorder1,2 Inflammation can aggravate atherosclerosis via different mechanisms secondary to autoimmunity, infectious diseases, and other proatherogenic changes that occur during the inflammatory state Autoimmune rheumatic diseases (AIRDs) are associated with higher rates of cardiovascular morbidity and mortality, primarily secondary to accelerated atherosclerosis This phenomenon can be attributed to traditional risk factors for atherosclerosis and use of specific drugs, such as corticosteroids, but also might be the result of other autoimmune and inflammatory mechanisms that are aggravated in AIRDs Several AIRDs exhibit increased overt cardiovascular disease (CVD) prevalence as well as findings of advanced subclinical atherosclerosis, which may precede the appearance of a clinical disease and thus be a target of early identification and preventive therapy Cells of the immune system can be found within atherosclerotic plaques, which suggests that they have a role in the atherogenic process Their migration and activation within the plaques can be secondary to various stimuli, including infectious agents3 These cells probably aggravate atherosclerosis, because CD4+ and CD8+ T-cell depletion reduced fatty streak formation in C57BL/6 mice In addition, after crossing of apolipoprotein E (ApoE)-knockout mice with immunodeficient scid/scid mice, the offspring had a 73% reduction in aortic fatty streak lesions compared with the immunocompetent apoE mice Moreover, when CD4+ T cells were transferred from the immunocompetent to the immunodeficient mice, they increased lesion area in the latter by 164%4 It is therefore not surprising that as in autoimmune diseases, the cellular components …

Sequential proton transfer through water bridges in acid-base reactions.

Abstract: The proton transfer mechanism between aqueous Bronsted acids and bases, forming an encounter pair, has been studied in real time with ultrafast infrared spectroscopy. The transient intermediacy of a hydrated proton, formed by ultrafast dissociation from an optically triggered photoacid proton donor ROH, is implicated by the appearance of an infrared absorption marker band before protonation of the base, B-. Thus, proton exchange between an acid and a base in aqueous solution is shown to proceed by a sequential, von Grotthuss-type, proton-hopping mechanism through water bridges. The spectra suggest a hydronium cation H3O+ structure for the intermediate, stabilized in the Eigen configuration in the ionic complex RO-...H3O+...B-.

Biodegradation of polyethylene by the thermophilic bacterium Brevibacillus borstelensis.

Abstract: D. HADAD, S. GERESH AND A. SIVAN. 2005. Aim: To select a polyethylene-degrading micro-organism and to study the factors affecting its biodegrading activity. Methods and Results: A thermophilic bacterium Brevibaccillus borstelensis strain 707 (isolated from soil) utilized branched low-density polyethylene as the sole carbon source and degraded it. Incubation of polyethylene with B. borstelensis (30 days, 50� C) reduced its gravimetric and molecular weights by 11 and 30% respectively. Brevibaccillus borstelensis also degraded polyethylene in the presence of mannitol. Biodegradation of u.v. photo-oxidized polyethylene increased with increasing irradiation time. Fourier Transform Infra-Red (FTIR) analysis of photooxidized polyethylene revealed a reduction in carbonyl groups after incubation with the bacteria. Conclusions: This study demonstrates that polyethylene – considered to be inert – can be biodegraded if the right microbial strain is isolated. Enrichment culture methods were effective for isolating a thermophilic bacterium capable of utilizing polyethylene as the sole carbon and energy source. Maximal biodegradation was obtained in combination with photo-oxidation, which showed that carbonyl residues formed by photo-oxidation play a role in biodegradation. Brevibaccillus borstelensis also degraded the CH2 backbone of nonirradiated polyethylene. Significance and Impact of the Study: Biodegradation of polyethylene by a single bacterial strain contributes to our understanding of the process and the factors affecting polyethylene biodegradation.

Nutrient-Specific Foraging in Invertebrate Predators

Abstract: Many herbivores and omnivores adjust their food selection behavior to regulate the intake of multiple nutrients. Carnivores, however, are generally assumed to optimize the rate of prey capture rather than select prey according to nutrient composition. We showed experimentally that invertebrate predators can forage selectively for protein and lipids to redress specific nutritional imbalances. This selection can take place at different stages of prey handling: The predator may select among foods of different nutritional composition, eat more of a prey if it is rich in nutrients that the predator is deficient in, or extract specific nutrients from a single prey item.

Should Science be Taught in Early Childhood

Abstract: This essay considers the question of why we should teach science to K-2. After initial consideration of two traditional reasons for studying science, six assertions supporting the idea that even small children should be exposed to science are given. These are, in order: (1) Children naturally enjoy observing and thinking about nature. (2) Exposing students to science develops positive attitudes towards science. (3) Early exposure to scientific phenomena leads to better understanding of the scientific concepts studied later in a formal way. (4) The use of scientifically informed language at an early age influences the eventual development of scientific concepts. (5) Children can understand scientific concepts and reason scientifically. (6) Science is an efficient means for developing scientific thinking. Concrete illustrations of some of the ideas discussed in this essay, particularly, how language and prior knowledge may influence the development of scientific concepts, are then provided. The essay concludes by emphasizing that there is a window of opportunity that educators should exploit by presenting science as part of the curriculum in both kindergarten and the first years of primary school.

Molecular mechanisms of cellular transformation by HTLV-1 Tax.

Abstract: The HTLV Tax protein is crucial for viral replication and for initiating malignant transformation leading to the development of adult T-cell leukemia. Tax has been shown to be oncogenic, since it transforms and immortalizes rodent fibroblasts and human T-lymphocytes. Through CREB, NF-kappaB and SRF pathways Tax transactivates cellular promoters including those of cytokines (IL-13, IL-15), cytokine receptors (IL-2Ralpha) and costimulatory surface receptors (OX40/OX40L) leading to upregulated protein expression and activated signaling cascades (e.g. Jak/STAT, PI3Kinase, JNK). Tax also stimulates cell growth by direct binding to cyclin-dependent kinase holenzymes and/or inactivating tumor suppressors (e.g. p53, DLG). Moreover, Tax silences cellular checkpoints, which guard against DNA structural damage and chromosomal missegregation, thereby favoring the manifestation of a mutator phenotype in cells.

The Burnout Measure, Short Version.

Abstract: The Burnout Measure (BM; Pines & Aronson, 1988) is a widely used self-report measure of burnout. It includes 21 items, evaluated on 7-point frequency scales, assessing the level of an individual's physical, emotional, and mental exhaustion. In this article, a shorter, 10-item version of the BM (BMS)

Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus.

Abstract: Human cytomegalovirus, a chief pathogen in immunocompromised people, can persist in a healthy immunocompetent host throughout life without being eliminated by the immune system. Here we show that pp65, the main tegument protein of human cytomegalovirus, inhibited natural killer cell cytotoxicity by an interaction with the activating receptor NKp30. This interaction was direct and specific, leading to dissociation of the linked CD3zeta from NKp30 and, consequently, to reduced killing. Thus, pp65 is a ligand for the NKp30 receptor and demonstrates a unique mechanism by which an intracellular viral protein causes general suppression of natural killer cell cytotoxicity by specific interaction with an activating receptor.

Kinetics of film formation by interfacial polycondensation.

Abstract: An approximate analytical model of film formation by interfacial polycondensation is presented. The analysis requires knowledge of a minimal set of certain kinetic parameters (monomer diffusivities and reaction rate constants) and reaction conditions (monomer concentrations and thickness of the unstirred layer). The process proceeds as a succession of two or three markedly different kinetic regimes. Each regime (insipient film formation, slowdown, and diffusion-limited growth) sets a different pattern of local polymer accumulation, with important implications for the structure of the emerging film. At the incipient stage, a loose polymer film begins to emerge in a fixed narrow region inside the boundary layer, followed by gradual densification of the middle part of the film. A condition for film formation is thus formulated on the basis of our analysis. The model predicts that two different scenarios are possible, which depend on the permeability of the polymer: films with a low permeability to both monomers pass through an abrupt slowdown of film growth, whereas permeable films undergo a smooth transition between the incipient film formation and diffusion-limited regimes. The model incorporates the highly important effects of the accumulation of reactive end groups and the decrease of monomer diffusion with the polymer concentration on the kinetics of the process and film characteristics. In addition, the validity of the utilized mean-field approach is analyzed, and the analysis suggests a direct correlation between the roughness and the thickness of the film. The results are in good agreement with an earlier numerical study and the direct structural studies of polyamide membrane films.

Self-assembled peptide nanotubes are uniquely rigid bioinspired supramolecular structures.

Abstract: We recently presented a novel class of self-assembled diphenylalanine-based peptide nanotubes. Here, for the first time, we present their mechanical properties, which we directly measured through indentation type experiments using atomic force microscopy. We find that the averaged point stiffness of the nanotubes is 160 N/m, and that they have a correspondingly high Young's modulus of ∼19 GPa, as calculated by finite element analysis. This high value places these peptide nanotubes among the stiffest biological materials presently known, making them attractive building blocks for the design and assembly of biocompatible nanodevices.

Proposed mechanisms for the induction of insulin resistance by oxidative stress.

Abstract: In diabetes (type 1 and type 2), increased flux of free fatty acids and glucose is associated with increased mitochondrial reactive oxygen species (ROS) production and, as a consequence, increased oxidative stress. ROS have been shown to activate various cellular stress-sensitive pathways, which can interfere with cellular signaling pathways. Exposure of different cell lines to micromolar concentrations of hydrogen peroxide leads to the activation of stress kinases such as c-Jun N-terminal kinase, p38, IκB kinase, and extracellular receptor kinase 1/2. This activation is accompanied by a down-regulation of the cellular response to insulin, leading to a reduced ability of insulin to promote glucose uptake, and glycogen and protein synthesis. The mechanisms leading to this down-regulation in oxidized cells are complicated, involving increased serine/threonine phosphorylation of insulin receptor substrate-1 (IRS1), impaired insulin-stimulated redistribution of IRS1 and phosphatidylinositol-kinase between cyt...

Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of pre-eclampsia.

Abstract: Objective: Accumulating evidence suggests that the balance between vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and their receptors is important for effective vasculogenesis, angiogenesis, and placental development. Recently, the soluble form of VEGFR-1 (sVEGFR-1), an antagonist to VEGF and PlGF, has been implicated in the pathophysiology of pre-eclampsia. Plasma sVEGFR-1 concentration is elevated in pre-eclampsia at the time of clinical diagnosis and correlates with the severity of the disease. The purpose of this study was to determine whether the concentrations of sVEGFR-1 in plasma of pre-eclamptic patients change prior to the clinical manifestations of the disease.Methods: A longitudinal case-control study was conducted in normal pregnant women (n = 44) and patients with pre-eclampsia (n = 44). Blood sampling was performed at six intervals: (1) 7–16 weeks; (2) 16–24 weeks; (3) 24–28 weeks; (4) 28–32 weeks; (5) 32–36 weeks; and (6) more than 37 weeks of gestation. To exam...

Deficiency of the ADP-forming succinyl-CoA synthase activity is associated with encephalomyopathy and mitochondrial DNA depletion.

Abstract: The mitochondrial DNA (mtDNA) depletion syndrome is a quantitative defect of mtDNA resulting from dysfunction of one of several nuclear-encoded factors responsible for maintenance of mitochondrial deoxyribonucleoside triphosphate (dNTP) pools or replication of mtDNA. Markedly decreased succinyl-CoA synthetase activity due to a deleterious mutation in SUCLA2, the gene encoding the β subunit of the ADP-forming succinyl-CoA synthetase ligase, was found in muscle mitochondria of patients with encephalomyopathy and mtDNA depletion. Succinyl-CoA synthetase is invariably in a complex with mitochondrial nucleotide diphosphate kinase; hence, we propose that a defect in the last step of mitochondrial dNTP salvage is a novel cause of the mtDNA depletion syndrome.

Identifying Performance Measures of Small Ventures-The Case of the Tourism Industry

Abstract: Drawing on the goal theory to effectiveness, the current research study attempts to identify performance measures of small ventures by focusing on the tourism industry and by doing so develops a conceptual model of small-venture performance in a service industry within its unique conditions. After reviewing theory and research on small venture performance measures in general and in service industries in particular, we propose that performance measures of small tourism ventures constitute a combination of short- and long-term measures. Furthermore, both types of measures include both objective and subjective dimensions. The findings, based on a cluster sample of 305 small tourism venture owner–managers that were interviewed face to face, generally supported the research proposition. The study emphasizes the importance of mapping the venture's achievements, allocating resources, and developing managerial skills to improve its performance and ability to survive in the long run.

On the Origins of the Task Mixing Cost in the Cuing Task-Switching Paradigm.

Abstract: Poorer performance in conditions involving task repetition within blocks of mixed tasks relative to task repetition within blocks of single task is called mixing cost (MC). In 2 experiments exploring 2 hypotheses regarding the origins of MC, participants either switched between cued shape and color tasks, or they performed them as single tasks. Experiment 1 supported the hypothesis that mixed-tasks trials require the resolution of task ambiguity by showing that MC existed only with ambiguous stimuli that afforded both tasks and not with unambiguous stimuli affording only 1 task. Experiment 2 failed to support the hypothesis that holding multiple task sets in working memory (WM) generates MC by showing that systematic manipulation of the number of stimulus-response rules in WM did not affect MC. The results emphasize the role of competition management between task sets during task control.

CD11b+/Gr-1+ Immature Myeloid Cells Mediate Suppression of T Cells in Mice Bearing Tumors of IL-1β-Secreting Cells

Abstract: Tumor cells secreting IL-1beta are invasive and metastatic, more than the parental line or control mock-transfected cells, and concomitantly induce in mice general immune suppression of T cell responses. Suppression strongly correlates with accumulation in the peripheral blood and spleen of CD11b+/Gr-1+ immature myeloid cells and hematological alterations, such as splenomegaly, leukocytosis, and anemia. Resection of large tumors of IL-1beta-secreting cells restored immune reactivity and hematological alterations within 7-10 days. Treatment of tumor-bearing mice with the physiological inhibitor of IL-1, the IL-1R antagonist, reduced tumor growth and attenuated the hematological alterations. Depletion of CD11b+/Gr-1+ immature myeloid cells from splenocytes of tumor-bearing mice abrogated suppression. Despite tumor-mediated suppression, resection of large tumors of IL-1beta-secreting cells, followed by a challenge with the wild-type parental cells, induced resistance in mice; protection was not observed in mice bearing tumors of mock-transfected fibrosarcoma cells. Altogether, we show in this study that tumor-derived IL-1beta, in addition to its proinflammatory effects on tumor invasiveness, induces in the host hematological alterations and tumor-mediated suppression. Furthermore, the antitumor effectiveness of the IL-1R antagonist was also shown to encompass restoration of hematological alterations, in addition to its favorable effects on tumor invasiveness and angiogenesis that have previously been described by us.

The voltage-dependent anion channel-1 modulates apoptotic cell death.

Abstract: The role of the voltage-dependent anion channel (VDAC) in cell death was investigated using the expression of native and mutated murine VDAC1 in U-937 cells and VDAC inhibitors. Glutamate 72 in VDAC1, shown previously to bind dicyclohexylcarbodiimide (DCCD), which inhibits hexokinase isoform I (HK-I) binding to mitochondria, was mutated to glutamine. Binding of HK-I to mitochondria expressing E72Q-mVDAC1, as compared to native VDAC1, was decreased by ∼70% and rendered insensitive to DCCD. HK-I and ruthenium red (RuR) reduced the VDAC1 conductance but not that of E72Q-mVDAC1. Overexpression of native or E72Q-mVDAC1 in U-937 cells induced apoptotic cell death (80%). RuR or overexpression of HK-I prevented this apoptosis in cells expressing native but not E72Q-mVDAC1. Thus, a single amino-acid mutation in VDAC prevented HK-I- or RuR-mediated protection against apoptosis, suggesting the direct VDAC regulation of the mitochondria-mediated apoptotic pathway and that the protective effects of RuR and HK-I rely on their binding to VDAC.

Sand dunes mobility and stability in relation to climate

Abstract: Sand dunes form an important and unique system that can be mobile or fixed by vegetation. The common mobility indices of sand dunes, which are related to the wind and the amount of precipitation and potential evaporation, do not work in many dune fields around the world. The reasons for that lie in the singular physical characteristics of the sandy soil. Sand has high hydraulic conductivity causing a high rate of infiltration of rain water to the groundwater. Sand particles lack cohesion and that makes wind erosion the main limiting factor for vegetation. Hence, wind power, manifested by the drift potential (DP), is a good index for the limiting factor of plants on sand. The physical–biological interaction is further developed by hysteresis, which shows that a dune can become vegetated when the wind power is sufficiently low. Once vegetated, a much higher wind stress is needed to destroy the vegetation and re-activate the dunes.