Showing papers by "Ben-Gurion University of the Negev published in 2011"

Introduction to Recommender Systems Handbook

Abstract: Recommender Systems (RSs) are software tools and techniques providing suggestions for items to be of use to a user. In this introductory chapter we briefly discuss basic RS ideas and concepts. Our main goal is to delineate, in a coherent and structured way, the chapters included in this handbook and to help the reader navigate the extremely rich and detailed content that the handbook offers.

Extraneous factors in judicial decisions

Abstract: Are judicial rulings based solely on laws and facts? Legal formalism holds that judges apply legal reasons to the facts of a case in a rational, mechanical, and deliberative manner. In contrast, legal realists argue that the rational application of legal reasons does not sufficiently explain the decisions of judges and that psychological, political, and social factors influence judicial rulings. We test the common caricature of realism that justice is “what the judge ate for breakfast” in sequential parole decisions made by experienced judges. We record the judges’ two daily food breaks, which result in segmenting the deliberations of the day into three distinct “decision sessions.” We find that the percentage of favorable rulings drops gradually from ≈65% to nearly zero within each decision session and returns abruptly to ≈65% after a break. Our findings suggest that judicial rulings can be swayed by extraneous variables that should have no bearing on legal decisions.

Vision-based hand-gesture applications

Abstract: Body posture and finger pointing are a natural modality for human-machine interaction, but first the system must know what it's seeing.

Secret-sharing schemes: a survey

Abstract: A secret-sharing scheme is a method by which a dealer distributes shares to parties such that only authorized subsets of parties can reconstruct the secret. Secret-sharing schemes are an important tool in cryptography and they are used as a building box in many secure protocols, e.g., general protocol for multiparty computation, Byzantine agreement, threshold cryptography, access control, attribute-based encryption, and generalized oblivious transfer. In this survey, we describe the most important constructions of secret-sharing schemes; in particular, we explain the connections between secret-sharing schemes and monotone formulae and monotone span programs. We then discuss the main problem with known secret-sharing schemes - the large share size, which is exponential in the number of parties. We conjecture that this is unavoidable. We present the known lower bounds on the share size. These lower bounds are fairly weak and there is a big gap between the lower and upper bounds. For linear secret-sharing schemes, which is a class of schemes based on linear algebra that contains most known schemes, super-polynomial lower bounds on the share size are known. We describe the proofs of these lower bounds. We also present two results connecting secret-sharing schemes for a Hamiltonian access structure to the NP vs. coNP problem and to a major open problem in cryptography - constructing oblivious-transfer protocols from one-way functions.

The Identification of Frailty:: A Systematic Literature Review

Abstract: An operational definition of frailty is important for clinical care, research, and policy planning. The literature on the clinical definitions, screening tools, and severity measures of frailty were systematically reviewed as part of the Canadian Initiative on Frailty and Aging. Searches of MEDLINE from 1997 to 2009 were conducted, and reference lists of retrieved articles were pearled, to identify articles published in English and French on the identification of frailty in community-dwelling people aged 65 and older. Two independent reviewers extracted descriptive information on study populations, frailty criteria, and outcomes from the selected papers, and quality rankings were assigned. Of 4,334 articles retrieved from the searches and 70 articles retrieved from the pearling, 22 met study inclusion criteria. In the 22 articles, physical function, gait speed, and cognition were the most commonly used identifying components of frailty, and death, disability, and institutionalization were common outcomes. The prevalence of frailty ranged from 5% to 58%. Despite significant work over the past decade, a clear consensus definition of frailty does not emerge from the literature. The definition and outcomes that best suit the unique needs of the researchers, clinicians, or policy-makers conducting the screening determine the choice of a screening tool for frailty. Important areas for further research include whether disability should be considered a component or an outcome of frailty. In addition, the role of cognitive and mood elements in the frailty construct requires further clarification.

The effect of light, salinity, and nitrogen availability on lipid production by Nannochloropsis sp.

Abstract: We examined responses of batch cultures of the marine microalga Nannochloropsis sp. to combined alterations in salinity (13, 27, and 40 g/l NaCl) and light intensity (170 and 700 μmol photons/m2·s). Major growth parameters and lipid productivity (based on total fatty acid determination) were determined in nitrogen-replete and nitrogen-depleted cultures of an initial biomass of 0.8 and 1.4 g/l, respectively. On the nitrogen-replete medium, increases in light intensity and salinity increased the cellular content of dry weight and lipids due to enhanced formation of triacylglycerols (TAG). Maximum average productivity of ca. 410 mg TFA/l/d were obtained at 700 μmol photons/m2·s and 40 g/l NaCl within 7 days. Under stressful conditions, content of the major LC-PUFA, eicosapentaenoic acid (EPA), was significantly reduced while TAG reached 25% of biomass. In contrast, lower salinity tended to improve major growth parameters, consistent with less variation in EPA contents. Combined higher salinity and light intensity was detrimental to lipid productivity under nitrogen starvation; biomass TFA content, and lipid productivity amounted for only 33% of DW and ca. 200 mg TFA/l/day, respectively. The highest biomass TFA content (ca. 47% DW) and average lipid productivity of ca. 360 mg TFA/l/day were achieved at 13 g/l NaCl and 700 μmol photons/m2·s. Our data further support selecting Nannochloropsis as promising microalgae for biodiesel production. Moreover, appropriate cultivation regimes may render Nannochloropsis microalgae to produce simultaneously major valuable components, EPA, and TAG, while sustaining relatively high biomass growth rates.

MAPPING JOURNALISM CULTURES ACROSS NATIONS: A comparative study of 18 countries

Abstract: This article reports key findings from a comparative survey of the role perceptions, epistemological orientations and ethical views of 1800 journalists from 18 countries. The results show that detachment, non-involvement, providing political information and monitoring the government are considered essential journalistic functions around the globe. Impartiality, the reliability and factualness of information, as well as adherence to universal ethical principles are also valued worldwide, though their perceived importance varies across countries. Various aspects of interventionism, objectivism and the importance of separating facts from opinion, on the other hand, seem to play out differently around the globe. Western journalists are generally less supportive of any active promotion of particular values, ideas and social change, and they adhere more to universal principles in their ethical decisions. Journalists from non-western contexts, on the other hand, tend to be more interventionist in their role perceptions and more flexible in their ethical views.

IL-1α and IL-1β Recruit Different Myeloid Cells and Promote Different Stages of Sterile Inflammation

Abstract: The immune system has evolved to protect the host from invading pathogens and to maintain tissue homeostasis. Although the inflammatory process involving pathogens is well documented, the intrinsic compounds that initiate sterile inflammation and how its progression is mediated are still not clear. Because tissue injury is usually associated with ischemia and the accompanied hypoxia, the microenvironment of various pathologies involves anaerobic metabolites and products of necrotic cells. In the current study, we assessed in a comparative manner the role of IL-1α and IL-1β in the initiation and propagation of sterile inflammation induced by products of hypoxic cells. We found that following hypoxia, the precursor form of IL-1α, and not IL-1β, is upregulated and subsequently released from dying cells. Using an inflammation-monitoring system consisting of Matrigel mixed with supernatants of hypoxic cells, we noted accumulation of IL-1α in the initial phase, which correlated with the infiltration of neutrophils, and the expression of IL-1β correlated with later migration of macrophages. In addition, we were able to show that IL-1 molecules from cells transfected with either precursor IL-1α or mature IL-1β can recruit neutrophils or macrophages, respectively. Taken together, these data suggest that IL-1α, released from dying cells, initiates sterile inflammation by inducing recruitment of neutrophils, whereas IL-1β promotes the recruitment and retention of macrophages. Overall, our data provide new insight into the biology of IL-1 molecules as well as on the regulation of sterile inflammation.

General properties of transcriptional time series in Escherichia coli

Abstract: Gene activity is described by the time series of discrete, stochastic mRNA production events. This transcriptional time series shows intermittent, bursty behavior. One consequence of this temporal intricacy is that gene expression can be tuned by varying different features of the time series. Here we quantify copy-number statistics of mRNA from 20 Escherichia coli promoters using single-molecule fluorescence in situ hybridization in order to characterize the general properties of these transcriptional time series. We find that the degree of burstiness is correlated with gene expression level but is largely independent of other parameters of gene regulation. The observed behavior can be explained by the underlying variation in the duration of bursting events. Using Shannon's mutual information function, we estimate the mutual information transmitted between an outside stimulus, such as the extracellular concentration of inducer molecules, and intracellular levels of mRNA. This suggests that the outside stimulus transmits information reflected in the properties of transcriptional time series.

Sensitivity‐enhancement methods for surface plasmon sensors

Abstract: Surface plasmon resonance (SPR) sensors have been a mature technology for more than two decades now, however, recent investigations show continuous enhancement of their sensitivity and their lower detection limit. Together with the recent investigations in localized SPR phenomena, extraordinary optical transmission through nanoapertures in metals, and surface-enhanced spectroscopies, drastic developments are expected to revolutionize the field of optical biosensing. Sensitivity-enhancement (SE) techniques are reviewed focusing both on the physical transduction mechanisms and the system performance. In the majority of cases the SE is associated with the enhancement of the electromagnetic field overlap integral describing the interaction energy within the analyte. Other important mechanisms are the interaction between plasmons and excitons and between the analyte molecules and the metal surface. The lower detection limit can be reduced significantly if systems with high signal-to-noise ratio are used such as common-path interferometry, ellipsometry or polarimetry systems.

The influence of trees and grass on outdoor thermal comfort in a hot-arid environment

Abstract: The effects of vegetation on human thermal stress in a hot-arid region were tested in two semi-enclosed urban spaces with various combinations of mature trees, grass, overhead shading mesh and paving. The index of thermal stress was calculated hourly from measured meteorological data in the studied sites to evaluate thermal comfort in the different spaces based on radiative and convective pedestrian–environment energy exchanges and sweat efficiency, and expressed on a thermal sensation scale ranging from ‘comfortable’ to ‘very hot’. The efficiency of water use in providing improved comfort was gauged for each of the vegetative landscaping treatments by comparing the total evapotranspiration with the reduction in thermal stress, both expressed in terms of their values in equivalent energy. While conditions in a paved, unshaded courtyard were found to be uncomfortable throughout the daytime hours (with half of these hours defined by severe discomfort), each of the landscape treatments made a clear contribution to improved thermal comfort. With shading, either by trees or mesh, discomfort was reduced in duration by over half and limited in maximum severity when the shading was placed above paving. When combined with grass, both shading mechanisms yielded comfortable conditions at all hours. In both cases, the effect of trees was more pronounced than that of the mesh, but by a small margin. With unshaded grass, ‘hot’ conditions in the courtyard were restricted to a short period in mid-afternoon, a considerable improvement over unshaded paving, attributable mainly to the lower radiant surface temperatures. Copyright © 2010 Royal Meteorological Society

Development of a transformation system for Chlamydia trachomatis: restoration of glycogen biosynthesis by acquisition of a plasmid shuttle vector.

Abstract: Chlamydia trachomatis remains one of the few major human pathogens for which there is no transformation system. C. trachomatis has a unique obligate intracellular developmental cycle. The extracellular infectious elementary body (EB) is an infectious, electron-dense structure that, following host cell infection, differentiates into a non-infectious replicative form known as a reticulate body (RB). Host cells infected by C. trachomatis that are treated with penicillin are not lysed because this antibiotic prevents the maturation of RBs into EBs. Instead the RBs fail to divide although DNA replication continues. We have exploited these observations to develop a transformation protocol based on expression of β-lactamase that utilizes rescue from the penicillin-induced phenotype. We constructed a vector which carries both the chlamydial endogenous plasmid and an E.coli plasmid origin of replication so that it can shuttle between these two bacterial recipients. The vector, when introduced into C. trachomatis L2 under selection conditions, cures the endogenous chlamydial plasmid. We have shown that foreign promoters operate in vivo in C. trachomatis and that active β-lactamase and chloramphenicol acetyl transferase are expressed. To demonstrate the technology we have isolated chlamydial transformants that express the green fluorescent protein (GFP). As proof of principle, we have shown that manipulation of chlamydial biochemistry is possible by transformation of a plasmid-free C. trachomatis recipient strain. The acquisition of the plasmid restores the ability of the plasmid-free C. trachomatis to synthesise and accumulate glycogen within inclusions. These findings pave the way for a comprehensive genetic study on chlamydial gene function that has hitherto not been possible. Application of this technology avoids the use of therapeutic antibiotics and therefore the procedures do not require high level containment and will allow the analysis of genome function by complementation.

Principals' leadership and teachers' motivation: Self‐determination theory analysis

Abstract: Purpose – The purpose of this paper is to investigate the relationship between educational leadership and teacher's motivation. The research described here was anchored in the convergence of two fundamental theories of leadership and motivation: the full range model of leadership and self‐determination theory. The central hypotheses were that transformational leadership would predict autonomous motivation among teachers, whereas transactional leadership would predict controlled motivation. The authors further predicted that autonomous motivation would mediate the relations between transformational leadership and teachers' burnout and that controlled motivation would mediate the relations between transactional leadership and burnout.Design/methodology/approach – Questionnaires assessing the variables of interest were completed by 122 Israeli teachers.Findings – Results, based on structure equation modeling, supported the hypotheses, suggesting that leadership styles among school principals play a significa...

LifeFlow: visualizing an overview of event sequences

Abstract: Event sequence analysis is an important task in many domains: medical researchers may study the patterns of transfers within the hospital for quality control; transportation experts may study accident response logs to identify best practices. In many cases they deal with thousands of records. While previous research has focused on searching and browsing, overview tasks are often overlooked. We introduce a novel interactive visual overview of event sequences called \emph{LifeFlow}. LifeFlow is scalable, can summarize all possible sequences, and represents the temporal spacing of the events within sequences. Two case studies with healthcare and transportation domain experts are presented to illustrate the usefulness of LifeFlow. A user study with ten participants confirmed that after 15 minutes of training novice users were able to rapidly answer questions about the prevalence and temporal characteristics of sequences, find anomalies, and gain significant insight from the data.

Modulation of cardiac macrophages by phosphatidylserine-presenting liposomes improves infarct repair

Abstract: Herein we investigated a new strategy for the modulation of cardiac macrophages to a reparative state, at a predetermined time after myocardial infarction (MI), in aim to promote resolution of inflammation and elicit infarct repair. The strategy employed intravenous injections of phosphatidylserine (PS)-presenting liposomes, mimicking the anti-inflammatory effects of apoptotic cells. Following PS-liposome uptake by macrophages in vitro and in vivo, the cells secreted high levels of anti-inflammatory cytokines [transforming growth factor β (TGFβ) and interleukin 10 (IL-10)] and upregulated the expression of the mannose receptor—CD206, concomitant with downregulation of proinflammatory markers, such as tumor necrosis factor α (TNFα) and the surface marker CD86. In a rat model of acute MI, targeting of PS-presenting liposomes to infarct macrophages after injection via the femoral vein was demonstrated by magnetic resonance imaging (MRI). The treatment promoted angiogenesis, the preservation of small scars, and prevented ventricular dilatation and remodeling. This strategy represents a unique and accessible approach for myocardial infarct repair.

PW-MAC: An energy-efficient predictive-wakeup MAC protocol for wireless sensor networks

Abstract: This paper presents PW-MAC (Predictive-Wakeup MAC), a new energy-efficient MAC protocol based on asynchronous duty cycling. In PW-MAC, nodes each wake up to receive at randomized, asynchronous times. PW-MAC minimizes sensor node energy consumption by enabling senders to predict receiver wakeup times; to enable accurate predictions, PW-MAC introduces an on-demand prediction error correction mechanism that effectively addresses timing challenges such as unpredictable hardware and operating system delays and clock drift. PW-MAC also introduces an efficient prediction-based retransmission mechanism to achieve high energy efficiency even when wireless collisions occur and packets must be retransmitted. We evaluate PW-MAC on a testbed of MICAz motes and compare it to X-MAC, WiseMAC, and RI-MAC, three previous energy-efficient MAC protocols, under multiple concurrent multihop traffic flows and under hidden-terminal scenarios and scenarios in which nodes have wakeup schedule conflicts. In all experiments, PW-MAC significantly outperformed these other protocols. For example, evaluated on scenarios with 15 concurrent transceivers in the network, the average sender duty cycle for X-MAC, WiseMAC, and RI-MAC were all over 66%, while PW-MAC's average sender duty cycle was only 11%; the delivery latency for PW-MAC in these scenarios was less than 5% that for WiseMAC and X-MAC. In all experiments, PW-MAC maintained a delivery ratio of 100%.

The persistent exclusion of older patients from ongoing clinical trials regarding heart failure.

Abstract: Methods: In the context of the Increasing the PaRticipation of the ElDerly in Clinical Trials (PREDICT) study, data from ongoing clinical trials regarding heart failure were extracted from the World Health Organization Clinical Trials Registry Platform on December 1, 2008. Main outcome measures were the proportion of trials excluding patients by an arbitrary upper age limit or by other exclusion criteria that might indirectly cause limited recruitment of older individuals. We classified exclusion criteria into 2 categories: justified or poorly justified. Results: Among 251 trials investigating treatments for heart failure, 64 (25.5%) excluded patients by an arbitrary upper age limit. Such exclusion was significantly more common in trials conducted in the European Union than in the United States (31/96 [32.3%] vs 17/105 [16.2%];P=.007) and in drug trials sponsored by public institutions vs those by private entities (21/59 [35.6%] vs 5/36 [13.9%];P=.02). Overall, 109 trials (43.4%) on heart failure had 1 or more poorly justified exclusion criteria that could limit the inclusion of older individuals. A similar proportion of clinical trials with poorly justified exclusion criteria was found in pharmacologic and nonpharmacologic trials. Conclusion: Despite the recommendations of national and international regulatory agencies, exclusion of older individuals from ongoing trials regarding heart failure continues to be widespread.

Biomechanical energy harvesting from human motion: theory, state of the art, design guidelines, and future directions

Abstract: Biomechanical energy harvesting from human motion presents a promising clean alternative to electrical power supplied by batteries for portable electronic devices and for computerized and motorized prosthetics. We present the theory of energy harvesting from the human body and describe the amount of energy that can be harvested from body heat and from motions of various parts of the body during walking, such as heel strike; ankle, knee, hip, shoulder, and elbow joint motion; and center of mass vertical motion. We evaluated major motions performed during walking and identified the amount of work the body expends and the portion of recoverable energy. During walking, there are phases of the motion at the joints where muscles act as brakes and energy is lost to the surroundings. During those phases of motion, the required braking force or torque can be replaced by an electrical generator, allowing energy to be harvested at the cost of only minimal additional effort. The amount of energy that can be harvested was estimated experimentally and from literature data. Recommendations for future directions are made on the basis of our results in combination with a review of state-of-the-art biomechanical energy harvesting devices and energy conversion methods. For a device that uses center of mass motion, the maximum amount of energy that can be harvested is approximately 1 W per kilogram of device weight. For a person weighing 80 kg and walking at approximately 4 km/h, the power generation from the heel strike is approximately 2 W. For a joint-mounted device based on generative braking, the joints generating the most power are the knees (34 W) and the ankles (20 W). Our theoretical calculations align well with current device performance data. Our results suggest that the most energy can be harvested from the lower limb joints, but to do so efficiently, an innovative and light-weight mechanical design is needed. We also compared the option of carrying batteries to the metabolic cost of harvesting the energy, and examined the advantages of methods for conversion of mechanical energy into electrical energy.

Economic Games on the Internet: The Effect of $1 Stakes

Abstract: Online labor markets such as Amazon Mechanical Turk (MTurk) off er an unprecedented opportunity to run economic game experiments quickly and inexpensively. Using Mturk, we recruited 756 subjects and examined their behavior in four canonical economic games, with two payoff conditions each: a stakes condition, in which subjects' earnings were based on the outcome of the game (maximum earnings of $1); and a no-stakes condition, in which subjects' earnings are una ffected by the outcome of the game. Our results demonstrate that economic game experiments run on MTurk are comparable to those run in laboratory settings, even when using very low stakes.

Literal and Metaphorical Sense Identification through Concrete and Abstract Context

Abstract: Metaphor is ubiquitous in text, even in highly technical text. Correct inference about textual entailment requires computers to distinguish the literal and metaphorical senses of a word. Past work has treated this problem as a classical word sense disambiguation task. In this paper, we take a new approach, based on research in cognitive linguistics that views metaphor as a method for transferring knowledge from a familiar, well-understood, or concrete domain to an unfamiliar, less understood, or more abstract domain. This view leads to the hypothesis that metaphorical word usage is correlated with the degree of abstractness of the word's context. We introduce an algorithm that uses this hypothesis to classify a word sense in a given context as either literal (denotative) or metaphorical (connotative). We evaluate this algorithm with a set of adjective-noun phrases (e.g., in dark comedy, the adjective dark is used metaphorically; in dark hair, it is used literally) and with the TroFi (Trope Finder) Example Base of literal and nonliteral usage for fifty verbs. We achieve state-of-the-art performance on both datasets.

GlobFit: consistently fitting primitives by discovering global relations

Abstract: Given a noisy and incomplete point set, we introduce a method that simultaneously recovers a set of locally fitted primitives along with their global mutual relations. We operate under the assumption that the data corresponds to a man-made engineering object consisting of basic primitives, possibly repeated and globally aligned under common relations. We introduce an algorithm to directly couple the local and global aspects of the problem. The local fit of the model is determined by how well the inferred model agrees to the observed data, while the global relations are iteratively learned and enforced through a constrained optimization. Starting with a set of initial RANSAC based locally fitted primitives, relations across the primitives such as orientation, placement, and equality are progressively learned and conformed to. In each stage, a set of feasible relations are extracted among the candidate relations, and then aligned to, while best fitting to the input data. The global coupling corrects the primitives obtained in the local RANSAC stage, and brings them to precise global alignment. We test the robustness of our algorithm on a range of synthesized and scanned data, with varying amounts of noise, outliers, and non-uniform sampling, and validate the results against ground truth, where available.