Showing papers by "Ben-Gurion University of the Negev published in 2014"

The autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism

Abstract: Autism spectrum disorders (ASDs) represent a formidable challenge for psychiatry and neuroscience because of their high prevalence, lifelong nature, complexity and substantial heterogeneity. Facing these obstacles requires large-scale multidisciplinary efforts. Although the field of genetics has pioneered data sharing for these reasons, neuroimaging had not kept pace. In response, we introduce the Autism Brain Imaging Data Exchange (ABIDE)-a grassroots consortium aggregating and openly sharing 1112 existing resting-state functional magnetic resonance imaging (R-fMRI) data sets with corresponding structural MRI and phenotypic information from 539 individuals with ASDs and 573 age-matched typical controls (TCs; 7-64 years) (http://fcon_1000.projects.nitrc.org/indi/abide/). Here, we present this resource and demonstrate its suitability for advancing knowledge of ASD neurobiology based on analyses of 360 male subjects with ASDs and 403 male age-matched TCs. We focused on whole-brain intrinsic functional connectivity and also survey a range of voxel-wise measures of intrinsic functional brain architecture. Whole-brain analyses reconciled seemingly disparate themes of both hypo- and hyperconnectivity in the ASD literature; both were detected, although hypoconnectivity dominated, particularly for corticocortical and interhemispheric functional connectivity. Exploratory analyses using an array of regional metrics of intrinsic brain function converged on common loci of dysfunction in ASDs (mid- and posterior insula and posterior cingulate cortex), and highlighted less commonly explored regions such as the thalamus. The survey of the ABIDE R-fMRI data sets provides unprecedented demonstrations of both replication and novel discovery. By pooling multiple international data sets, ABIDE is expected to accelerate the pace of discovery setting the stage for the next generation of ASD studies.

Increasing CO2 threatens human nutrition.

Abstract: experiments contribute more than tenfold more data regarding both the zinc and iron content of the edible portions of crops grown under FACE conditions than is currently available in the literature. Consistent with earlier meta-analyses of other aspects of plant function under FACE conditions 14,15 , we considered the response comparisons observed from different species, cultivars and stress treatments and from different years to be independent. The natural logarithm of the mean response ratio (r5 response in elevated [CO2]/response in ambient [CO2]) was used as the metric for all analyses. Meta-analysis was used to estimate the overall effect of elevated [CO2] on the concentration of each nutrient in a particular crop and to determine the significance of this effect (see Methods). We found that elevated [CO2] was associated with significant decreases in the concentrations of zinc and iron in all C3 grasses and legumes (Fig. 1 and Extended Data Table 1). For example, wheat grains grown at elevated [CO2] had 9.3% lower zinc (95% confidence interval (CI)212.7% to25.9%) and 5.1% lower iron (95% CI26.5% to23.7%) than those grown at ambient [CO2]. We also found that elevated [CO2] was associated with lower protein content in C3 grasses, with a 6.3% decrease (95% CI27.5% to25.2%) in wheat grains and a 7.8% decrease (95% CI 28.9% to26.8%) in rice grains. Elevated [CO2] was associated with a small decrease in protein in field peas, and there was no significant

Summary of the ASK14 Ground Motion Relation for Active Crustal Regions

Abstract: Empirical ground motion models for the average horizontal component from shallow crustal earthquakes in active tectonic regions are derived using the PEER NGA-West2 database. The model is applicabl...

Decision Making in Health and Medicine: Integrating Evidence and Values

Abstract: Preface 1 Elements of decision making in health care 2 Managing uncertainty 3 Choosing the best treatment 4 Valuing outcomes 5 Interpreting diagnostic information 6 Deciding when to test 7 Multiple test results 8 Finding and summarizing the evidence 9 Constrained resources 10 Recurring events 11 Variability and uncertainty 12 Proactive decision making: a way of life Index

Fouling and cleaning of ultrafiltration membranes: A review

Abstract: Ultrafiltration (UF) is one of the best options for both one-stage and as part of multi-stage water and wastewater purification. This review summarises the known facts about the fouling processes and cleaning procedures and details of the most successful physical and chemical cleaning combinations. The optimum cleaning is closely linked to the nature of the fouling. Precise knowledge of both the fouling type (organic, inorganic, or biological) and the fouling mechanism (gel formation, adsorption, deposition, pore blockage, or cake formation) is the key to success in UF membrane cleaning.

Quality-space theory in olfaction

Abstract: Quality-space theory (QST) explains the nature of the mental qualities distinctive of perceptual states by appeal to their role in perceiving. QST is typically described in terms of the mental qualities that pertain to color. Here we apply QST to the olfactory modalities. Olfaction is in various respects more complex than vision, and so provides a useful test case for QST. To determine whether QST can deal with the challenges olfaction presents, we show how a quality space (QS) could be constructed relying on olfactory perceptible properties and the olfactory mental qualities then defined by appeal to that QS of olfactory perceptible properties. We also consider how to delimit the olfactory QS from other modalities. We further apply QST to the role that experience plays in refining our olfactory discriminative abilities and the occurrence of olfactory mental qualities in non-conscious olfactory states. QST is shown to be fully applicable to and useful for understanding the complex domain of olfaction.

Mutant Adenosine Deaminase 2 in a Polyarteritis Nodosa Vasculopathy

Abstract: BACKGROUND Polyarteritis nodosa is a systemic necrotizing vasculitis with a pathogenesis that is poorly understood. We identified six families with multiple cases of systemic and cutaneous polyarteritis nodosa, consistent with autosomal recessive inheritance. In most cases, onset of the disease occurred during childhood. METHODS We carried out exome sequencing in persons from multiply affected families of Georgian Jewish or German ancestry. We performed targeted sequencing in additional family members and in unrelated affected persons, 3 of Georgian Jewish ancestry and 14 of Turkish ancestry. Mutations were assessed by testing their effect on enzymatic activity in serum specimens from patients, analysis of protein structure, expression in mammalian cells, and bio physical analysis of purified protein. RESULTS In all the families, vasculitis was caused by recessive mutations in CECR1, the gene encoding adenosine deaminase 2 (ADA2). All the Georgian Jewish patients were homozygous for a mutation encoding a Gly47Arg substitution, the German patients were compound heterozygous for Arg169Gln and Pro251Leu mutations, and one Turkish patient was compound heterozygous for Gly47Val and Trp264Ser mutations. In the endogamous Georgian Jewish population, the Gly47Arg carrier frequency was 0.102, which is consistent with the high prevalence of disease. The other mutations either were found in only one family member or patient or were extremely rare. ADA2 activity was significantly reduced in serum specimens from patients. Expression in human embryonic kidney 293T cells revealed low amounts of mutant secreted protein. CONCLUSIONS Recessive loss-of-function mutations of ADA2, a growth factor that is the major extracellular adenosine deaminase, can cause polyarteritis nodosa vasculopathy with highly varied clinical expression. (Funded by the Shaare Zedek Medical Center and others.)

Harvesting Robots for High-value Crops: State-of-the-art Review and Challenges Ahead

Abstract: This review article analyzes state-of-the-art and future perspectives for harvesting robots in high-value crops. The objectives were to characterize the crop environment relevant for robotic harvesting, to perform a literature review on the state-of-the-art of harvesting robots using quantitative measures, and to reflect on the crop environment and literature review to formulate challenges and directions for future research and development. Harvesting robots were reviewed regarding the crop harvested in a production environment, performance indicators, design process techniques used, hardware design decisions, and algorithm characteristics. On average, localization success was 85%, detachment success was 75%, harvest success was 66%, fruit damage was 5%, peduncle damage was 45%, and cycle time was 33 s. A kiwi harvesting robot achieved the shortest cycle time of 1 s. Moreover, the performance of harvesting robots did not improve in the past three decades, and none of these 50 robots was commercialized. Four future challenges with R&D directions were identified to realize a positive trend in performance and to successfully implement harvesting robots in practice: 1 simplifying the task, 2 enhancing the robot, 3 defining requirements and measuring performance, and 4 considering additional requirements for successful implementation. This review article may provide new directions for future automation projects in high-value crops.

A model for fast extragalactic radio bursts

Abstract: Bursts of millisecond duration were recently discovered in the 1 GHz band. There is a strong evidence that they come from $\sim 1 $ Gpc distances, which implies extraordinary high brightness temperature. I propose that these bursts could be attributed to synchrotron maser emission from relativistic, magnetized shocks. At the onset of the magnetar flare, a strongly magnetized pulse is formed, which propagates away through the relativistic magnetar wind and eventually reaches the nebula inflated by the wind within the surrounding medium. I show that the observed radio bursts could be generated at shocks formed via the interaction of the magnetic pulse with the plasma within the nebula. The model predicts strong millisecond bursts in the TeV band, which could be observed even from distant galaxies.

Classification of current anticancer immunotherapies

Abstract: During the past decades, anticancer immunotherapy has evolved from a promising therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now approved by the US Food and Drug Administration and the European Medicines Agency for use in cancer patients, and many others are being investigated as standalone therapeutic interventions or combined with conventional treatments in clinical studies. Immunotherapies may be subdivided into "passive" and "active" based on their ability to engage the host immune system against cancer. Since the anticancer activity of most passive immunotherapeutics (including tumor-targeting monoclonal antibodies) also relies on the host immune system, this classification does not properly reflect the complexity of the drug-host-tumor interaction. Alternatively, anticancer immunotherapeutics can be classified according to their antigen specificity. While some immunotherapies specifically target one (or a few) defined tumor-associated antigen(s), others operate in a relatively non-specific manner and boost natural or therapy-elicited anticancer immune responses of unknown and often broad specificity. Here, we propose a critical, integrated classification of anticancer immunotherapies and discuss the clinical relevance of these approaches.

East–West gradient in the incidence of inflammatory bowel disease in Europe: the ECCO-EpiCom inception cohort

Abstract: Objective: The incidence of inflammatory bowel disease (IBD) is increasing in Eastern Europe. The reasons for these changes remain unknown. The aim of this study was to investigate whether an East– ...

State of the Art in Surface Reconstruction from Point Clouds

Abstract: The area of surface reconstruction has seen substantial progress in the past two decades. The traditional problem addressed by surface reconstruction is to recover the digital representation of a physical shape that has been scanned, where the scanned data contains a wide variety of defects. While much of the earlier work has been focused on reconstructing a piece-wise smooth representation of the original shape, recent work has taken on more specialized priors to address significantly challenging data imperfections, where the reconstruction can take on different representations -- not necessarily the explicit geometry. This state-of-the-art report surveys the field of surface reconstruction, providing a categorization with respect to priors, data imperfections, and reconstruction output. By considering a holistic view of surface reconstruction, this report provides a detailed characterization of the field, highlights similarities between diverse reconstruction techniques, and provides directions for future work in surface reconstruction.

Cucurbit[7]uril⋅guest pair with an attomolar dissociation constant

Abstract: Host⋅guest complexes between cucurbit[7] (CB[7]) or CB[8] and diamantane diammonium ion guests 3 or 6 were studied by 1H NMR spectroscopy and X-ray crystallography. 1H NMR competition experiments revealed that CB[7]⋅6 is among the tightest monovalent non-covalent complexes ever reported in water with Ka=7.2×1017 M−1 in pure D2O and 1.9×1015 M−1 in D2O buffered with NaO2CCD3 (50 mM). The crystal structure of CB[7]⋅6 allowed us to identify some of the structural features responsible for the ultratight binding, including the distance between the NMe3+ groups of 6 (7.78 A), which allows it to establish 14 optimal ion-dipole interactions with CB[7], the complementarity of the convex van der Waals surface contours of 6 with the corresponding concave surfaces of CB[7], desolvation of the CO portals within the CB[7]⋅6 complex, and the co-linearity of the C7 axis of CB[7] with the N+⋅⋅⋅N+ line in 6. This work further blurs the lines of distinction between natural and synthetic receptors.

Derivation of land surface temperature for Landsat-8 TIRS using a split window algorithm.

Abstract: Land surface temperature (LST) is one of the most important variables measured by satellite remote sensing. Public domain data are available from the newly operational Landsat-8 Thermal Infrared Sensor (TIRS). This paper presents an adjustment of the split window algorithm (SWA) for TIRS that uses atmospheric transmittance and land surface emissivity (LSE) as inputs. Various alternatives for estimating these SWA inputs are reviewed, and a sensitivity analysis of the SWA to misestimating the input parameters is performed. The accuracy of the current development was assessed using simulated Modtran data. The root mean square error (RMSE) of the simulated LST was calculated as 0.93 °C. This SWA development is leading to progress in the determination of LST by Landsat-8 TIRS.

Origin of the high performance in GeTe-based thermoelectric materials upon Bi2Te3 doping.

Abstract: As a lead-free material, GeTe has drawn growing attention in thermoelectrics, and a figure of merit (ZT) close to unity was previously obtained via traditional doping/alloying, largely through hole carrier concentration tuning. In this report, we show that a remarkably high ZT of ∼1.9 can be achieved at 773 K in Ge0.87Pb0.13Te upon the introduction of 3 mol % Bi2Te3. Bismuth telluride promotes the solubility of PbTe in the GeTe matrix, thus leading to a significantly reduced thermal conductivity. At the same time, it enhances the thermopower by activating a much higher fraction of charge transport from the highly degenerate Σ valence band, as evidenced by density functional theory calculations. These mechanisms are incorporated and discussed in a three-band (L + Σ + C) model and are found to explain the experimental results well. Analysis of the detailed microstructure (including rhombohedral twin structures) in Ge0.87Pb0.13Te + 3 mol % Bi2Te3 was carried out using transmission electron microscopy and crystallographic group theory. The complex microstructure explains the reduced lattice thermal conductivity and electrical conductivity as well.

Green synthesis of gold nanoparticles using plant extracts as reducing agents

Abstract: Gold nanoparticles (GNPs) were prepared using four different plant extracts as reducing and stabilizing agents The extracts were obtained from the following plants: Salvia officinalis, Lippia citriodora, Pelargonium graveolens and Punica granatum The size distributions of the GNPs were measured using three different methods: dynamic light scattering, nanoparticle-tracking analysis and analysis of scanning electron microscopy images The three methods yielded similar size distributions Biocompatibility was examined by correlation of L-cell growth in the presence of different amounts of GNPs All GNPs showed good biocompatibility and good stability for over 3 weeks Therefore, they can be used for imaging and drug-delivery applications in the human body High-resolution transmission electron microscopy was used to view the shapes of the larger GNPs, while infrared spectroscopy was employed to characterize the various functional groups in the organic layer that stabilize the particles Finally, active ingredients in the plant extract that might be involved in the formation of GNPs are proposed, based on experiments with pure antioxidants that are known to exist in that plant

Build-to-last: strength to weight 3D printed objects

Abstract: The emergence of low-cost 3D printers steers the investigation of new geometric problems that control the quality of the fabricated object. In this paper, we present a method to reduce the material cost and weight of a given object while providing a durable printed model that is resistant to impact and external forces. We introduce a hollowing optimization algorithm based on the concept of honeycomb-cells structure. Honeycombs structures are known to be of minimal material cost while providing strength in tension. We utilize the Voronoi diagram to compute irregular honeycomb-like volume tessellations which define the inner structure. We formulate our problem as a strength--to--weight optimization and cast it as mutually finding an optimal interior tessellation and its maximal hollowing subject to relieve the interior stress. Thus, our system allows to build-to-last 3D printed objects with large control over their strength-to-weight ratio and easily model various interior structures. We demonstrate our method on a collection of 3D objects from different categories. Furthermore, we evaluate our method by printing our hollowed models and measure their stress and weights.

Incidence of gastroenteropancreatic neuroendocrine tumours: a systematic review of the literature

Abstract: Based on the current medical literature, the worldwide incidence of neuroendocrine tumours (NETs) seems to have increased; however, a systematic literature overview is lacking. This study aimed to collect all available data on the incidence of gastroenteropancreatic (GEP)-NETs and characteristics of population to establish their epidemiology. A sensitive MEDLINE search was carried out. The papers were selected via a cascade process that restricted the initial pool of 7991 articles to 33, using predefined inclusion and exclusion criteria. Original articles evaluating the incidence of sporadic GEP-NETs in regional, institutional and national registries were considered. The majority of data originated from the US National Cancer Institute Surveillance, Epidemiology and End Results database and from national cancer registries in Western Europe. Generally, because of the retrospective nature of existing databases the outcomes of studies might be biased, which hinders the drawing of firm conclusions. The age-adjusted incidence of GEP-NETs has increased steadily over the past four decades (1973-2007), increasing 3.65-fold in the USA and 3.8- to 4.8-fold in the UK. Incidence has changed variably from one anatomical site to another. The greatest increase in incidence occurred for gastric and rectal NETs, while the smallest increase occurred for small intestine NETs. There were gender and racial differences, which differed site by site and, in some cases, changed over time. The incidence rates (IRs) of GEP-NETs have increased significantly in the last 40 years. Data are only available from North America, Western Europe and Japan. A site-by-site analysis revealed that the IRs of some NETs increased more than those of others.

Effect of high-albedo materials on pedestrian heat stress in urban street canyons

Abstract: Extensive use of high-albedo materials has been advocated as a means of mitigating the urban heat island, especially in warm-climate cities. The implicit assumptions of this strategy are that by lowering canopy layer air temperature, cities will enjoy (a) reduced air conditioning loads in buildings and (b) improved thermal comfort for pedestrians in outdoor urban spaces. The second of these assumptions is examined here by means of computer modeling, in a two-stage approach whereby thermal comfort (represented by the Index of Thermal Stress) is calculated using detailed microclimatic input data simulated by a canyon model (CAT). The analysis suggests that although use of high-albedo materials in canyon surfaces may lower air temperature, the reduction is not enough to offset increased radiant loads. As a result, pedestrian thermal comfort may in fact be compromised.

A comparative investigation of seven indirect attitude measures

Abstract: We compared the psychometric qualities of seven indirect attitude measures across three attitude domains (race, politics, and self-esteem) with a large sample (N = 23,413). We compared the measures on internal consistency, sensitivity to known effects, relationships with indirect and direct measures of the same topic, the reliability and validity of single-category attitude measurement, their ability to detect meaningful variance among people with nonextreme attitudes, and their robustness to the exclusion of misbehaving or well-behaving participants. All seven indirect measures correlated with each other and with direct measures of the same topic. These relations were always weak for self-esteem, moderate for race, and strong for politics. This pattern suggests that some of the sources of variation in the reliability and predictive validity of the indirect measures is a function of the concepts rather than the methods. The Implicit Association Test (IAT) and Brief IAT (BIAT) showed the best overall psychometric quality, followed by the Go–No-Go association task, Single-Target IAT (ST-IAT), Affective Misattribution Procedure (AMP), Sorting Paired Features task, and Evaluative Priming. The AMP showed a steep decline in its psychometric qualities when people with extreme attitude scores were removed. Single-category attitude scores computed for the IAT and BIAT showed good relationships with other attitude measures but no evidence of discriminant validity between paired categories. The other measures, especially the AMP and ST-IAT, showed better evidence for discriminant validity. These results inform us on the validity of the measures as attitude assessments, but do not speak to the implicitness of the measured constructs.

Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure.

Abstract: Adrenergic stimulation of brown adipocytes (BA) induces mitochondrial uncoupling, thereby increasing energy expenditure by shifting nutrient oxidation towards thermogenesis Here we describe that mitochondrial dynamics is a physiological regulator of adrenergically-induced changes in energy expenditure The sympathetic neurotransmitter Norepinephrine (NE) induced complete and rapid mitochondrial fragmentation in BA, characterized by Drp1 phosphorylation and Opa1 cleavage Mechanistically, NE-mediated Drp1 phosphorylation was dependent on Protein Kinase-A (PKA) activity, whereas Opa1 cleavage required mitochondrial depolarization mediated by FFAs released as a result of lipolysis This change in mitochondrial architecture was observed both in primary cultures and brown adipose tissue from cold-exposed mice Mitochondrial uncoupling induced by NE in brown adipocytes was reduced by inhibition of mitochondrial fission through transient Drp1 DN overexpression Furthermore, forced mitochondrial fragmentation in BA through Mfn2 knock down increased the capacity of exogenous FFAs to increase energy expenditure These results suggest that, in addition to its ability to stimulate lipolysis, NE induces energy expenditure in BA by promoting mitochondrial fragmentation Together these data reveal that adrenergically-induced changes to mitochondrial dynamics are required for BA thermogenic activation and for the control of energy expenditure

Individual and Contextual Correlates of Trust in Media Across 44 Countries

Abstract: Media research demonstrates that audience trust in the news media is a highly consequential factor, shaping audience selection of and response to media, and potentially impacting citizens’ perceptions of the political system at large. Still, our knowledge about the correlates of trust in media is limited. Only a few studies have utilized a correlational design to explore the associations between trust in media and other factors, and almost all of these studies originate in the U.S. context. The current investigation utilizes data from 44 diverse countries (n = 57,847), collected as part of the World Values Survey, to broaden our understanding of trust in media. The aim is two-fold—to learn about individual-level correlates across contexts and to demonstrate that macro-level factors play a part in shaping such trust. Our findings indicate that levels of political interest, interpersonal trust, and exposure to television news and newspapers are positively correlated with trust in media, while education and ...