Institution
Ben-Gurion University of the Negev
Education•Beersheba, Israel•
About: Ben-Gurion University of the Negev is a education organization based out in Beersheba, Israel. It is known for research contribution in the topics: Population & Poison control. The organization has 24300 authors who have published 60851 publications receiving 1484608 citations. The organization is also known as: Universitat Ben Gurion Banegev & Universiṭat Ben-Guryon ba-Negev.
Topics: Population, Poison control, Pregnancy, Magnetic field, Health care
Papers published on a yearly basis
Papers
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University of Ottawa1, Health Science University2, University of York3, University of Warwick4, Abu Dhabi Indian School5, Ottawa Hospital Research Institute6, Ben-Gurion University of the Negev7, Tufts Medical Center8, University of Buenos Aires9, University of Glasgow10, Research Triangle Park11, Brigham and Women's Hospital12
TL;DR: The Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement is an attempt to consolidate and update previous health economic evaluation guidelines into one current, useful reporting guidance and it is hoped that this guidance will lead to more consistent and transparent reporting, and ultimately, better health decisions.
1,563 citations
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TL;DR: It is shown that dNK cells, but not peripheral blood–derived NK subsets, regulate trophoblast invasion both in vitro and in vivo by production of the interleukin-8 and interferon-inducible protein–10 chemokines.
Abstract: Human CD56(bright) NK cells accumulate in the maternal decidua during pregnancy and are found in direct contact with fetal trophoblasts. Several mechanisms have been proposed to explain the inability of NK cells to kill the semiallogeneic fetal cells. However, the actual functions of decidual NK (dNK) cells during pregnancy are mostly unknown. Here we show that dNK cells, but not peripheral blood-derived NK subsets, regulate trophoblast invasion both in vitro and in vivo by production of the interleukin-8 and interferon-inducible protein-10 chemokines. Furthermore, dNK cells are potent secretors of an array of angiogenic factors and induce vascular growth in the decidua. Notably, such functions are regulated by specific interactions between dNK-activating and dNK-inhibitory receptors and their ligands, uniquely expressed at the fetal-maternal interface. The overall results support a 'peaceful' model for reproductive immunology, in which elements of innate immunity have been incorporated in a constructive manner to support reproductive tissue development.
1,489 citations
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TL;DR: The Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement as mentioned in this paper is an attempt to consolidate and update previous health economic evaluation guidelines efforts into one current, useful reporting guidance.
Abstract: Economic evaluations of health interventions pose a particular challenge for reporting. There is also a need to consolidate and update existing guidelines and promote their use in a user friendly manner. The Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement is an attempt to consolidate and update previous health economic evaluation guidelines efforts into one current, useful reporting guidance. The primary audiences for the CHEERS statement are researchers reporting economic evaluations and the editors and peer reviewers assessing them for publication. The need for new reporting guidance was identified by a survey of medical editors. A list of possible items based on a systematic review was created. A two round, modified Delphi panel consisting of representatives from academia, clinical practice, industry, government, and the editorial community was conducted. Out of 44 candidate items, 24 items and accompanying recommendations were developed. The recommendations are contained in a user friendly, 24 item checklist. A copy of the statement, accompanying checklist, and this report can be found on the ISPOR Health Economic Evaluations Publication Guidelines Task Force website (www.ispor.org/TaskForces/ EconomicPubGuidelines.asp). We hope CHEERS will lead to better reporting, and ultimately, better health decisions. To facilitate dissemination and uptake, the CHEERS statement is being co-published across 10 health economics and medical journals. We encourage other journals and groups, to endorse CHEERS. The author team plans to review the checklist for an update in five years.
1,454 citations
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TL;DR: This work provides the first replicated association between a specific genetic locus involved in neuro-transmission and a normal personality trait, the 7 repeat allele in the locus for the D4 dopamine receptor gene (D4DR).
Abstract: Human personality traits which can be reliably measured by any of a number of rating scales, show a considerable heritable component1,2 The tridimensional personality questionnaire (TPQ) is one such instrument and was designed by Cloninger to measure four distinct domains of temperament — Novelty Seeking, Harm Avoidance, Reward Dependence and Persistence — that are hypothesized to be based on distinct neurochemical and genetic substrates Cloninger proposed that individual variations in the Novelty Seeking trait are mediated by genetic variability in dopamine transmission2 Individuals who score higher than average on the TPQ Novelty Seeking scale are characterized as impulsive, exploratory, fickle, excitable, quick-tempered and extravagant, whereas those who score lower than average tend to be reflective, rigid, loyal, stoic, slow-tempered and frugal We now show that higher than average Novelty Seeking test scores in a group of 124 unrelated Israeli subjects are significantly associated with a particular exonic polymorphism, the 7 repeat allele in the locus for the D4 dopamine receptor gene (D4DR) The association of high Novelty Seeking and the 7-repeat allele was independent of ethnicity, sex or age of the subjects This work, together with the accompanying confirmations in this issue3, provides the first replicated association between a specific genetic locus involved in neuro-transmission and a normal personality trait
1,439 citations
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TL;DR: The different firing properties of neurons in neocortex contribute significantly to its network behavior, particularly in response to current steps.
1,422 citations
Authors
Showing all 24557 results
Name | H-index | Papers | Citations |
---|---|---|---|
Robert Langer | 281 | 2324 | 326306 |
Meir J. Stampfer | 277 | 1414 | 283776 |
Charles A. Dinarello | 190 | 1058 | 139668 |
Joel Schwartz | 183 | 1149 | 109985 |
David L. Kaplan | 177 | 1944 | 146082 |
Menachem Elimelech | 157 | 547 | 95285 |
Roberto Romero | 151 | 1516 | 108321 |
Ernst Detlef Schulze | 133 | 670 | 69504 |
Chi-Huey Wong | 129 | 1220 | 66349 |
Gideon Koren | 129 | 1994 | 81718 |
Gerardo Heiss | 128 | 623 | 69393 |
Jacob N. Israelachvili | 126 | 520 | 79786 |
Gordana Vunjak-Novakovic | 125 | 483 | 45354 |
James H. Brown | 125 | 423 | 72040 |
Yehuda Shoenfeld | 125 | 1629 | 77195 |