Institution
Bethesda Hospital
Healthcare•Ambur, Tamil Nadu, India•
About: Bethesda Hospital is a healthcare organization based out in Ambur, Tamil Nadu, India. It is known for research contribution in the topics: Population & Helicobacter pylori. The organization has 386 authors who have published 472 publications receiving 15193 citations.
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors evaluated the efficacy of doxycycline to treat suspected COVID-19 respiratory symptoms in the community among people at high risk of adverse outcomes, and found that there was little evidence of difference in median time to first self-reported recovery between the usual care plus DO group and usual care only group (9·6 [95% Bayesian Credible Interval [BCI] 8·3 to 11·0] days vs 10·1 [8·7 to 11 · 7·7] days, hazard ratio 1·04
42 citations
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42 citations
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TL;DR: In this article, the authors compared the procedural discourse skills of a group of 26 TBI speakers, with those of two demographically distinct control groups: orthopaedic patients and university students.
Abstract: Procedural discourse is a monologue discourse task concerned with explaining to a listener how a particular activity is carried out The study reported here is part of a series of investigations into discourse abilities following severe traumatic brain injury (TBI) The aim of this study was to compare the procedural discourse skills of a group of 26 TBI speakers, with those of two demographically distinct control groups The first control group comprised 26 non-TBI orthopaedic patients, and the second control group comprised 26 university students These control groups were selected because of the hypothesis that premorbid demographic factors could influence sociolinguistic skills, and hence performance on a procedural discourse task The TBI group was systematically compared with the control groups on content, productivity, and pragmatic measures They were not significantly different from orthopaedic patients on measures relating to content and productivity; however, they did differ significan
42 citations
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TL;DR: The results confirmed the high expression of 17-1A cases of in colorectal carcinoma and revealed a high difference between paraffin and frozen sections, revealing a specific immunotherapy with MAbs against 17- 1A antigen in minimal residual stages of breast cancer might be considered.
Abstract: Substantial progress has been made in detecting cell surface or intracytoplasmatic antigens to identify spread tumor cells with monoclonal antibodies (MAbs). The 17-1A antigen is already used as a target for specific immunotherapy in colorectal cancer. The purpose of this study was to compare the expression of 17-1A antigen in colorectal tumors versus breast cancers. MAb against the epithelial-specific antigen (ESA) and a routine staining technique were used to detect the 17-1A antigen in 100 cases of colorectal and 111 cases of breast cancer. The antigen expression of each tumor entity was examined by light microscopy on paraffin sections. Thirty six of the formalin-fixed paraffin sections of breast cancer were compared with their corresponding frozen sections. Evaluation was realized by a histological score (grade 0-9) considering the distribution and the staining intensity. We found an antigen expression of 17-1A in colorectal cancer quantified at 7.1+/-1.8 and at 4.5+/-2.5 for breast cancer in our score. Comparing paraffin sections and frozen sections in the 36 cases of breast cancer, the score was 5.5+/-2.3 in the paraffin and 8.1+/-1.9 in the frozen section group. Our results confirmed the high expression of 17-1A cases of in colorectal carcinoma. Furthermore, 17-1A is expressed in the majority of breast carcinomas, revealing a high difference between paraffin and frozen sections. As a result, a specific immunotherapy with MAbs against 17-1A antigen in minimal residual stages of breast cancer might be considered.
42 citations
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TL;DR: Using appropriate energy parameters, the CO2 laser provides a safe, efficient microsurgical tool for performing stapedotomy simply and with minimum inner ear trauma.
Abstract: This clinical study was preceded by two laboratory experiments. The first experiment compared temperature changes in the vestibule while vaporizing a 0.6-mm stapedotomy with Argon, KTP-532, and CO2 lasers. Data demonstrated that the CO2 laser possesses superior tissue characteristics for stapedotomy. In the second experiment safe energy parameters were established for various Sharplan CO2 laser models. Using these safe power settings, 153 consecutive CO2 laser stapedotomies were performed under local anesthesia. No patient experienced intraoperative dizziness during or immediately following the application of the CO2 laser to the stapes footplate. Long-term postoperative hearing results demonstrated that 87% of the patients maintained an air/bone gap to within 10 dB and 94% maintained an air/bone gap to within 15 dB (mean follow-up 32 months). No patient incurred a significant sensorineural hearing loss (greater than 10 dB) in the speech range. Four patients developed a perilymph fistula (three immediate and one delayed) and fluctuating sensorineural hearing loss, but all were successfully repaired without significant permanent nerve deafness. At 4,000 Hz, five patients lost 20 dB and two patients dropped 40 dB compared with preoperative levels. Postoperative complications included four perilymph fistulas, two prostheses displaced from the stapedotomy opening, one fixed prosthesis, and one fixed incus. Seven of eight of these complications were successfully revised. At the time of this writing, 6/153 patients have a persistent conductive hearing loss greater than 20 dB and have not been revised. Using appropriate energy parameters, the CO2 laser provides a safe, efficient microsurgical tool for performing stapedotomy simply and with minimum inner ear trauma.
42 citations
Authors
Showing all 387 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jennie Ponsford | 73 | 393 | 18379 |
Peter J. Stern | 53 | 235 | 8622 |
Roger Hart | 46 | 154 | 7065 |
Glynda J. Kinsella | 40 | 120 | 5752 |
Jacinta Douglas | 39 | 180 | 4737 |
Gabriela Möslein | 36 | 112 | 6057 |
Pamela Claire Snow | 36 | 142 | 4496 |
Michael Denkinger | 34 | 147 | 3214 |
Thomas Daikeler | 30 | 141 | 3309 |
John Olver | 25 | 103 | 3189 |
J. C. Thijs | 24 | 46 | 2194 |
Daniel Navot | 24 | 56 | 2705 |
Bernd Sanner | 23 | 102 | 2652 |
Ulrike Nitz | 22 | 98 | 4068 |
Dries Testelmans | 22 | 92 | 2100 |