Bethesda Hospital

About: Bethesda Hospital is a healthcare organization based out in Ambur, Tamil Nadu, India. It is known for research contribution in the topics: Population & Helicobacter pylori. The organization has 386 authors who have published 472 publications receiving 15193 citations.

Medical rehabilitation system for patients in acute rehabilitation units

Abstract: 전 세계적으로 양질의 재활을 필요로 하는 모든 사람들에 게 최대한 제공될 수 있도록 재활이 강화되어야 하며 이러 한 재활 강화에 대한 요구는 기본적인 인권일 뿐 아니라 건 강을 증진시키고 사회, 경제에도 긍정적인 이익을 가져다 줄 수 있다[1,2]. 재활은 조기퇴원을 촉진할 수 있고 불필요한 재입원을 막고[3,4] 가정 복귀해서 생활할 수 있도록 해준다 [5-7]. 즉, 재활은 장애를 가지고 있거나 장애에 이를 가능 성이 높은 사람들을 대상으로 처한 환경에서 최적의 기능상 태에 도달할 수 있도록 지원하는 수단이므로 재활의료는 보 건의료시스템의 특정 단계에서만 공급되도록 하는 것이 아 니라 급성기(초기재활), 회복기(집중재활), 만성기(유지재활) 의 각각에서 다른 의료 부문과 통합적으로 공급되어야 한다 [2,8]. 각 시기별로 제공되는 재활의료서비스의 내용, 인력, 시설에서 차이가 있을 수 있으며 발병시기와 중증도에 따라 적합한 재활의료서비스를 제공받을 수 있도록 재활의료전달 체계의 구축이 중요하나 국내의 재활의료전달체계는 아직 국내 급성기 재활의료 공급체계

Effects of Bag Mask Ventilation and Advanced Airway Management on Adherence to Ventilation Recommendations and Chest Compression Fraction: A Prospective Randomized Simulator-Based Trial.

Abstract: The role of advanced airway management (AAM) in cardiopulmonary resuscitation (CPR) is currently debated as observational studies reported better outcomes after bag-mask ventilation (BMV), and the only prospective randomized trial was inconclusive. Adherence to CPR guidelines ventilation recommendations is unknown and difficult to assess in clinical trials. This study compared AAM and BMV with regard to adherence to ventilation recommendations and chest compression fractions in simulated cardiac arrests. A total of 154 teams of 3-4 physicians were randomized to perform CPR with resuscitation equipment restricting airway management to BMV only or equipment allowing for all forms of AAM. BMV teams ventilated 6 ± 6/min and AAM teams 19 ± 8/min (range 3-42/min; p < 0.0001 vs. BMV). 68/78 BMV teams and 23/71 AAM teams adhered to the ventilation recommendations (p < 0.0001). BMV teams had lower compression fractions than AAM teams (78 ± 7% vs. 86 ± 6%, p < 0.0001) resulting entirely from higher no-flow times for ventilation (9 ± 4% vs. 3 ± 3 %; p < 0.0001). Compared to BMV, AAM leads to significant hyperventilation and lower adherence to ventilation recommendations but favourable compression fractions. The cumulative effect of deviations from ventilation recommendations has the potential to blur findings in clinical trials.

Discontinuation of metformin in Type 2 Diabetes patients treated with Insulin

Abstract: Metformin added to insulin therapy in type 2 diabetic patients improves glycaemic control and decreases the required daily dose of insulin (DDI). Metformin should be discontinued if cardiac, hepatic or renal failure develops. We examined whether glycaemic control can be maintained after metformin cessation. We included 45 type 2 diabetic patients treated with insulin plus metformin, and 45 matched controls treated with insulin only. During 12 weeks we assessed glycaemic control every two weeks and, if necessary, adjusted the insulin dosage. Results: In the group in which metformin was discontinued, DDI increased from 67.9 ± 22.9 to 92.2 ± 29.4 IU (p<0.00I) leaving glycaemic control unchanged. In type 2 diabetic patients treated with insulin plus metformin, glycaemic control can be maintained after discontinuation of metformin by increasing the DDI substantially (20 to 36%) during application of an intensified treatment protocol.

Synostosis of the sacroiliac joint as a developmental variant, or ankylosis due to sacroiliitis?

Abstract: opment and progression. J Pathol 2008;216:131–40. 41. Mohammad HS, Kurokohchi K, Yoneyama H, Tokuda M, Morishita A, Jian G, et al. Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma. Int J Oncol 2008;33:1157–63. 42. Zhao P, Zhang W, Wang SJ, Yu XL, Tang J, Huang W, et al. HAb18G/CD147 promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in hepatocellular carcinoma cells. Hepatology 2011;54:2012–24. 43. Diaz VM, Hurtado M, Thomson TM, Reventos J, Paciucci R. Specific interaction of tissue-type plasminogen activator (t-PA) with annexin II on the membrane of pancreatic cancer cells activates plasminogen and promotes invasion in vitro. Gut 2004;53:993–1000. 44. Sharma MR, Rothman V, Tuszynski GP, Sharma MC. Antibodydirected targeting of angiostatin’s receptor annexin II inhibits Lewis Lung Carcinoma tumor growth via blocking of plasminogen activation: possible biochemical mechanism of angiostatin’s action. Exp Mol Pathol 2006;81:136–45. 45. Sharma MC, Sharma M. The role of annexin II in angiogenesis and tumor progression: a potential therapeutic target. Curr Pharm Des 2007;13:3568–75.

Sturge-Weber syndrome: clinical and radiological correlates in 86 patients.

Abstract: BACKGROUNDS AND PURPOSE To correlate the extent of the leptomeningeal angiomatosis with clinical features in Sturge-Weber syndrome (SWS) METHODS The study group consisted of 86 consecutive patients aged two months to 56 (mean 79 +/- 103) years with SWS and epilepsy Clinical and MRI data were analyzed RESULTS Based on the extent of leptomeningeal angiomatosis, patients were divided into two subgroups: 43 patients had hemispheric angiomatosis and atrophy, whereas, another 43 had focal involvement Nine of the 43 hemispherial patients (10%) showed bilateral involvement: all of these bilateral cases demonstrated dominance in a single side with hemispheric leptomeningeal angiomatosis and contralateral focal extension Hemispheric and focal subgroups were clinically different Patients with hemispheric SWS were younger at the age of epilepsy onset (p < 0001) and age at MRI examination (p < 005) Neither gender, lateralization, duration of epilepsy, appearance of secondarily generalized seizures, nor seizure frequency revealed a significant difference between subgroups CONCLUSION Bilateral involvement is frequent and occurs in cases with a hemisperic involvement on one side The age of epilepsy onset is related to the extent of leptomeningeal angiomatosis Patients with hemispheric form of SWS presented with earlier age of seizure onset Focal pial angiomatoses do not tend to progress (a longer duration is not associated with more frequent hemispheric involvement) Other variables including seizure frequency and secondary generalized tonic-clonic seizures are not associated with the extent of angiomatosis