Bethesda Hospital

About: Bethesda Hospital is a healthcare organization based out in Ambur, Tamil Nadu, India. It is known for research contribution in the topics: Population & Helicobacter pylori. The organization has 386 authors who have published 472 publications receiving 15193 citations.

Genetically determined neuromuscular disorders of some Roma families living in Hungary.

Abstract: The authors discuss the clinical and molecular genetic aspects of genetically determined neuromuscular disorders of some Roma families living in Hungary. Among the autosomal recessively inherited spinal muscular atrophic (SMA) group, 8 Caucasian children had the typical 7-8 exonal deletions of the SMA gene, but only 2 patients belonged to the Roma population. There was no difference in the molecular genetic findings among the Caucasian and the Roma SMA patients. All of them had 7-8 exonal deletions of the SMA gene. We wanted to call attention to the founder mutation of the Roma population in 7 patients suffering from congenital myasthenia (CMS) from 3 Roma families. The 1267G deletion for CMS was detected by molecular genetic method. Clinical onset was pubertal and relatively slow progression of specific and phenotypic features for this founder mutation of acetyl-cholin receptor epsylon gene. In 2 patients (sister and brother) the sarcoglycanopathy 2C type C283Q mutation was proven in one Roma family suffering from limb-girdle muscular dystrophy (LGMD). Two out of the three facioscapular-humeral dystrophy (FSHD) Roma families carried 21.8 kb and 18.5 kb alleles in FSHD A1 gene (D4S139). In one family together with prenatal diagnosis founder mutation in FSHD A1 gene was detected, according to the autosomal dominant (AD) inheritance. In (F2) prenatal diagnosis was carried out, 18.5 kb/18.5 kb homozygosity was proven in the fetus, so the pregnancy was interrupted. In the CMS, LGMD and FSHD Roma patients ancient typical Roma founder mutations were found.

The Effect of Different Types of Resting Hand Splints on Spasticity and Hand Function among Patients with Stroke

Abstract: After stroke, these changes consequently result in the limitation of upper limb joint range of motion or muscle shortening, and spasticity, causing the reduction of hand functions. This study aimed to investigate the effect according to the types of resting hand splints, particularly the effect of the application of resting hand splint. This study was performed in two groups, which were determined by random assignment according to the order of visits of 52 subjects who were diagnosed of stroke. The patients were divided into a dorsal resting hand splint group (n=26) and volar resting hand splint group (n=26). The data collected in this study was analyzed using SPSS version 18.0.For the difference in Modified Ashworth Scales (MAS), surface ElectroMyoGraphy (sEMG), and Wrist Active Range of Motion(AROM) before and after the intervention in two groups, paired t-test was performed, and independent sample t-test was performed to compare the change(s) before and after the intervention in two groups. Statistical significance level was α=.05. First, there was a significant difference in wrist MAS, AROM, and sEMG in the group of dorsal resting hand splint. Second, there was no significant difference in wrist MAS and AROM in the group of volar resting hand splint, but there was a significant difference in wrist sEMG. Third, there was a significant difference in wrist MAS and AROM in the group of resting dorsal hand splint as a result of comparing change(s) between two groups, but there was no significant difference in wrist sEMG. Through this study, it was found that dorsal resting hand splint was more effective in the reduction of wrist spasticity and improving AROM than volar resting hand splint in stroke patients. Applying resting hand splint to stroke patients would not only have preventive effects but also have great influence on the improvement of hand function.

The extremely rare vascular variant of a segmental duplicated uterine artery and its relevance for the interventionist and gynecologist: a case report.

Abstract: Anatomic variants of the uterine artery are rare, with the absence of one of the uterine arteries presumably being the most abundant variant. A duplicated uterine artery is mentioned in the medical literature, but to the best of our knowledge, an angiographic study has never been published. A partially duplicated uterine artery is an extremely rare variant not previously mentioned in the literature, and it could lead to technical difficulties or cause problems in various gynecological interventions. We present the case of a 45-year-old Caucasian woman with a uterine fibroid and typical fibroid-related symptoms who came to our department to get treated with fibroid embolization. During the procedure, angiography revealed a partial or segmental duplicated left uterine artery. This exceptionally rare anatomic variant proved to be beneficial for the safety of the embolization in our case; however, it is far more likely that such a variant would be unfavorable in some types of gynecological operative and minimally invasive techniques. Knowledge of the anatomic variant of a partially duplicated uterine artery is important, especially for gynecologists performing minimally invasive surgical procedures.

Major Bleed Post Minimally Invasive Surgical Repair of Inguinal Hernia

Abstract: At our center, over 200 patients undergo minimally invasive repairs of inguinal hernias every year using a laparoscope and a robotic-assisted technique. In three patients who underwent a minimally invasive procedure for uncomplicated indirect inguinal hernia, the postoperative course was complicated with bleeding and required an exploratory laparotomy. Post-procedure, the patients developed tachycardia and hypotension with a drop in hemoglobin, for which the patients required surgical re-exploration in an emergent fashion. The factors leading to bleeding were analyzed and are reported herein to increase awareness and prevent the occurrence of these complications during inguinal hernia surgery.