Bharathiar University

About: Bharathiar University is a education organization based out in Coimbatore, Tamil Nadu, India. It is known for research contribution in the topics: Thin film & Adsorption. The organization has 5812 authors who have published 8628 publications receiving 143934 citations. The organization is also known as: BU.

PEG functionalized selenium nanoparticles as a carrier of crocin to achieve anticancer synergism

Abstract: Selenium nanoparticles (SeNPs) have garnered a great deal of attention as potential cancer therapeutic payloads. However, the in vivo targeting drug delivery has been challenging. Herein, we describe the synthesis of PEG functionalized SeNPs (PEG-SeNPs) and its use as a cancer-targeted delivery vehicle to achieve enhanced anticancer efficacy. Crocin, a major active product of saffron (dried stigmas of Crocus sativus), having many therapeutic properties was conjugated to PEG-SeNPs. PEG-SeNPs showed pH-mediated crocin release for potential cancer therapy. Crocin conjugated PEG-SeNPs exhibits unprecedented enhanced cytotoxicity toward lung cancer cells through induction of apoptosis. Furthermore, crocin conjugated PEG-SeNPs significantly inhibited in vivo tumor growth in nude mice model. This cancer-targeted design of SeNPs opens a new path for synergistic treating of cancer with higher efficacy and decreased side effects.

Fe(2+) binding on amyloid β-peptide promotes aggregation.

Abstract: The metal ions Zn(2+) , Cu(2+) , and Fe(2+) play a significant role in the aggregation mechanism of Aβ peptides. However, the nature of binding between metal and peptide has remained elusive; the detailed information on this from the experimental study is very difficult. Density functional theory (dft) (M06-2X/6-311++G (2df,2pd) +LANL2DZ) has employed to determine the force field resulting due to metal and histidine interaction. We performed 200 ns molecular dynamics (MD) simulation on Aβ1-42 -Zn(2+) , Aβ1-42 -Cu(2+) , and Aβ1-42 -Fe(2+) systems in explicit water with different combination of coordinating residues including the three Histidine residues in the N-terminal. The present investigation, the Aβ1-42 -Zn(2+) system possess three turn conformations separated by coil structure. Zn(2+) binding caused the loss of the helical structure of N-terminal residues which transformed into the S-shaped conformation. Zn(2+) has reduced the coil and increases the turn content of the peptide compared with experimental study. On the other hand, the Cu(2+) binds with peptide, β sheet formation is observed at the N-terminal residues of the peptide. Fe(2+) binding is to promote the formation of Glu22-Lys28 salt-bridge which stabilized the turn conformation in the Phe19-Gly25 residues, subsequently β sheets were observed at His13-Lys18 and Gly29-Gly37 residues. The turn conformation facilitates the β sheets are arranged in parallel by enhancing the hydrophobic contact between Gly25 and Met35, Lys16 and Met35, Leu17 and Leu34, Val18 and Leu34 residues. The Fe(2+) binding reduced the helix structure and increases the β sheet content in the peptide, which suggested, Fe(2+) promotes the oligomerization by enhancing the peptide-peptide interaction. Proteins 2016; 84:1257-1274. © 2016 Wiley Periodicals, Inc.

Surfactant-Assisted BaTiO3:Eu3+@SiO2 Core–Shell Superstructures Obtained by Ultrasonication Method: Dormant Fingerprint Visualization and Red Component of White Light-Emitting Diode Applications

Abstract: Nanoparticles (NPs) synthesized via a facile sonochemical route showed excellent assembly of BaTiO3:Eu3+@SiO2 superstructures (SS) using CTAB as a surfactant. Crystallite size, phase, surface science, and core–shell confirmation were determined through advanced characterization techniques. Experimental parameters like pH, temperature, and surfactant concentration were varied and resulted in SS with high surface modifications, and the possible mechanisms for the same are reported. Scanning electron microscopy images revealed broomlike structures, and various experimental parameters resulting in them dissolving into freestanding sticks are discussed. CIE chromaticity coordinates were in the range of the orange-red to pure red. Drawbacks associated with the commercial powder dusting method for visualizing dormant fingerprint (DFP), namely, high background scattering and high autofluorescence of the substrate material, were improved with the help of the prepared SS as a dusting powder. Visualization of DFPs a...