BIA Separations (Slovenia)

About: BIA Separations (Slovenia) is a company organization based out in Ljubljana, Slovenia. It is known for research contribution in the topics: Monolithic HPLC column & Monolith. The organization has 84 authors who have published 152 publications receiving 4883 citations.

Use of Differential Scanning Calorimetry and Immunoaffinity Chromatography to Identify Disease Induced Changes in Human Blood Plasma Proteome.

Abstract: Differential scanning calorimetry provides unique signatures of blood plasma samples Plasma samples from diseased individuals yield specific thermograms, which differ from each other and from plasma samples of healthy individuals Thermograms from individuals suffering from chronic lymphocytic leukemia, multiple myeloma and acute myeloid leukemia were measured with DSC To obtain additional information about thermal behaviour of plasma proteins immunoaffinity chromatography was introduced An immunoextraction of HSA using a chromatographic column with immobilized anti-HSA was carried out in order to enrich less abundant plasma proteins, which could provide a further insight into disease development Efficiency of HSA depletion and protein composition of fractionated plasma was validated by SDS-PAGE

Use of Convective Interaction Media for Analysis of Long‐Nosed Viper Venom

Abstract: It was confirmed in this study that Vipera ammodytes ammodytes venom samples with a higher content of ammodytoxins (Atxs), basic neurotoxic phospholipases A2, are more lethal, exposing Atxs as one of the major toxic components in the long‐nosed viper venom. In addition, we recently correlated the ability of the venom to produce highly protective antiserum in rabbits with the amount of Atxs in the venom. Here, we developed a rapid, robust, and highly reproducible chromatographic method, based on HPLC separation on Convective Interaction Media to assess the quantity of Atxs in a particular venom sample in order to predict its potential to induce highly protective antiserum in immunized animals.

Process and device for the rapid separation and/or conversion of substrates

Abstract: A process for the conversion of substrates both for analytical and preparative purposes in a flow-through and cross-flow reactor having compact porous discs and/or compact porous tubes as carrier for conversion reaction or preparative separations which compact porous discs and/or compact porous tubes are modified with substances being capable of specifically binding and/or converting said substrates by distributing the samples to be converted and/or preparatively separated and collecting the converted and/or separated substrates preferably in a low volume, wherein the distribution of the sample does not affect the carrier adversely.