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Institution

Bialystok University of Technology

EducationBiałystok, Poland
About: Bialystok University of Technology is a education organization based out in Białystok, Poland. It is known for research contribution in the topics: Linear system & Fractional calculus. The organization has 1757 authors who have published 5421 publications receiving 37487 citations. The organization is also known as: Politechnika Białostocka.


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Book ChapterDOI
01 Jan 2015

3,828 citations

Journal ArticleDOI
TL;DR: The main group of enzymes responsible for the collagen and other protein degradation in extracellular matrix (ECM) are matrix metalloproteinases (MMPs), and MMPs and their inhibitors have multiple biological functions in all stages of cancer development.
Abstract: The main group of enzymes responsible for the collagen and other protein degradation in extracellular matrix (ECM) are matrix metalloproteinases (MMPs). Collagen is the main structural component of connective tissue and its degradation is a very important process in the development, morphogenesis, tissue remodeling, and repair. Typical structure of MMPs consists of several distinct domains. MMP family can be divided into six groups: collagenases, gelatinases, stromelysins, matrilysins, membrane-type MMPs, and other non-classified MMPs. MMPs and their inhibitors have multiple biological functions in all stages of cancer development: from initiation to outgrowth of clinically relevant metastases and likewise in apoptosis and angiogenesis. MMPs and their inhibitors are extensively examined as potential anticancer drugs. MMP inhibitors can be divided into two main groups: synthetic and natural inhibitors. Selected synthetic inhibitors are in clinical trials on humans, e.g. synthetic peptides, non-peptidic molecules, chemically modified tetracyclines, and bisphosphonates. Natural MMP inhibitors are mainly isoflavonoids and shark cartilage.

645 citations

Journal ArticleDOI
TL;DR: A method that uses Noisy-OR gates to reduce the data requirements in learning conditional probabilities in Bayesian networks is proposed and tested on a model for diagnosis of liver disorders, whose parameters are extracted from a real, small set of patient records.

290 citations

Journal ArticleDOI
TL;DR: This work discusses a problem of synthesis of robust terms, i.e., descriptions of information granules, satisfying a given specification, an important problem for granular computing and its applications for spatial reasoning or knowledge discovery and data mining.
Abstract: We introduce basic notions related to granular computing, namely the information granule syntax and semantics as well as the inclusion and closeness (similarity) relations of granules. Different information sources (units, agents) are equipped with two kinds of operations on information granules: operations transforming tuples of information granules definable by a given agent into information granules definable by this agent and approximation operations for computing by agents approximations of information granules delivered by other agents. More complex granules are constructed by means of these operations and approximation operations from some input information granules. The construction of information granules is described by expressions called terms. We discuss a problem of synthesis of robust terms, i.e., descriptions of information granules, satisfying a given specification. This is an important problem for granular computing and its applications for spatial reasoning or knowledge discovery and data mining. © 2001 John Wiley & Sons, Inc.

221 citations

Journal ArticleDOI
TL;DR: It is shown that the linear electrical circuits composed of resistors, supercondensators, coils, and voltage (current) sources are positive systems with different fractional orders.
Abstract: A new class of positive linear systems consisting of n subsystems with different fractional orders is introduced. Solution to the set of matrix linear differential equations with different fractional orders is derived. Necessary and sufficient conditions for the positivity of the fractional systems are established. It is shown that the linear electrical circuits composed of resistors, supercondensators, coils, and voltage (current) sources are positive systems with different fractional orders.

214 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202312
202238
2021320
2020397
2019418
2018544