Institution
Bielefeld University
Education•Bielefeld, Nordrhein-Westfalen, Germany•
About: Bielefeld University is a education organization based out in Bielefeld, Nordrhein-Westfalen, Germany. It is known for research contribution in the topics: Population & Quantum chromodynamics. The organization has 10123 authors who have published 26576 publications receiving 728250 citations. The organization is also known as: University of Bielefeld & UNIVERSITAET BIELEFELD.
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Papers
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TL;DR: al. as discussed by the authors introduced the R package rptR for the estimation of ICC and R for Gaussian, binomial and Poisson-distributed data, which allows the quantification of coefficients of determination R2 as well as of raw variance components.
Abstract: Summary
Intra-class correlations (ICC) and repeatabilities (R) are fundamental statistics for quantifying the reproducibility of measurements and for understanding the structure of biological variation. Linear mixed effects models offer a versatile framework for estimating ICC and R. However, while point estimation and significance testing by likelihood ratio tests is straightforward, the quantification of uncertainty is not as easily achieved.
A further complication arises when the analysis is conducted on data with non-Gaussian distributions because the separation of the mean and the variance is less clear-cut for non-Gaussian than for Gaussian models. Nonetheless, there are solutions to approximate repeatability for the most widely used families of generalized linear mixed models (GLMMs).
Here, we introduce the R package rptR for the estimation of ICC and R for Gaussian, binomial and Poisson-distributed data. Uncertainty in estimators is quantified by parametric bootstrapping and significance testing is implemented by likelihood ratio tests and through permutation of residuals. The package allows control for fixed effects and thus the estimation of adjusted repeatabilities (that remove fixed effect variance from the estimate) and enhanced agreement repeatabilities (that add fixed effect variance to the denominator). Furthermore, repeatability can be estimated from random-slope models. The package features convenient summary and plotting functions.
Besides repeatabilities, the package also allows the quantification of coefficients of determination R2 as well as of raw variance components. We present an example analysis to demonstrate the core features and discuss some of the limitations of rptR.
1,044 citations
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TL;DR: An account of the recent explosion of actinobacterial genomics data is provided and an attempt to place this in a biological and evolutionary context.
Abstract: Summary: Actinobacteria constitute one of the largest phyla among Bacteria and represent gram-positive bacteria with a high G+C content in their DNA. This bacterial group includes microorganisms exhibiting a wide spectrum of morphologies, from coccoid to fragmenting hyphal forms, as well as possessing highly variable physiological and metabolic properties. Furthermore, Actinobacteria members have adopted different lifestyles, and can be pathogens (e.g., Corynebacterium, Mycobacterium, Nocardia, Tropheryma, and Propionibacterium), soil inhabitants (Streptomyces), plant commensals (Leifsonia), or gastrointestinal commensals (Bifidobacterium). The divergence of Actinobacteria from other bacteria is ancient, making it impossible to identify the phylogenetically closest bacterial group to Actinobacteria. Genome sequence analysis has revolutionized every aspect of bacterial biology by enhancing the understanding of the genetics, physiology, and evolutionary development of bacteria. Various actinobacterial genomes have been sequenced, revealing a wide genomic heterogeneity probably as a reflection of their biodiversity. This review provides an account of the recent explosion of actinobacterial genomics data and an attempt to place this in a biological and evolutionary context.
1,026 citations
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Brookhaven National Laboratory1, Los Alamos National Laboratory2, Lawrence Livermore National Laboratory3, University of Utah4, Indiana University5, American Physical Society6, Bielefeld University7, Goethe University Frankfurt8, University of Regensburg9, University of California, Santa Barbara10, University of Arizona11, ETH Zurich12
TL;DR: In this article, the chiral and deconfinement properties of the QCD transition at finite temperature were investigated using the p4, asqtad, and HISQ/tree actions.
Abstract: We present results on the chiral and deconfinement properties of the QCD transition at finite temperature. Calculations are performed with $2+1$ flavors of quarks using the p4, asqtad, and HISQ/tree actions. Lattices with temporal extent ${N}_{\ensuremath{\tau}}=6$, 8, and 12 are used to understand and control discretization errors and to reliably extrapolate estimates obtained at finite lattice spacings to the continuum limit. The chiral transition temperature is defined in terms of the phase transition in a theory with two massless flavors and analyzed using $O(N)$ scaling fits to the chiral condensate and susceptibility. We find consistent estimates from the HISQ/tree and asqtad actions and our main result is ${T}_{c}=154\ifmmode\pm\else\textpm\fi{}9\text{ }\text{ }\mathrm{MeV}$.
1,005 citations
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TL;DR: These analyses confirm the taxonomic position of C. glutamicum as related to Mycobacteria and show a broad metabolic diversity as expected for a bacterium living in the soil.
948 citations
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TL;DR: Analysis of plants expressing targeted modifications of components of the antioxidant system and comparison of closely related plant species with different degrees of toxic metal sensitivity have established a link between the degree of plant tolerance to metals and the level of antioxidants.
947 citations
Authors
Showing all 10375 results
Name | H-index | Papers | Citations |
---|---|---|---|
Stefan Grimme | 113 | 680 | 105087 |
Alfred Pühler | 102 | 658 | 45871 |
James Barber | 102 | 642 | 42397 |
Swagata Mukherjee | 101 | 1048 | 46234 |
Hans-Joachim Werner | 98 | 317 | 48508 |
Krzysztof Redlich | 98 | 609 | 32693 |
Graham C. Walker | 93 | 381 | 36875 |
Christian Meyer | 93 | 1081 | 38149 |
Muhammad Farooq | 92 | 1341 | 37533 |
Jean Willy Andre Cleymans | 90 | 542 | 27685 |
Bernhard T. Baune | 90 | 608 | 50706 |
Martin Wikelski | 89 | 420 | 25821 |
Niklas Luhmann | 85 | 421 | 42743 |
Achim Müller | 85 | 926 | 35874 |
Oliver T. Wolf | 83 | 337 | 24211 |